medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2018-1-33-37medsovet-2265Research ArticleГОЛОВНАЯ БОЛЬ И ГОЛОВОКРУЖЕНИЕHEADACHE AND VERTIGOРоль мелатонина в терапии хронической головной болиTHE ROLE OF MELATONIN IN THE TREATMENT OF CHRONIC HEADACHE КургановаЮ. М.KurganovaYu. M.ДаниловА. Б.DanilovA. B.

д.м.н., профессор

MD, Prof.

Первый Московский государственный медицинский университет им. И.М. СеченоваРоссияSechenov First Moscow State Medical UniversityRussian Federation201805022018013337Copyright © Курганова Ю.М., Данилов А.Б., 20182018Курганова Ю.М., Данилов А.Б.Kurganova Y.M., Danilov A.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/2265

Мелатонин – эндогенный хронобиотик, продемонстрировавший в ряде экспериментальных и клинических работ свои анальгетические возможности. Он оказался эффективен при фибромиалгии, синдроме раздраженного кишечника, боли в спине и различных типах головной боли. Наиболее высокий уровень доказательности анальгетических свойств мелатонина при мигрени и кластерной головной боли. В данном обзоре рассмотрены основные работы, имеющиеся на данный момент, где мелатонин используется при первичных головных болях различного типа. Обсуждаются возможные механизмы реализации мелатонином анальгетического действия и перспективы его использования в комплексной терапии головной боли.

 

Melatonin is an endogenous chronobiotic that demonstrated its analgesic potential in an array of experimental and clinical studies. It proved efficient in fibromyalgia, irritable bowel syndrome, back pain and various types of headache. The level of evidence supporting melatonin’s analgesic properties in treating migraine and cluster headache is the highest. This review provides a summary of main papers currently available about the use of melatonin in the treatment of primary headache disorders of various types. It discusses possible mechanisms of melatonin analgesic action and prospects of its use in combination therapy of headache.

 

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The authors declare that there are no conflicts of interest present.