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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2018-5-8-14</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-2345</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АРТЕРИАЛЬНАЯ ГИПЕРТЕНЗИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ARTERIAL HYPERTENSION</subject></subj-group></article-categories><title-group><article-title>Новый вектор в лечении артериальной гипертонии: американские рекомендации – 2017</article-title><trans-title-group xml:lang="en"><trans-title>New perspectives for the treatment of arterial hypertension: 2017 american guidelines</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карпов</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Karpov</surname><given-names>Yu. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><bio xml:lang="en"><p>MD.Prof.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр кардиологии Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Centre of Cardiology of the Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>10</day><month>04</month><year>2018</year></pub-date><volume>0</volume><issue>5</issue><fpage>8</fpage><lpage>14</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Карпов Ю.А., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Карпов Ю.А.</copyright-holder><copyright-holder xml:lang="en">Karpov Y.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/2345">https://www.med-sovet.pro/jour/article/view/2345</self-uri><abstract><p>Основной задачей лечения пациентов с АГ является снижение риска развития сердечно-сосудистых осложнений через достижение целевого уровня артериального давления (АД) и органопротекции, лечение сопутствующих заболеваний и коррекцию факторов риска. В недавно представленных новых американских рекомендациях по ведению пациентов АГ указывается, что целевым уровнем АД для всех пациентов стало меньше 130/80 мм рт. ст. Это связано в т. ч. с изменением классификации уровней АД и признания пациентами АГ всех взрослых лиц с АД 130/80 мм рт. ст. и выше. Необходимость не только более широкого проведения комбинированной терапии в лечении пациентов АГ, но и более раннего ее приме- нения нашла весьма яркое подтверждение в этих новых рекомендациях по ведению пациентов АГ. Более широкое при- менение комбинаций, особенно в фиксированных дозах, как блокатора кальциевых каналов амлодипина, так и блокатора рецепторов ангиотензина II олмесартана в лечении АГ будет способствовать улучшению контроля АД, снижению риска осложнений и увеличению продолжительности жизни больных АГ.</p></abstract><trans-abstract xml:lang="en"><p>The key goal in the treatment for patients with AH is to reduce the risk of cardiovascular complications through reaching the target level of arterial pressure (AP) and organ protection, treatment of concomitant diseases and correction of risk factors. The new US guidelines for the management of hypertension indicate that the target blood pressure level for all patients was less than 130/80 mm Hg. This is due, among other things, to changing the blood pressure levels classification and categorizing all adults with blood pressure of 130/80 mm Hg. and higher as having hypertension. The need for not only wider combination therapy for the treatment of hypertensive patients, but also its earlier commencement has been strongly confirmed by these new guidelines for the management of AH. The wider use of combinations, especially in fixed doses, such as the calcium channel blocker amlodipine, and the angiotensin II receptor antagonist olmesartan for the treatment of hypertension, will help improve blood pressure monitoring, reduce the risk of complications and increase the AH patients’ life expectancy.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>артериальная гипертония</kwd><kwd>рекомендации</kwd><kwd>целевые уровни АД</kwd><kwd>лечение АГ</kwd></kwd-group><kwd-group xml:lang="en"><kwd>arterial hypertension</kwd><kwd>recommendations</kwd><kwd>target blood pressure levels</kwd><kwd>treatment of hypertension</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Чазова И.Е., Жернакова Ю.В., Ощепкова Е.В. и соавт. Распространенность факторов риска сердечно-сосудистых заболеваний в российской популяции больных АГ. Кардиология 2014, 10: 4-12.</mixed-citation><mixed-citation xml:lang="en">Chazova IE, Zhernakova YuV, Oschepkova EV, et al. The prevalence of cardiovascular risk factors in the Russian population of patients with AH. Kardiologiya 2014, 10: 4-12.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Клинические рекомендации «Диагностика и лечение артериальной гипертензии» Российского медицинского общества по артериальной гипертонии. Кардиологический вестник, 2015, 1(10): 5-30.</mixed-citation><mixed-citation xml:lang="en">Clinical Guidelines for the Diagnosis and Treatment of Hypertension of the Russian Medical Society on Arterial Hypertension. Kardiologicheskiy Vestnik, 2015, 1 (10): 5-30.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Mancia G, Fagard R, Narkiewicz K, et al. Task Force Members. 2013 ESH/ESC Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens, 2013, 31(7): 1281–1357.</mixed-citation><mixed-citation xml:lang="en">Mancia G, Fagard R, Narkiewicz K, et al. Task Force Members. 2013 ESH/ESC Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens, 2013, 31(7): 1281–1357.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Wright JT Jr, Williamson JD, Whelton PK, et al.A randomized trial of intensive versus standard blood-pressure control. SPRINT Research Group. N Engl J Med, 2015, 373: 2103-16.</mixed-citation><mixed-citation xml:lang="en">Wright JT Jr, Williamson JD, Whelton PK, et al.A randomized trial of intensive versus standard blood-pressure control. SPRINT Research Group. N Engl J Med, 2015, 373: 2103-16.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Piepoli MF, Hoes AW, Agewall S, et al. Authors/ Task Force Members. 2016 European Guidelines on cardiovascular disease prevention in clinical practice. The Sixth Joint Task Force of the European Society of Cardiology and other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts) developed with the special contribution of the European Association for Cardiovascular Prevention &amp; Rehabilitation (EACPR). Eur Heart J, 2016, 37: 2315–2381.</mixed-citation><mixed-citation xml:lang="en">Piepoli MF, Hoes AW, Agewall S, et al. Authors/ Task Force Members. 2016 European Guidelines on cardiovascular disease prevention in clinical practice. The Sixth Joint Task Force of the European Society of Cardiology and other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts) developed with the special contribution of the European Association for Cardiovascular Prevention &amp; Rehabilitation (EACPR). Eur Heart J, 2016, 37: 2315–2381.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Whelton PK, Carey RM, Aronow WS, Casey Jr DE, Collins KJ, Dennison, Himmelfarb C, DePalma SM, Gidding S, Jamerson KA, Jones DW, Mac Laughlin EJ, Muntner P, Ovbiagele B, Smith Jr SC, Spencer CC, Stafford RS, Taler SJ, Thomas RJ, Williams Sr KA, Williamson JD, Wright Jr JT, 2017 ACC/AHA/AAPA/ABC/ACPM/ AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults. JACC, 2017. doi: 10.1016/j. jacc.2017.11.006.</mixed-citation><mixed-citation xml:lang="en">Whelton PK, Carey RM, Aronow WS, Casey Jr DE, Collins KJ, Dennison, Himmelfarb C, DePalma SM, Gidding S, Jamerson KA, Jones DW, Mac Laughlin EJ, Muntner P, Ovbiagele B, Smith Jr SC, Spencer CC, Stafford RS, Taler SJ, Thomas RJ, Williams Sr KA, Williamson JD, Wright Jr JT, 2017 ACC/AHA/AAPA/ABC/ACPM/ AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults. JACC, 2017. doi: 10.1016/j. jacc.2017.11.006.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Gupta AK, Arshad S, Poulter NR. Compliance, safety, and effectiveness of fixed-dose combinations of antihypertensive agents: a meta-analysis. Hypertension. 2010, 55: 399–407.</mixed-citation><mixed-citation xml:lang="en">Gupta AK, Arshad S, Poulter NR. Compliance, safety, and effectiveness of fixed-dose combinations of antihypertensive agents: a meta-analysis. Hypertension. 2010, 55: 399–407.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Puchler K, Laies P, Stumpe K. Blood pressure response, but not adverse event incidence, correlates with dose of angiotensin II antagonist.J Hypertens, 2001, 19(Suppl.): S41-S48.</mixed-citation><mixed-citation xml:lang="en">Puchler K, Laies P, Stumpe K. Blood pressure response, but not adverse event incidence, correlates with dose of angiotensin II antagonist.J Hypertens, 2001, 19(Suppl.): S41-S48.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Punzi HA. Efficacy and safety of olmesartan medoxomil alone and in combination with hydrochlorothiazide. Expert Rev Cardiovasc Ther, 2009, 7: 229-239.</mixed-citation><mixed-citation xml:lang="en">Punzi HA. Efficacy and safety of olmesartan medoxomil alone and in combination with hydrochlorothiazide. Expert Rev Cardiovasc Ther, 2009, 7: 229-239.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Norwood D, Branch E, Smith B et al. Olmesartan medoxomil for hypertension: a clinical review. Drug. Forecast., 2002, 27: 611-618</mixed-citation><mixed-citation xml:lang="en">Norwood D, Branch E, Smith B et al. Olmesartan medoxomil for hypertension: a clinical review. Drug. Forecast., 2002, 27: 611-618</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Brunner HR, Stumpe KO, Januszewicz A. Antihypertensive efficacy of olmesartan medoxomil and candesartan cilexitil assessed by 24-hour ambulatory blood pressure monitoring in patients with essential hypertension. Clin Drug Invest, 2003, 23: 419-430.</mixed-citation><mixed-citation xml:lang="en">Brunner HR, Stumpe KO, Januszewicz A. Antihypertensive efficacy of olmesartan medoxomil and candesartan cilexitil assessed by 24-hour ambulatory blood pressure monitoring in patients with essential hypertension. Clin Drug Invest, 2003, 23: 419-430.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Oparil S, Williams D, Chrysant SG et al. Comparative efficacy of olmesartan, losartan, valsartan, and irbesartan in the control of essential hypertension. J Clin Hypertens, 2001, 3: 283-291.</mixed-citation><mixed-citation xml:lang="en">Oparil S, Williams D, Chrysant SG et al. Comparative efficacy of olmesartan, losartan, valsartan, and irbesartan in the control of essential hypertension. J Clin Hypertens, 2001, 3: 283-291.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Williams P.A. A multi-centre, double-blind, efficacy, tolerability and safety study of the oral angiotensin II antagonist olmesartan medoxomil versus captopril in patients with mild to moderate essential hypertension. J Hypertens, 2001, 19(suppl. 2): 300.</mixed-citation><mixed-citation xml:lang="en">Williams P.A. A multi-centre, double-blind, efficacy, tolerability and safety study of the oral angiotensin II antagonist olmesartan medoxomil versus captopril in patients with mild to moderate essential hypertension. J Hypertens, 2001, 19(suppl. 2): 300.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Haller H, Sadayoshi I, Izzo JL, et al. Olmesartan for the delay or prevention of microalbuminuria in type 2 diabetes. N Engl J Med, 2011, 364: 907-17.</mixed-citation><mixed-citation xml:lang="en">Haller H, Sadayoshi I, Izzo JL, et al. Olmesartan for the delay or prevention of microalbuminuria in type 2 diabetes. N Engl J Med, 2011, 364: 907-17.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Sever PS, Dahlof B, Poulter NR, et al, for the ASCOT Investigators. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT-BPLA): a multicentre randomized controlled trial. Lancet, 2005, 366: 895-906.</mixed-citation><mixed-citation xml:lang="en">Sever PS, Dahlof B, Poulter NR, et al, for the ASCOT Investigators. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT-BPLA): a multicentre randomized controlled trial. Lancet, 2005, 366: 895-906.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Julius S, Kjeldsen SE, Weber M, et al. Outcomes in hypertensive patients at high cardiovascular risk treated with valsartan- or amlodipine-based regimens: VALUE, a randomised trial. Lancet, 2004, 363: 2022-31.</mixed-citation><mixed-citation xml:lang="en">Julius S, Kjeldsen SE, Weber M, et al. Outcomes in hypertensive patients at high cardiovascular risk treated with valsartan- or amlodipine-based regimens: VALUE, a randomised trial. Lancet, 2004, 363: 2022-31.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Pitt B, Byington RP, Furberg CD, et al. Effect of amlodipine on the progression of atherosclerosis and the occurrence of clinical events. Circulation, 2000, 102: 1503-1510.</mixed-citation><mixed-citation xml:lang="en">Pitt B, Byington RP, Furberg CD, et al. Effect of amlodipine on the progression of atherosclerosis and the occurrence of clinical events. Circulation, 2000, 102: 1503-1510.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Nissen SE, Tuzcu EM, Libby P, et al. Effect of antihypertensive agents on cardiovascular events in patients with coronary disease and normal blood pressure. The CAMELOT study: a randomized controlled trial. JAMA, 2004, 292: 2217-2226.</mixed-citation><mixed-citation xml:lang="en">Nissen SE, Tuzcu EM, Libby P, et al. Effect of antihypertensive agents on cardiovascular events in patients with coronary disease and normal blood pressure. The CAMELOT study: a randomized controlled trial. JAMA, 2004, 292: 2217-2226.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">The ALLHAT Officers and Coordinators. Major outcomes in high-risk hypertensive patients randomized to ACE inhibitor or calcium channel blocker vs diuretic (ALLHAT). JAMA, 2002, 288: 2981-2997.</mixed-citation><mixed-citation xml:lang="en">The ALLHAT Officers and Coordinators. Major outcomes in high-risk hypertensive patients randomized to ACE inhibitor or calcium channel blocker vs diuretic (ALLHAT). JAMA, 2002, 288: 2981-2997.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Jamerson K, Weber MA, Bakris GL, et al. Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients.N Engl J Med, 2008, 359(23): 2417-28.</mixed-citation><mixed-citation xml:lang="en">Jamerson K, Weber MA, Bakris GL, et al. Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients.N Engl J Med, 2008, 359(23): 2417-28.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Chrysant S, Melino M, Karki S, Lee J, Heyrman R. The combination of olmesartan medoxomil and amlodipine besylate in controlling high blood pressure: COACH, a randomized, double-blind, placebocontrolled, 8-week factorial efficacy and safety study. Clin Ther, 2008, 30(4): 587–604.</mixed-citation><mixed-citation xml:lang="en">Chrysant S, Melino M, Karki S, Lee J, Heyrman R. The combination of olmesartan medoxomil and amlodipine besylate in controlling high blood pressure: COACH, a randomized, double-blind, placebocontrolled, 8-week factorial efficacy and safety study. Clin Ther, 2008, 30(4): 587–604.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Volpe M, Brommer P, Haag U, Miele C. Efficacy and tolerability of olmesartan medoxomil combined with amlodipine in patients with moderate to severe hypertension after amlodipine monotherapy: a randomized, double-blind, parallel-group, multicentre study. Clin Drug Investig, 2009, 29(1): 11–25.</mixed-citation><mixed-citation xml:lang="en">Volpe M, Brommer P, Haag U, Miele C. Efficacy and tolerability of olmesartan medoxomil combined with amlodipine in patients with moderate to severe hypertension after amlodipine monotherapy: a randomized, double-blind, parallel-group, multicentre study. Clin Drug Investig, 2009, 29(1): 11–25.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Barrios V, Brommer P, Haag U, Calderon A, Escobar C. Olmesartan medoxomil plus amlodi-pine increases efficacy in patients with moderate-to-severe hypertension after monotherapy: a randomized, double-blind, parallel-group, multicentre study. Clin Drug Investig, 2009, 29(7): 427–439.</mixed-citation><mixed-citation xml:lang="en">Barrios V, Brommer P, Haag U, Calderon A, Escobar C. Olmesartan medoxomil plus amlodi-pine increases efficacy in patients with moderate-to-severe hypertension after monotherapy: a randomized, double-blind, parallel-group, multicentre study. Clin Drug Investig, 2009, 29(7): 427–439.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Weir MR, Hsueh WA, Nesbitt SD, et al. Effects on BP control of amlodipine/olmesartan medoxomil, with or without hydrochlorothiazide, in patients not controlled by prior anti-hypertensive monotherapy (late breaker at the American Society of Hypertension 25th Annual Scentific Meeting, New York). J Clin Hypertens (Greenwich), 2010, 12(7): 536.</mixed-citation><mixed-citation xml:lang="en">Weir MR, Hsueh WA, Nesbitt SD, et al. Effects on BP control of amlodipine/olmesartan medoxomil, with or without hydrochlorothiazide, in patients not controlled by prior anti-hypertensive monotherapy (late breaker at the American Society of Hypertension 25th Annual Scentific Meeting, New York). J Clin Hypertens (Greenwich), 2010, 12(7): 536.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Punzi H, Neutel JM, Kereiakes DJ, et al. Efficacy of amlodipine and olmesartan medoxomil in patients with hypertension: the AZOR Trial Evaluating Blood Pressure Reductions and Control (AZTEC) study. Ther Adv Cardiovasc Dis, 2010, 4(4): 209–221.</mixed-citation><mixed-citation xml:lang="en">Punzi H, Neutel JM, Kereiakes DJ, et al. Efficacy of amlodipine and olmesartan medoxomil in patients with hypertension: the AZOR Trial Evaluating Blood Pressure Reductions and Control (AZTEC) study. Ther Adv Cardiovasc Dis, 2010, 4(4): 209–221.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
