medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2015-8-82-85medsovet-233Research ArticleЭндокринологияEndocrinologyФармакогенетические аспекты пероральной сахароснижающей терапии. Фенотипы «ответа» и «провала»Pharmacogenetic aspects of oral hypoglycemic therapy. Response and failure phenotypesСорокинаЮ. А.SorokinaY. A.noemail@neicon.ruНижегородская государственная медицинская академия Минздрава РоссииРоссияNizhniy Novgorod State Medical Academy, Russia's Ministry of HealthRussian Federation201530122015088285Copyright © Сорокина Ю.А., 20152015Сорокина Ю.А.Sorokina Y.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/233

В данной работе была сделана попытка ответить на вопрос о возможности эффективной персонифицированной сахароснижающей терапии, в частности метформином, у пациентов c сахарным диабетом 2-го типа с учетом однонуклеотидного полиморфизма трех генов (эндотелиальная синтаза оксида азота, 8-оксогуанин-ДНК-гликозилаза, блок р53). Предполагается, что эффективность использования метформина зависит, в частности, от наличия полиморфизма данных генов.

The research work attempted to answer the question whether an effective personalized glucose-lowering therapy, particularly with metformin, is possible in patients with type 2 diabetes based on single nucleotide polymorphism of the three genes (endothelial nitric oxide synthase, 8-oxoguanine DNA glycosylase and p53). Metformin efficacy could depend, in particular, on the presence of polymorphism in these genes.

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The authors declare that there are no conflicts of interest present.