<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2018-2-42-51</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-2286</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЗДОРОВЫЙ РЕБЕНОК</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>HEALTHY CHILD</subject></subj-group></article-categories><title-group><article-title>Уход за кожей детей раннего возраста. Новые инновационные подходы</article-title><trans-title-group xml:lang="en"><trans-title>SKIN CARE IN YOUNG CHILDREN: INNOVATIVE APPROACHES</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Захарова</surname><given-names>И. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Zakharova</surname><given-names>I. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор медицинских наук, профессор.</p><p>Москва</p></bio><bio xml:lang="en"><p>MD, Prof.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Касьянова</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Kasyanova</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мачнева</surname><given-names>Е. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Machneva</surname><given-names>E. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кандидат медицинских наук</p><p>Москва</p></bio><bio xml:lang="en"><p>PhD in medicine.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российская медицинская академия непрерывного профессионального образования</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Medical Academy of Continuing Vocational Education of the Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>13</day><month>02</month><year>2018</year></pub-date><volume>0</volume><issue>2</issue><fpage>42</fpage><lpage>51</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Захарова И.Н., Касьянова А.Н., Мачнева Е.Б., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Захарова И.Н., Касьянова А.Н., Мачнева Е.Б.</copyright-holder><copyright-holder xml:lang="en">Zakharova I.N., Kasyanova A.N., Machneva E.B.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/2286">https://www.med-sovet.pro/jour/article/view/2286</self-uri><abstract><p>В статье представлены современные данные об онтогенезе кожи, о формировании всех ее элементов и структур во время внутриутробного развития и в постнатальный период. Подробно освещены современные представления об особенностях строения кожи у новорожденного и младенца. Особое внимание уделено как защитным механизмам кожи, обеспечивающим механический барьер, так и факторам врожденного иммунитета, липидам, а также микробиому кожи. Большое внимание в представленной статье уделено значению сыровидной смазки для кожи плода и новорожденного, а также процессам адаптации кожи новорожденного к внеутробной среде. Представлены современные рекомендации по уходу за кожей, основанные на данных об особенностях развития, строения и функционирования кожи новорожденного и младенца.</p></abstract><trans-abstract xml:lang="en"><p>The article presents modern data on the ontogenesis of the skin, the formation of all its elements and structures during prenatal development and postnatal period. The modern ideas about the features of the structure of the skin in the newborn and infant are highlighted in detail. Particular attention is paid to the protective mechanisms of the skin, providing a mechanical barrier, and factors of innate immunity, lipids, as well as skin microbiome. Much attention is paid to the importance of the dampening for the skin of the fetus and newborn, as well as the processes of adaptation of the skin of the newborn to the extrauterine environment. The modern recommendations for skin care, based on data of the features of the development, structure and functioning of the skin of the newborn and infant are presented.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>адаптация</kwd><kwd>дерма</kwd><kwd>дети</kwd><kwd>кожа</kwd><kwd>микробиота кожи</kwd><kwd>новорожденные</kwd><kwd>сыровидная смазка</kwd><kwd>уход</kwd><kwd>эпидермис</kwd><kwd>эмбриогенез</kwd></kwd-group><kwd-group xml:lang="en"><kwd>adaptation</kwd><kwd>dermis</kwd><kwd>children</kwd><kwd>leather</kwd><kwd>skin microbiota</kwd><kwd>newborns</kwd><kwd>skin</kwd><kwd>epidermis</kwd><kwd>embryogenesis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Захарова И.Н., Пшеничникова И.И., Мачнева Е.Б. Правильный уход за кожей новорожденных и детей раннего возраста: что нужно знать педиатру. Педиатрия. Приложение к журналу Consilium Medicum, 2016, 1: 24-30.</mixed-citation><mixed-citation xml:lang="en">Захарова И.Н., Пшеничникова И.И., Мачнева Е.Б. Правильный уход за кожей новорожденных и детей раннего возраста: что нужно знать педиатру. Педиатрия. Приложение к журналу Consilium Medicum, 2016, 1: 24-30.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Visscher MO, Adam R, Brink S, Odio M. Newborn infant skin: physiology, development, and care. Clin Dermatol, 2015, 33: 271–280.</mixed-citation><mixed-citation xml:lang="en">Visscher MO, Adam R, Brink S, Odio M. Newborn infant skin: physiology, development, and care. Clin Dermatol, 2015, 33: 271–280.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Kutlubay Z, Tanakol A, Engýn B, Onel C, Sýmsek E, Serdaroglu S, Tuzun Y, Yilmaz E, Eren B. Newborn Skin: Common Skin Problems. Maedica (Buchar), 2017, 12(1): 42-47.</mixed-citation><mixed-citation xml:lang="en">Kutlubay Z, Tanakol A, Engýn B, Onel C, Sýmsek E, Serdaroglu S, Tuzun Y, Yilmaz E, Eren B. Newborn Skin: Common Skin Problems. Maedica (Buchar), 2017, 12(1): 42-47.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Visscher M, Narendran V. The Ontogeny of Skin. Adv Wound Care (New Rochelle), 2014, 3(4): 291-303.</mixed-citation><mixed-citation xml:lang="en">Visscher M, Narendran V. The Ontogeny of Skin. Adv Wound Care (New Rochelle), 2014, 3(4): 291-303.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Fuchs E. Scratching the surface of skin development. Nature, 2007, 445: 834-842.</mixed-citation><mixed-citation xml:lang="en">Fuchs E. Scratching the surface of skin development. Nature, 2007, 445: 834-842.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Blanpain C, Fuchs E. Epidermal homeostasis: a balancing act of stem cells in the skin. Nat Rev Mol Cell Biol, 2009, 10: 207-217.</mixed-citation><mixed-citation xml:lang="en">Blanpain C, Fuchs E. Epidermal homeostasis: a balancing act of stem cells in the skin. Nat Rev Mol Cell Biol, 2009, 10: 207-217.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Blume-Peytavi U, Hauser M, Stamatas GN. Skin care practices for newborns and infants: Review of the clinical evidence for best practices. Pediatr Dermatol, 2012, 29: 1-14.</mixed-citation><mixed-citation xml:lang="en">Blume-Peytavi U, Hauser M, Stamatas GN. Skin care practices for newborns and infants: Review of the clinical evidence for best practices. Pediatr Dermatol, 2012, 29: 1-14.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Candi E, Schmidt R, Melino G. The cornified envelope: a model of cell death in the skin. Nat Rev Mol Cell Biol, 2005, 6: 328-340.</mixed-citation><mixed-citation xml:lang="en">Candi E, Schmidt R, Melino G. The cornified envelope: a model of cell death in the skin. Nat Rev Mol Cell Biol, 2005, 6: 328-340.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Уход за кожей новорожденного ребенка. Союз педиатров России. 2016: 66 с.</mixed-citation><mixed-citation xml:lang="en">Уход за кожей новорожденного ребенка. Союз педиатров России. 2016: 66 с.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Kalinin A, Marekov LN, Steinert PM. Assembly of the epidermal cornified cell envelope. J Cell Sci, 2001, 114: 3069-3070.</mixed-citation><mixed-citation xml:lang="en">Kalinin A, Marekov LN, Steinert PM. Assembly of the epidermal cornified cell envelope. J Cell Sci, 2001, 114: 3069-3070.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Pickens WL, Warner RR, Boissy YL, Boissy RE, Hoath SB. Characterization of vernix caseosa: water content, morphology, and elemental analysis. J Invest Dermatol, 2000, 115: 875-881.</mixed-citation><mixed-citation xml:lang="en">Pickens WL, Warner RR, Boissy YL, Boissy RE, Hoath SB. Characterization of vernix caseosa: water content, morphology, and elemental analysis. J Invest Dermatol, 2000, 115: 875-881.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Visscher MO, Narendran V, Pickens WL, LaRuffa AA, Meinzen-Derr J, Allen K, Hoath SB. Vernix caseosa in neonatal adaptation. J Perinatol, 2005, 25: 440-446.</mixed-citation><mixed-citation xml:lang="en">Visscher MO, Narendran V, Pickens WL, LaRuffa AA, Meinzen-Derr J, Allen K, Hoath SB. Vernix caseosa in neonatal adaptation. J Perinatol, 2005, 25: 440-446.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Rissmann R, Groenink HW, Weerheim AM, Hoath SB, Ponec M, Bouwstra JA. New insights into ultrastructure, lipid composition and organization of vernix caseosa. J Invest Dermatol, 2006, 126: 1823-1833.</mixed-citation><mixed-citation xml:lang="en">Rissmann R, Groenink HW, Weerheim AM, Hoath SB, Ponec M, Bouwstra JA. New insights into ultrastructure, lipid composition and organization of vernix caseosa. J Invest Dermatol, 2006, 126: 1823-1833.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Youssef W, Wickett RR, Hoath SB. Surface free energy characterization of vernix caseosa. Potential role in waterproofing the newborn infant. Skin Res Technol, 2001, 7: 10-17.</mixed-citation><mixed-citation xml:lang="en">Youssef W, Wickett RR, Hoath SB. Surface free energy characterization of vernix caseosa. Potential role in waterproofing the newborn infant. Skin Res Technol, 2001, 7: 10-17.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Barai N. Effect of vernix caseosa on epidermal barrier maturation and repair: Implications inwound healing. [PhDthesis]Cincinnati,OHUSA: University of Cincinnati, Pharmacy. 2005. http: //rave.ohiolink.edu/etdc/view?acc_num=ucin1115914411. Accessed March 13, 2014.</mixed-citation><mixed-citation xml:lang="en">Barai N. Effect of vernix caseosa on epidermal barrier maturation and repair: Implications inwound healing. [PhDthesis]Cincinnati,OHUSA: University of Cincinnati, Pharmacy. 2005. http: //rave.ohiolink.edu/etdc/view?acc_num=ucin1115914411. Accessed March 13, 2014.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Oudshoorn MHM, Rissmann R, van der Coelen D. Development of a murine model to evaluate the effect of vernix caseosa on skin barrier recovery. Exp Dermatol, 2009, 18: 178-184.</mixed-citation><mixed-citation xml:lang="en">Oudshoorn MHM, Rissmann R, van der Coelen D. Development of a murine model to evaluate the effect of vernix caseosa on skin barrier recovery. Exp Dermatol, 2009, 18: 178-184.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Visscher MO, Barai N, LaRuffa AA. Epidermal barrier treatments based on vernix caseosa. Skin Pharmacol Physiol, 2011, 24: 322-329.</mixed-citation><mixed-citation xml:lang="en">Visscher MO, Barai N, LaRuffa AA. Epidermal barrier treatments based on vernix caseosa. Skin Pharmacol Physiol, 2011, 24: 322-329.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Narendran V, Visscher MO, Abril I. Biomarkers of epidermal innate immunity in premature and full-term infants. Pediatr Res, 2010, 67: 382-386.</mixed-citation><mixed-citation xml:lang="en">Narendran V, Visscher MO, Abril I. Biomarkers of epidermal innate immunity in premature and full-term infants. Pediatr Res, 2010, 67: 382-386.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Tollin M, Bergsson G, Kai-Larsen Y. Vernix caseosa as a multicomponent defence system based on polypeptides, lipids and their interactions. Cell Mol Life Sci, 2005, 62: 2390-2399.</mixed-citation><mixed-citation xml:lang="en">Tollin M, Bergsson G, Kai-Larsen Y. Vernix caseosa as a multicomponent defence system based on polypeptides, lipids and their interactions. Cell Mol Life Sci, 2005, 62: 2390-2399.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Visscher MO, Narendran V, Pickens WL. Vernix caseosa in neonatal adaptation. J Perinatol, 2005, 25: 440-446.</mixed-citation><mixed-citation xml:lang="en">Visscher MO, Narendran V, Pickens WL. Vernix caseosa in neonatal adaptation. J Perinatol, 2005, 25: 440-446.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Нагаева Т.А., Басарева Н.И., Пономарева Д.А. Особенности липидного состава поверхностной гидролипидной пленки кожи новорожденных детей. В сборнике: Актуальные направления фундаментальных и прикладных исследований. Материалы IX международной научно-практической конференции. Н.-и. ц. «Академический». 2016: 28-31.</mixed-citation><mixed-citation xml:lang="en">Нагаева Т.А., Басарева Н.И., Пономарева Д.А. Особенности липидного состава поверхностной гидролипидной пленки кожи новорожденных детей. В сборнике: Актуальные направления фундаментальных и прикладных исследований. Материалы IX международной научно-практической конференции. Н.-и. ц. «Академический». 2016: 28-31.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Tansirikongkol A, Wickett RR, Visscher MO. Effect of vernix caseosa on the penetration of chymotryptic enzyme: Potential role inиepidermal barrier development. Pediatr Res, 2007, 62: 49-53.</mixed-citation><mixed-citation xml:lang="en">Tansirikongkol A, Wickett RR, Visscher MO. Effect of vernix caseosa on the penetration of chymotryptic enzyme: Potential role inиepidermal barrier development. Pediatr Res, 2007, 62: 49-53.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Newborn care until the first week of life: Clinical practice pocket guide. World Health Organization. http: //www.wpro.who.int/immunization/documents/newborncare_final.pdf. [Published 2009. Accessed March 13, 2014].</mixed-citation><mixed-citation xml:lang="en">Newborn care until the first week of life: Clinical practice pocket guide. World Health Organization. http: //www.wpro.who.int/immunization/documents/newborncare_final.pdf. [Published 2009. Accessed March 13, 2014].</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Stamatas GN, Nikolovski J, Mack MC. Infant skin physiology and development during the first years of life: A review of recent findings based on in vivo studies. Int J Cosmet Sci, 2011, 33: 17-24.</mixed-citation><mixed-citation xml:lang="en">Stamatas GN, Nikolovski J, Mack MC. Infant skin physiology and development during the first years of life: A review of recent findings based on in vivo studies. Int J Cosmet Sci, 2011, 33: 17-24.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Darlenski R, Fluhr JW. Influence of skin type, race, sex, and anatomic location on epidermal barrier function. Clin Dermatol, 2012, 30: 269-273.</mixed-citation><mixed-citation xml:lang="en">Darlenski R, Fluhr JW. Influence of skin type, race, sex, and anatomic location on epidermal barrier function. Clin Dermatol, 2012, 30: 269-273.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Hoeger PH. Physiology of neonatal skin. In: Irvine AD, Hoeger PH, Yan AC, eds. Harper’s textbook of pediatric dermatology. Oxford, UK: Wiley-Blackwell, 2011. p. 3.1-3.7.</mixed-citation><mixed-citation xml:lang="en">Hoeger PH. Physiology of neonatal skin. In: Irvine AD, Hoeger PH, Yan AC, eds. Harper’s textbook of pediatric dermatology. Oxford, UK: Wiley-Blackwell, 2011. p. 3.1-3.7.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Kelleher MM, O’Carroll M, Gallagher A. Newborn transepidermal water loss values: A reference data set. Pediatr Dermatol, 2013, 30: 712-716.</mixed-citation><mixed-citation xml:lang="en">Kelleher MM, O’Carroll M, Gallagher A. Newborn transepidermal water loss values: A reference data set. Pediatr Dermatol, 2013, 30: 712-716.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Fluhr JW, Darlenski R, Lachmann N. Infant epidermal skin physiology: Adaptation after birth. Br J Dermatol, 2012, 166: 483-490.</mixed-citation><mixed-citation xml:lang="en">Fluhr JW, Darlenski R, Lachmann N. Infant epidermal skin physiology: Adaptation after birth. Br J Dermatol, 2012, 166: 483-490.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Sedin G, Hammarlund K, Stromberg B. Transepidermal water loss in full-term and pretermb infants. Acta Paediatr Scand Suppl, 1983, 305: 27-31.</mixed-citation><mixed-citation xml:lang="en">Sedin G, Hammarlund K, Stromberg B. Transepidermal water loss in full-term and pretermb infants. Acta Paediatr Scand Suppl, 1983, 305: 27-31.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Agren J, Sjors G, Sedin G. Ambient humidity influences the rate of skin barrier maturation in extremely preterm infants. J Pediatr, 2006, 148: 613-617.</mixed-citation><mixed-citation xml:lang="en">Agren J, Sjors G, Sedin G. Ambient humidity influences the rate of skin barrier maturation in extremely preterm infants. J Pediatr, 2006, 148: 613-617.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Захарова И.Н., Мачнева Е.Б. Уход за кожей детей раннего возраста. Вопросы современной педиатрии, 2014, 13(2): 95-100.</mixed-citation><mixed-citation xml:lang="en">Захарова И.Н., Мачнева Е.Б. Уход за кожей детей раннего возраста. Вопросы современной педиатрии, 2014, 13(2): 95-100.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Fluhr JW, Darlenski R, Taieb A. Functional skin adaptation in infancy-almost complete but not fully competent. Exp Dermatol, 2010, 19: 483-492.</mixed-citation><mixed-citation xml:lang="en">Fluhr JW, Darlenski R, Taieb A. Functional skin adaptation in infancy-almost complete but not fully competent. Exp Dermatol, 2010, 19: 483-492.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Nikolovski J, Stamatas GN, Kollias N. Barrier function and water-holding and transport properties of infant stratum corneum are different from adult and continue to develop through the first year of life. J Invest Dermatol, 2008, 128: 1728-1736.</mixed-citation><mixed-citation xml:lang="en">Nikolovski J, Stamatas GN, Kollias N. Barrier function and water-holding and transport properties of infant stratum corneum are different from adult and continue to develop through the first year of life. J Invest Dermatol, 2008, 128: 1728-1736.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Minami-Hori M, Honma M, Fujii M, et al. Developmental alterations of physical properties and components of neonatal-infantile stratum corneum of upper thighs and diaper-covered buttocks during the 1st year of life. J Dermatol Sci, 2014, 73: 67-73.</mixed-citation><mixed-citation xml:lang="en">Minami-Hori M, Honma M, Fujii M, et al. Developmental alterations of physical properties and components of neonatal-infantile stratum corneum of upper thighs and diaper-covered buttocks during the 1st year of life. J Dermatol Sci, 2014, 73: 67-73.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Visscher MO, Chatterjee R, Munson KA. Changes in diapered and nondiapered infant skin over the first month of life. Pediatr Dermatol, 2000, 17: 45-51.</mixed-citation><mixed-citation xml:lang="en">Visscher MO, Chatterjee R, Munson KA. Changes in diapered and nondiapered infant skin over the first month of life. Pediatr Dermatol, 2000, 17: 45-51.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Нагаева Т.А., Басарева Н.И., Пономарева Д.А. Особенности витаминного состава поверхностной гидролипидной пленки кожи у здоровых новорожденных и грудных детей. Международный журнал экспериментального образования, 2016, 9(1): 75-76.</mixed-citation><mixed-citation xml:lang="en">Нагаева Т.А., Басарева Н.И., Пономарева Д.А. Особенности витаминного состава поверхностной гидролипидной пленки кожи у здоровых новорожденных и грудных детей. Международный журнал экспериментального образования, 2016, 9(1): 75-76.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Narendran V, Visscher MO, Abril I, Hendrix SW, Hoath SB. Biomarkers of epidermal innate immunity in premature and full-term infants. Pediatr Res, 2010, 67: 382-386.</mixed-citation><mixed-citation xml:lang="en">Narendran V, Visscher MO, Abril I, Hendrix SW, Hoath SB. Biomarkers of epidermal innate immunity in premature and full-term infants. Pediatr Res, 2010, 67: 382-386.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Hirao T, Terui T, Takeuchi I, Kobayashi H, Okada M, Takahashi M, Tagami H. Ratio of immature cornified envelopes does not correlate with parakeratosis in inflammatory skin disorders. Exp Dermatol, 2003, 12: 591-601.</mixed-citation><mixed-citation xml:lang="en">Hirao T, Terui T, Takeuchi I, Kobayashi H, Okada M, Takahashi M, Tagami H. Ratio of immature cornified envelopes does not correlate with parakeratosis in inflammatory skin disorders. Exp Dermatol, 2003, 12: 591-601.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Yamane Y, Moriyama K, Yasuda C, Miyata S, Aihara M, Ikezawa Z, Miyazaki K. New horny layer marker proteins for evaluating skin condition in atopic dermatitis. Int Arch Allergy Immunol, 2009, 150: 89-101.</mixed-citation><mixed-citation xml:lang="en">Yamane Y, Moriyama K, Yasuda C, Miyata S, Aihara M, Ikezawa Z, Miyazaki K. New horny layer marker proteins for evaluating skin condition in atopic dermatitis. Int Arch Allergy Immunol, 2009, 150: 89-101.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Jiang YJ, Lu B, Crumrine D, Man MQ, Elias PM, Feingold KR. IL-1alpha accelerates stratum corneum formation and improves permeability barrier homeostasis during murine fetal development. J Dermatol Sci, 2009, 54: 88-98.</mixed-citation><mixed-citation xml:lang="en">Jiang YJ, Lu B, Crumrine D, Man MQ, Elias PM, Feingold KR. IL-1alpha accelerates stratum corneum formation and improves permeability barrier homeostasis during murine fetal development. J Dermatol Sci, 2009, 54: 88-98.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Захарова И.Н., Климов Л.Я., Касьянова А.Н., Ягупова А.В., Курьянинова В.А. Долбня С.В., Батурин В.А., Бобрышев Д.В., Анисимов Г.С., Масальский С.С., Болатчиев А.Д. Роль антимикробных пептидов и витамина D в формировании противоинфекционной защиты. Педиатрия, Журнал им. Г.Н. Сперанского, 2017, 96(4): 171–179.</mixed-citation><mixed-citation xml:lang="en">Захарова И.Н., Климов Л.Я., Касьянова А.Н., Ягупова А.В., Курьянинова В.А. Долбня С.В., Батурин В.А., Бобрышев Д.В., Анисимов Г.С., Масальский С.С., Болатчиев А.Д. Роль антимикробных пептидов и витамина D в формировании противоинфекционной защиты. Педиатрия, Журнал им. Г.Н. Сперанского, 2017, 96(4): 171–179.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Agier J, Brzezinska-Blaszczyk E. Cathelicidins and defensins regulate mast cell antimicrobial activity. Postepy Hig Med Dosw (Online), 2016, 70(0): 618-636.</mixed-citation><mixed-citation xml:lang="en">Agier J, Brzezinska-Blaszczyk E. Cathelicidins and defensins regulate mast cell antimicrobial activity. Postepy Hig Med Dosw (Online), 2016, 70(0): 618-636.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Walker VP, Akinbi HT, Meinzen-Derr J, Narendran V, Visscher M, Hoath SB. Host defense proteins on the surface of neonatal skin: implications for innate immunity. J Pediatr, 2008, 152: 777-781.</mixed-citation><mixed-citation xml:lang="en">Walker VP, Akinbi HT, Meinzen-Derr J, Narendran V, Visscher M, Hoath SB. Host defense proteins on the surface of neonatal skin: implications for innate immunity. J Pediatr, 2008, 152: 777-781.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Pammi M, O’Brien JL, Ajami NJ, Wong MC, Versalovic J, Petrosino JF. Development of the cutaneous microbiome in the preterm infant: A prospective longitudinalstudy. PLoS One, 2017, 12(4): e0176669.</mixed-citation><mixed-citation xml:lang="en">Pammi M, O’Brien JL, Ajami NJ, Wong MC, Versalovic J, Petrosino JF. Development of the cutaneous microbiome in the preterm infant: A prospective longitudinalstudy. PLoS One, 2017, 12(4): e0176669.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Grice EA, Segre JA. The skin microbiome. Nat Rev Microbiol, 2011, 9: 244-253.</mixed-citation><mixed-citation xml:lang="en">Grice EA, Segre JA. The skin microbiome. Nat Rev Microbiol, 2011, 9: 244-253.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Hoeger PH, Enzmann CC. Skin physiology of the neonate and young infant: a prospective study of functional skin parameters during early infancy. Pediatr Dermatol, 2002, 19: 256-262.</mixed-citation><mixed-citation xml:lang="en">Hoeger PH, Enzmann CC. Skin physiology of the neonate and young infant: a prospective study of functional skin parameters during early infancy. Pediatr Dermatol, 2002, 19: 256-262.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Hachem J, Roelandt T, Schürer N. Acute acidification of stratum corneum membrane domains using polyhydroxyl acids improves lipid processing and inhibits degradation of corneodesmosomes. J Invest Dermatol, 2010, 130: 500-510.</mixed-citation><mixed-citation xml:lang="en">Hachem J, Roelandt T, Schürer N. Acute acidification of stratum corneum membrane domains using polyhydroxyl acids improves lipid processing and inhibits degradation of corneodesmosomes. J Invest Dermatol, 2010, 130: 500-510.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Eggesbo M, Moen B, Peddada S, Baird D. Development of gut microbiota in infants not exposed to medical interventions. APMIS, 2011, 119(1): 17-35.</mixed-citation><mixed-citation xml:lang="en">Eggesbo M, Moen B, Peddada S, Baird D. Development of gut microbiota in infants not exposed to medical interventions. APMIS, 2011, 119(1): 17-35.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Stoll BJ, Hansen N, Fanaroff AA, Wright LL, Carlo WA. Ehrenkranz RA Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics, 2002, 110: 285-291.</mixed-citation><mixed-citation xml:lang="en">Stoll BJ, Hansen N, Fanaroff AA, Wright LL, Carlo WA. Ehrenkranz RA Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics, 2002, 110: 285-291.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Naik S, Bouladoux N, Wilhelm C, Molloy MJ, Salcedo R, Kastenmuller W. Compartmentalized control of skin immunity by resident commensals. Science, 2012, 337: 1115-1119.</mixed-citation><mixed-citation xml:lang="en">Naik S, Bouladoux N, Wilhelm C, Molloy MJ, Salcedo R, Kastenmuller W. Compartmentalized control of skin immunity by resident commensals. Science, 2012, 337: 1115-1119.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Grice EA, Kong HH, Conlan S, Deming CB, Davis J, Young AC. Topographical and temporal diversity of the human skin microbiome. Science, 2009, 324: 1190-1192.</mixed-citation><mixed-citation xml:lang="en">Grice EA, Kong HH, Conlan S, Deming CB, Davis J, Young AC. Topographical and temporal diversity of the human skin microbiome. Science, 2009, 324: 1190-1192.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Gao Z, Tseng CH, Pei Z, Blaser MJ. Molecular analysis of human forearm superficial skin bacterial biota. Proc Natl Acad Sci U S A, 2007, 104: 2927-2932.</mixed-citation><mixed-citation xml:lang="en">Gao Z, Tseng CH, Pei Z, Blaser MJ. Molecular analysis of human forearm superficial skin bacterial biota. Proc Natl Acad Sci U S A, 2007, 104: 2927-2932.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Capone KA, Dowd SE, Stamatas GN, Nikolovski J. Diversity of the human skin microbiome early in life. J Invest Dermatol, 2011, 131(10): 2026-32.</mixed-citation><mixed-citation xml:lang="en">Capone KA, Dowd SE, Stamatas GN, Nikolovski J. Diversity of the human skin microbiome early in life. J Invest Dermatol, 2011, 131(10): 2026-32.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Dominguez-Bello MG, Costello EK, Contreras M. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci USA, 2010, 107: 11971–11975.</mixed-citation><mixed-citation xml:lang="en">Dominguez-Bello MG, Costello EK, Contreras M. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci USA, 2010, 107: 11971–11975.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Blume-Peytavi U, Lavender T, Jenerowicz D, Ryumina I, Stalder JF, Torrelo A, Cork MJ. Recommendations from a European Roundtabl e Meeting on Best Practice Healthy Infant Skin Care. Pediatr Dermatol, 2016, b33(3): 311-221.</mixed-citation><mixed-citation xml:lang="en">Blume-Peytavi U, Lavender T, Jenerowicz D, Ryumina I, Stalder JF, Torrelo A, Cork MJ. Recommendations from a European Roundtabl e Meeting on Best Practice Healthy Infant Skin Care. Pediatr Dermatol, 2016, b33(3): 311-221.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Telofski LS, Morello AP, Mack Correa MC, Stamatas GN. The infant skin barrier: Can we preserve, protect, and enhance the barrier? Dermatol Res Pract, 2012, 2012: 198789.</mixed-citation><mixed-citation xml:lang="en">Telofski LS, Morello AP, Mack Correa MC, Stamatas GN. The infant skin barrier: Can we preserve, protect, and enhance the barrier? Dermatol Res Pract, 2012, 2012: 198789.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Ananthapadmanabhan KP, Moore DJ, Subramanyan K. Cleansing without compromise: the impact of cleansers on the skin barrier and the technology of mild cleansing. Dermatol Ther, 2004, 17(Suppl 1): 16–25.</mixed-citation><mixed-citation xml:lang="en">Ananthapadmanabhan KP, Moore DJ, Subramanyan K. Cleansing without compromise: the impact of cleansers on the skin barrier and the technology of mild cleansing. Dermatol Ther, 2004, 17(Suppl 1): 16–25.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Garcia Bartels N, Massoudy L, Scheufele R. Standardized diaper care regimen: A prospective, randomized pilot study on skin barrier function and epidermal IL-1α in newborns. Pediatr Dermatol, 2012, 29: 270-276.</mixed-citation><mixed-citation xml:lang="en">Garcia Bartels N, Massoudy L, Scheufele R. Standardized diaper care regimen: A prospective, randomized pilot study on skin barrier function and epidermal IL-1α in newborns. Pediatr Dermatol, 2012, 29: 270-276.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Тамразова О.Б. Особенности ухода за кожей новорожденных детей. Педиатрия. Приложение к журналу Consilium Medicum, 2014, 1: 77-82.</mixed-citation><mixed-citation xml:lang="en">Тамразова О.Б. Особенности ухода за кожей новорожденных детей. Педиатрия. Приложение к журналу Consilium Medicum, 2014, 1: 77-82.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Erasala G, Merlay I, Romain C. Evolution of disposable diapers and reduction of diaper dermatitis. Arch Pediatr, 2007, 14: 495-500.</mixed-citation><mixed-citation xml:lang="en">Erasala G, Merlay I, Romain C. Evolution of disposable diapers and reduction of diaper dermatitis. Arch Pediatr, 2007, 14: 495-500.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Котлуков В.К., Казюкова Т.В., Антипова Н.В. Наружные дерматологические средства для ухода за кожей детей первых лет жизни. Медицинский совет, 2017, 9: 160-161.</mixed-citation><mixed-citation xml:lang="en">Котлуков В.К., Казюкова Т.В., Антипова Н.В. Наружные дерматологические средства для ухода за кожей детей первых лет жизни. Медицинский совет, 2017, 9: 160-161.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Walker VP, Akinbi HT, Meinzen-Derr J. Host defense proteins on the surface of neonatal skin: Implications for innate immunity. J Pediatr, 2008, 152: 777-781.</mixed-citation><mixed-citation xml:lang="en">Walker VP, Akinbi HT, Meinzen-Derr J. Host defense proteins on the surface of neonatal skin: Implications for innate immunity. J Pediatr, 2008, 152: 777-781.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Schürer NY. Implementation of fatty acid carriers to skin irritation and the epidermal barrier. Contact Dermatitis, 2002, 47: 199-205.</mixed-citation><mixed-citation xml:lang="en">Schürer NY. Implementation of fatty acid carriers to skin irritation and the epidermal barrier. Contact Dermatitis, 2002, 47: 199-205.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Nopper AJ, Horii KA, Sookdeo-Drost S, et al. Topical ointment therapy benefits premature infants. J Pediatr, 1996, 128: 660-669.</mixed-citation><mixed-citation xml:lang="en">Nopper AJ, Horii KA, Sookdeo-Drost S, et al. Topical ointment therapy benefits premature infants. J Pediatr, 1996, 128: 660-669.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Kiechl-Kohlendorfer U, Berger C, Inzinger R. The effect of daily treatment with an olive oil/lanolin emollient on skin integrity in preterm infants: A randomized controlled trial. Pediatr Dermatol, 2008, 25: 174-178.</mixed-citation><mixed-citation xml:lang="en">Kiechl-Kohlendorfer U, Berger C, Inzinger R. The effect of daily treatment with an olive oil/lanolin emollient on skin integrity in preterm infants: A randomized controlled trial. Pediatr Dermatol, 2008, 25: 174-178.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
