medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2018-5-65-69medsovet-2359Research ArticleСердечная недостаточностьHeart failureВлияние терапии триметазидином на состояние магистральных сосудов и микроциркуляцию у больных ХСН и СД 2-го типа результаты оригинального исследованияInfluence of therapy with trimetazidine on the state of the main vessels and microcirculation in patients with CHF and DM type 2. The results of the original studyСтаценкоМ. Е.StatsenkoM. E.

д.м.н., профессор

MD, Prof.

ФабрицкаяС. В.FabritskayaS. V.

к.м.н.

PhD in medicine

РындинаЮ. А.RyndinaU. A.Волгоградский государственный медицинский университет Минздрава РоссииРоссия201811042018056569Copyright © Стаценко М.Е., Фабрицкая С.В., Рындина Ю.А., 20182018Стаценко М.Е., Фабрицкая С.В., Рындина Ю.А.Statsenko M.E., Fabritskaya S.V., Ryndina U.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/2359

Эндотелиальная дисфункция играет определяющую роль в патогенезе поражения органов-мишеней у пациентов с хронической сердечной недостаточностью (ХСН) и сахарным диабетом (СД) 2-го типа. Цель исследования: оценить влияние триметазидина на показатели эластичности магистральных артерий и микроциркуляции (МЦ) у больных ХСН и СД 2-го типа. Включено 60 больных ХСН в сочетании с СД 2-го типа в возрасте 45–70 лет. Все пациенты получали препараты базисной терапии ХСН и СД. Пациентам 1-й группы (n = 30) в дополнение к традиционному лечению назначен триметазидин в дозе 70 мг/сут. Оценивали эластические свойства крупных артерий путем анализа скорости распространения пульсовой волны (СРПВ), изучали показатели МЦ. Результаты. Через 16 недель лечения выявлена способность триметазидина достоверно улучшать эндотелиальную функцию, состояние микрососудистого русла, уменьшать жесткость сосудистой стенки и благоприятно влиять на клиническое состояние пациентов.

Endothelial dysfunction plays a major role in the pathogenesis of target organ damage in patients with chronic heart failure (CHF) and type 2 diabetes mellitus (DM). The aim of the study was to evaluate the effect of trimetazidine on the parameters of the elasticity of the large arteries and microcirculation (MC) in patients with CHF and type 2 diabetes. 60 diabetic patients with CHF at the age of 45–70 years were included. All patients received baseline therapy of CHF and DM. Trimetazidine at a dose of 70 mg / day was prescribed for all patients of 1 group (n = 30) in addition to traditional treatment. The elastic properties of large arteries were evaluated by analyzing the velocity of the pulse wave propagation (SRV), and the MC parameters were studied. Results. Treatment with using of trimetazidine in addition to traditional treatment for 16 weeks significantly improved endothelial function, clinical state of patientsфтв the state of the parameters of the microcirculation.

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The authors declare that there are no conflicts of interest present.