medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2018-2-182-187medsovet-2311Research ArticleНЕФРОЛОГИЯ / УРОЛОГИЯNEPHROLOGY / UROLOGYГенетические и молекулярные основы бессимптомной бактериурии у детей: что нового?GENETIC AND MOLECULAR BASIS OF ASYMPTOMATIC BACTERIURIA IN CHILDREN: WHAT’S NEW?ЗахароваИ. Н.ZakharovaI. N.

Доктор медицинских наук, профессор.

Москва

MD, Prof.

ОсмановИ. М.OsmanovI. M.

Доктор медицинских наук, профессор

MD, Prof.

МумладзеЭ. Б.MumladzeE. B.

Кандидат медицинских наук.

PhD in medicine.

МачневаЕ. Б.MachnevaE. B.

Кандидат медицинских наук.

PhD in medicine.

СвинцицкаяВ. И.SvintsitskayaB. I.

Кандидат медицинских наук.

Москва

PhD in medicine.

КасьяноваА. Н.KasyanovaA. N.

Москва

Moscow

ОблогинаИ. С.ObloginaI. S.

Москва

Moscow

ТамбиеваЕ. В.TambievaE. V.

Кандидат медицинских наук

PhD in medicine

БекмурзаеваГ. Б.BekmurzaevaG. B.ВасильеваТ. М.VasilievaT. M.

Москва

ЛупанИ. Н.LupanI. N.

Челябинск

Российская медицинская академия непрерывного профессионального образования Минздрава РоссииРоссияRussian Medical Academy of Continuing Postgraduate Education of the Ministry of Health of RussiaRussian FederationДетская городская клиническая больница им. З.А. Башляевой Департамента здравоохранения г. МосквыРоссияBashlyaeva Children’s City Clinical Hospital З.А. of the Moscow Department of HealthcareRussian FederationЮжно-Уральский государственный медицинский университет Минздрава РоссииРоссияSouth Ural State Medical University of the Ministry of Health of RussiaRussian Federation20181402201802182187Copyright © Захарова И.Н., Османов И.М., Мумладзе Э.Б., Мачнева Е.Б., Свинцицкая В.И., Касьянова А.Н., Облогина И.С., Тамбиева Е.В., Бекмурзаева Г.Б., Васильева Т.М., Лупан И.Н., 20182018Захарова И.Н., Османов И.М., Мумладзе Э.Б., Мачнева Е.Б., Свинцицкая В.И., Касьянова А.Н., Облогина И.С., Тамбиева Е.В., Бекмурзаева Г.Б., Васильева Т.М., Лупан И.Н.Zakharova I.N., Osmanov I.M., Mumladze E.B., Machneva E.B., Svintsitskaya B.I., Kasyanova A.N., Oblogina I.S., Tambieva E.V., Bekmurzaeva G.B., Vasilieva T.M., Lupan I.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/2311

В последние годы в связи с совершенствованием генетических и молекулярных методов исследования как микроорганизмов, так и отдельных структур клеток человека возрос интерес ученых к тончайшим механизмам взаимодействия макро- и микроорганизма. Изучение микробиома и разнообразия микроорганизмов на всех участках организма человека дало толчок к новому пониманию развития многих заболеваний и, соответственно, к возможности создания новых терапевтических подходов. Не является исключением и микробиота мочевого пузыря, которая вызывает интерес многих ученых в отношении механизмов формирования бессимптомной бактериурии (ББ) и инфекции мочевых путей (ИМП). Представленная статья посвящена обзору исследований последних лет, сконцентрированных на изучении генетических, иммунных и молекулярных механизмов взаимодействия макро- и микроорганизма при развитии ИМП.

Due to improvement of genetic and molecular methods of study of both micro-organisms and individual human cell structures, the interest of scientists in the finest mechanisms of interaction between macro- and microorganisms has sprung up in recent years. The study of the microbiota and the diversity of microorganisms in all parts of the human body gave rise to a new understanding of the development of many diseases and, accordingly, to the possibility of creating new therapeutic approaches. The microbiota of the bladder is no exception either. The mechanisms of the formation of asymptomatic bacteriuria (AB) and urinary tract infection (UTI) are of interest to many scientists. The presented article is devoted to the review of recent studies focused on the genetic, immune and molecular mechanisms of interaction between macro- and microorganisms in the development of UTI.

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The authors declare that there are no conflicts of interest present.