medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2018-5-76-84medsovet-2361Research ArticleКоморбидный пациентComorbid patientОсновные принципы первичной профилактики сахарного диабета 2-го типаBasic principles of primary prevention of type 2 diabetes mellitusШепельР. Н.ShepelR. N.Национальный медицинский исследовательский центр профилактической медицины Минздрава России, МоскваРоссияNational Medical Research Center for Preventive Medicine of Health of Russia, MoscowRussian Federation201811042018057684Copyright © Шепель Р.Н., 20182018Шепель Р.Н.Shepel R.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/2361

Сахарный диабет 2-го типа является одной из основных проблем здравоохранения не только в нашей стране, но и в мире. В условиях неуклонного роста числа больных диабетом крайне важно уделять должное внимание профилактическим мероприятиям, направленным на снижение распространенности сахарного диабета 2-го типа. В статье описаны основные принципы первичной немедикаментозной профилактики сахарного диабета 2-го типа.

 

Type 2 diabetes mellitus is one of the main health problems not only in our country, but also in the world. Due to the steady rise in the number of persons with DM, it is extremely important to pay due attention to preventive measures aimed at reducing the prevalence of type 2 diabetes. The article describes the main principles of primary non-drug prevention of type 2 diabetes mellitus.

сахарный диабет 2-го типапрофилактикапреддиабетфакторы рискаглюкометрыtype 2 diabetes mellituspreventionprediabetesrisk factorsglucometersReferencesIDF Diabetes Atlas. 8-th edition. 2017.IDF Diabetes Atlas. 8-th edition. 2017.Дедов И.И., Шестакова М.В., Викулова О.К. Эпидемиология сахарного диабета в Российской Федерации: клинико-статистический отчет по данным Федерального регистра сахарного диабета. Сахарный диабет, 2017, 20(1): 13-41Dedov II, Shestakova MV, Vikulova OK. Epidemiology of diabetes mellitus in the Russian Federation: a clinical and statistical report based on the Federal Register of Diabetes Mellitus. Sakharny Diabet, 2017, 20 (1): 13-41.Dedov I, Shestakova M, Benedetti MM, et al. Prevalence of type 2 diabetes mellitus in the adult Russian population (NATION study). Diabetes Res Clin Pract, 2016, 115: 90-95.Dedov I, Shestakova M, Benedetti MM, et al. Prevalence of type 2 diabetes mellitus in the adult Russian population (NATION study). Diabetes Res Clin Pract, 2016, 115: 90-95.Дедов И.И., Концевая А.В., Шестакова М.В. и др. Экономические затраты на сахарный диабет 2 типа и его основные сердечно-сосудистые осложнения в Российской Федерации. Сахарный диабет, 2016, 19(6): 518-527Dedov II, Kontsevaya AV, Shestakova MV. The economic costs of type 2 diabetes mellitus and its major cardiovascular complications in the Russian Federation. Sakharny Diabet, 2016, 19 (6): 518-527.Williams DR. Race and health: basic questions, emerging directions. Ann Epidemiol, 1997, 7(5): 322–333.Williams DR. Race and health: basic questions, emerging directions. Ann Epidemiol, 1997, 7(5): 322–333.King H, Rewers M. Global estimates for prevalence of diabetes mellitus and impaired glucose tolerance in adults. WHO Ad Hoc Diabetes Reporting Group. Diabetes Care, 1993, 16: 157– 177.King H, Rewers M. Global estimates for prevalence of diabetes mellitus and impaired glucose tolerance in adults. WHO Ad Hoc Diabetes Reporting Group. Diabetes Care, 1993, 16: 157– 177.Wium C, Gulseth HL, Eriksen EF, Birkeland KI. Characteristics of glucose metabolism in Nordic and South Asian subjects with type 2 diabetes. PLoS One, 2013, 31: 8-12.Wium C, Gulseth HL, Eriksen EF, Birkeland KI. Characteristics of glucose metabolism in Nordic and South Asian subjects with type 2 diabetes. PLoS One, 2013, 31: 8-12.Piccolo RS, Duncan DT, Pearce N, McKinlay JB. The role of neighborhood characteristics in racial/ethnic disparities in type 2 diabetes: results from the Boston Area Community Health (BACH) Survey. Soc. Sci. Med, 2015, 130: 79-90.Piccolo RS, Duncan DT, Pearce N, McKinlay JB. The role of neighborhood characteristics in racial/ethnic disparities in type 2 diabetes: results from the Boston Area Community Health (BACH) Survey. Soc. Sci. Med, 2015, 130: 79-90.Никитин Ю.П., Воевода М.И., Симонова Г.И. Сахарный диабет и метаболический синдром в Сибири и на Дальнем Востоке. Вестник РАМН, 2012, 1: 66-74.Nikitin YuP, Voevoda MI, Simonova GI. Diabetes mellitus and metabolic syndrome in Siberia and the Far East. Vestnik RAMN, 2012, 1: 66-74.Сыдыкова Л.А., Гагарин В.И. Особенности сахарного диабета 2 типа у коренного населения Севера. Современные наукоемкие технологии, 2006, 7: 62-64.Sydykova LA, Gagarin VI. Features of type 2 diabetes in the indigenous population of the North. Sovremennyye Naukoyemkiye Tekhnologii, 2006, 7: 62-64.Дедов И.И., Шестакова М.В., Галстян Г.Р. Распространенность сахарного диабета 2 типа у взрослого населения России (исследование NATION). Сахарный диабет, 2016, 19(2): 104-112.Dedov II, Shestakova MV, Galstyan GR. The prevalence of type 2 diabetes in the adult population of Russia (NATION study). Sakharny Diabet, 2016, 19 (2): 104-112.McCarthy M, Menzel S. The genetics of type 2 diabetes. Br J Clin Pharmacol, 2001, 51(3): 195-199.McCarthy M, Menzel S. The genetics of type 2 diabetes. Br J Clin Pharmacol, 2001, 51(3): 195-199.Flores JC, Hirschhorn J, Altshuler D. The inherited basis of diabetes mellitus: implications for the genetic analysis of complex traits. Annu Rev Genomics Hum Genet, 2003, 4: 257-291.Flores JC, Hirschhorn J, Altshuler D. The inherited basis of diabetes mellitus: implications for the genetic analysis of complex traits. Annu Rev Genomics Hum Genet, 2003, 4: 257-291.Hansen L. Candidate genes and late-onset type 2 diabetes mellitus. Susceptibility genes or common polymorphisms? Dan Med Bull, 2003, 50: 320-346.Hansen L. Candidate genes and late-onset type 2 diabetes mellitus. Susceptibility genes or common polymorphisms? Dan Med Bull, 2003, 50: 320-346.Gloyn AL. The search for type 2 diabetes genes. Ageing Res Rev, 2003, 2: 111-127.Gloyn AL. The search for type 2 diabetes genes. Ageing Res Rev, 2003, 2: 111-127.Barroso I, Luan J, Middelberg RPS, et al. Candidate gene association study in type 2 diabetes indicates a role for genes involved in B-Cell function as well as insulin action. PLoS Biol, 2003, 1: 41-55.Barroso I, Luan J, Middelberg RPS, et al. Candidate gene association study in type 2 diabetes indicates a role for genes involved in B-Cell function as well as insulin action. PLoS Biol, 2003, 1: 41-55.Cox NJ, Hayes MG, Roe CA, et al. Linkage of cal-pain 10 to type 2 diabetes: the biological rationale. Diabetes, 2004, 53: S19-S25.Cox NJ, Hayes MG, Roe CA, et al. Linkage of cal-pain 10 to type 2 diabetes: the biological rationale. Diabetes, 2004, 53: S19-S25.Valsania P, Micossi P. Genetic epidemiology of non-insulin-dependent diabetes. Diabetes Metab Rev, 1994, 10: 385–405.Valsania P, Micossi P. Genetic epidemiology of non-insulin-dependent diabetes. Diabetes Metab Rev, 1994, 10: 385–405.Gerich JE. The genetic basis of type 2 diabetes mellitus: impaired insulin secretion versus impaired insulin sensitivity. Endocr Rev, 1998, 19: 491–503.Gerich JE. The genetic basis of type 2 diabetes mellitus: impaired insulin secretion versus impaired insulin sensitivity. Endocr Rev, 1998, 19: 491–503.Платонов Ф.А., Осаковский В.Л. и др. Маркеры генетической предрасположенно-сти к сахарному диабету 2 типа в якутской популяции. Сборник тезисов VII Всерос-сийского диабетологического конгресса. 2015. С. 43Platonov FA, Osakovski VL, et al. Genetic markers of predisposition to type 2 diabetes mellitus in the Yakut population. Collection of theses of the 7th All-Russian Diabetologic Congress. 2015. P. 43.Menke A, Casagrande S, Geiss L, et al. Prevalence of and Trends in Diabetes Among Adults in the United States, 1988-2012. JAMA, 2015, 314(10): 1021-1029.Menke A, Casagrande S, Geiss L, et al. Prevalence of and Trends in Diabetes Among Adults in the United States, 1988-2012. JAMA, 2015, 314(10): 1021-1029.Дедов И.И., Шестакова М.В. Алгоритмы специализированной медицинской помощи больным сахарным диабетом. М., 2017.Dedov II, Shestakova MV. Standards of specialized medical care in diabetes. M., 2017Wandell PE, Carlsson AC. Gender differences and time trends in incidence and prevalence of type 2 diabetes in Sweden-a model explaining the diabetes epidemic worldwide today? Diabetes Res Clin Pract, 2014, 106(3): e90-92.Wandell PE, Carlsson AC. Gender differences and time trends in incidence and prevalence of type 2 diabetes in Sweden-a model explaining the diabetes epidemic worldwide today? Diabetes Res Clin Pract, 2014, 106(3): e90-92.Sattar N. Gender aspects in type 2 diabetes mellitus and cardiometabolic risk. Best Pract Res Clin Endocrinol Metab, 2013, 27(4): 501-507.Sattar N. Gender aspects in type 2 diabetes mellitus and cardiometabolic risk. Best Pract Res Clin Endocrinol Metab, 2013, 27(4): 501-507.Ehrenberg HM, Mercer BM, Catalano PM: The influence of obesity and diabetes on the prevalence of macrosomia. Am J Obstet Gynecol, 2004, 191: 964-968.Ehrenberg HM, Mercer BM, Catalano PM: The influence of obesity and diabetes on the prevalence of macrosomia. Am J Obstet Gynecol, 2004, 191: 964-968.Jovanovic-Peterson L, Peterson CM, Reed GF, Metzger BE, Mills JL, Knopp RH, et al. Maternal postprandial glucose levels and infant birth weight: the Diabetes in Early Pregnancy Study. The National Institute of Child Health and Human Development-Diabetes in Early Pregnancy Study. Am J Obstet Gynecol, 1991, 164: 103-111.Jovanovic-Peterson L, Peterson CM, Reed GF, Metzger BE, Mills JL, Knopp RH, et al. Maternal postprandial glucose levels and infant birth weight: the Diabetes in Early Pregnancy Study. The National Institute of Child Health and Human Development-Diabetes in Early Pregnancy Study. Am J Obstet Gynecol, 1991, 164: 103-111.KC K, Shakya S, Zhang H, Gestational Diabetes Mellitus and Macrosomia: A Literature Review. Ann Nutr Metab, 2015, 66(suppl 2): 14-20.KC K, Shakya S, Zhang H, Gestational Diabetes Mellitus and Macrosomia: A Literature Review. Ann Nutr Metab, 2015, 66(suppl 2): 14-20.Hunter DJ, Burrows RF, Mohide PT, Whyte RK. Influence of maternal insulin-dependent diabetes mellitus on neonatal morbidity. CMAJ, 1993, 149: 47-52.Hunter DJ, Burrows RF, Mohide PT, Whyte RK. Influence of maternal insulin-dependent diabetes mellitus on neonatal morbidity. CMAJ, 1993, 149: 47-52.Simmons D. Interrelation between umbilical cord serum sex hormones, sex hormone-binding globulin, insulin-like growth factor I, and insulin in neonates from normal pregnancies and pregnancies complicated by diabetes. J Clin Endocrinol Metab, 1995, 80: 2217-2221.Simmons D. Interrelation between umbilical cord serum sex hormones, sex hormone-binding globulin, insulin-like growth factor I, and insulin in neonates from normal pregnancies and pregnancies complicated by diabetes. J Clin Endocrinol Metab, 1995, 80: 2217-2221.Мудров М.А., Молчанова Н.В., Пономарева Ю.Н., Мудров А.А. Возможности диагностики макросомии плода на современном этапе. Журнал акушерства и женских болезней, 2016, 565 (5): 75-81.Mudrov MA, Molchanova NV, Ponomareva YuN, Mudrov AA. Possibilities for diagnosis of fetal macrosomia at the present stage. Zhurnal Akusherstva i Zhenskikh Bolezney, 2016, 565 (5): 75-81.Yumuk V, Tsigos C, Fried M, Schindler K, Busetto L, Micic D, Toplak H. Obesity Management Task Force of the European Association for the Study of Obesity European guidelines for obesity management in adults. Obes Facts, 2015, 8: 402–424.Yumuk V, Tsigos C, Fried M, Schindler K, Busetto L, Micic D, Toplak H. Obesity Management Task Force of the European Association for the Study of Obesity European guidelines for obesity management in adults. Obes Facts, 2015, 8: 402–424.WHO Obesity and Overweight. Fact sheet No.311. 2016. www.who.int/mediacentre/fact-sheets/fs311/en/ (accessed date 28.02.2018).WHO Obesity and Overweight. Fact sheet No.311. 2016. www.who.int/mediacentre/fact-sheets/fs311/en/ (accessed date 28.02.2018).Шальнова С.А., Деев А.Д., Баланова Ю.А. и др. Двадцатилетние тренды ожирения и артериальной гипертонии и их ассоциации в России. Кардиоваскулярная терапия и профилактика, 2017, 16(4): 4-10Shalnova SA, Deev AD, Balanova YuA, et al. Twenty-year trends in obesity and hypertension and their associations in Russia. Kardiovaskulyarnaya Terapiya i Profilaktika, 2017, 16 (4): 4-10.Colditz GA, Willett WC, Stampfer MJ, Manson JE, Hennekens CH, Arky RA, Speizer FE. Weight as a risk factor for clinical diabetes in women. American Journal of Epidemiology, 1990, 132: 501–13.Colditz GA, Willett WC, Stampfer MJ, Manson JE, Hennekens CH, Arky RA, Speizer FE. Weight as a risk factor for clinical diabetes in women. American Journal of Epidemiology, 1990, 132: 501–13.Gang H, Lindström J, Valle TT, et al. Physical activity, body mass index, and risk of type 2 diabetes in patients with normal or impaired glucose regulation. Arch Intern Med, 2004, 164(8): 892-896.Gang H, Lindström J, Valle TT, et al. Physical activity, body mass index, and risk of type 2 diabetes in patients with normal or impaired glucose regulation. Arch Intern Med, 2004, 164(8): 892-896.Yang H, Xin Z, Feng PG, Yang GK. Waist-to-height ratio is better than body mass index and waist circumference as a screening criterion for metabolic syndrome in Han Chinese adults. Medicine (Baltimore), 2017, 96(39): e8192.Yang H, Xin Z, Feng PG, Yang GK. Waist-to-height ratio is better than body mass index and waist circumference as a screening criterion for metabolic syndrome in Han Chinese adults. Medicine (Baltimore), 2017, 96(39): e8192.Fujita M, Sato Y, Nagashima K, Takahashi S, Hata A. Predictive power of a body shape index for development of diabetes, hypertension, and dyslipidemia in Japanese adults: a retrospective cohort study. PLoS One, 2015, 10: e0128972.Fujita M, Sato Y, Nagashima K, Takahashi S, Hata A. Predictive power of a body shape index for development of diabetes, hypertension, and dyslipidemia in Japanese adults: a retrospective cohort study. PLoS One, 2015, 10: e0128972.Freemantle N, Holmes J, Hockey A, Kumar S. How strong is the association between abdominal obesity and the incidence of type 2 diabetes? Int J Clin Pract, 2008, 62: 1391–1396.Freemantle N, Holmes J, Hockey A, Kumar S. How strong is the association between abdominal obesity and the incidence of type 2 diabetes? Int J Clin Pract, 2008, 62: 1391–1396.Colditz GA, Willett WC, Rotnitzky A, Manson JE. Weight gain as a risk factor for clinical diabetes mellitus in women. Ann Intern Med, 1995, 122(7): 481-486.Colditz GA, Willett WC, Rotnitzky A, Manson JE. Weight gain as a risk factor for clinical diabetes mellitus in women. Ann Intern Med, 1995, 122(7): 481-486.Koh-Banerjee P, Wang Y, et al. Changes in body weight and body fat distribution as risk factors for clinical diabetes in US men. Am J Epidemiol, 2004, 159(12): 1150-1159.Koh-Banerjee P, Wang Y, et al. Changes in body weight and body fat distribution as risk factors for clinical diabetes in US men. Am J Epidemiol, 2004, 159(12): 1150-1159.Драпкина О.М., Шепель Р.Н. Гиподинамия – болезнь века: низкая физическая активность как фактор риска заболеваний сердечно-сосудистой системы и преждевременного старения. Кардиология: новости, мнения, обучение, 2015, 3: 53–58Drapkina OM, Shepel RN. Hypodinamy is the disease of the century: low physical activity as a risk factor for cardiovascular system diseases and premature aging. Kardiologiya: Novosti, Mneniya, Obucheniye, 2015, 3: 53-58.Manson JE, Rimm EB, Stampfer MJ, et al. Physical activity and incidence of non-insulin-dependent diabetes mellitus in women. Lancet, 1991, 338: 774–778.Manson JE, Rimm EB, Stampfer MJ, et al. Physical activity and incidence of non-insulin-dependent diabetes mellitus in women. Lancet, 1991, 338: 774–778.Manson JE, Nathan DM, Krolewski AS, et al. A prospective study of exercise and incidence of diabetes among US male physicians. Journal of the American Medical Association, 1992, 268: 63–7.Manson JE, Nathan DM, Krolewski AS, et al. A prospective study of exercise and incidence of diabetes among US male physicians. Journal of the American Medical Association, 1992, 268: 63–7.Kriska AM, LaPorte RE, Pettitt DJ, et al. The association of physical activity with obesity, fat distribution and glucose intolerance in Pima Indians. Diabetologia, 1993, 36: 863–869.Kriska AM, LaPorte RE, Pettitt DJ, et al. The association of physical activity with obesity, fat distribution and glucose intolerance in Pima Indians. Diabetologia, 1993, 36: 863–869.Helmrich SP, Ragland DR, Leung RW, Paffenbarger RS Jr. Physical activity and reduced occurrence of non-insulindependent diabetes mellitus. New England Journal of Medicine, 1991, 325: 147–152.Helmrich SP, Ragland DR, Leung RW, Paffenbarger RS Jr. Physical activity and reduced occurrence of non-insulindependent diabetes mellitus. New England Journal of Medicine, 1991, 325: 147–152.Потемкина Р.А. Повышение физической активности населения России: современные подходы к разработке популяционных программ. Профилактическая медицина. 2014, 17(1): 6-11Potemkina RA. Increasing physical activity levels in the Russian Federation: modern approaches to development of population programs. Profilakticheskaya Meditsina. 2014, 17 (1): 6-11.Бубнова М.Г., Аронов Д.М. Методические рекомендации. Обеспечение физической активности граждан, имеющих ограничения в состоянии здоровья. КардиоСоматика, 2016, 7 (1): 5–50.Bubnova MG, Aronov DM. Guidelines. Ensuring the physical activity of citizens who have health restraints. KardioSomatika, 2016, 7 (1): 5-50.Драпкина О.М., Шепель Р.Н. Курение, длина теломер и сердечно-сосудистые заболевания. Кардиология, 2015, 55(10): 85–89Drapkina OM, Shepel RN. Smoking, telomere length and cardiovascular diseases. Kardiologiya, 2015, 55 (10): 85-89.Eliasson B, Attvall S et al. Smoking cessation improves insulin sensitivity in healthy middle-aged men. Eur J Clin Invest, 1997, 27(5): 450-456.Eliasson B, Attvall S et al. Smoking cessation improves insulin sensitivity in healthy middle-aged men. Eur J Clin Invest, 1997, 27(5): 450-456.Wannamethee SG, Shaper AG, et al. British Regional Heart Study. Smoking as a modifiable risk factor for type 2 diabetes in middle-aged men. Diabetes Care, 2001, 24(9): 1590-1595.Wannamethee SG, Shaper AG, et al. British Regional Heart Study. Smoking as a modifiable risk factor for type 2 diabetes in middle-aged men. Diabetes Care, 2001, 24(9): 1590-1595.Will JC, Galuska DA, et al. Cigarette smoking and diabetes mellitus: evidence of a positive association from a large prospective cohort study. Int J Epidemiol, 2001, 30(3): 540-546.Will JC, Galuska DA, et al. Cigarette smoking and diabetes mellitus: evidence of a positive association from a large prospective cohort study. Int J Epidemiol, 2001, 30(3): 540-546.Гамбарян М.Г., Калинина А.М. Оказание медицинской помощи по профилактике и отказу от курения. М., 2012. С. 37Gambaryan MG, Kalinina AM. Provision of medical assistance for smoking prevention and cessation. M., 2012. P. 37.Seidell JC. Dietary fat and obesity: An epidemiologic perspective. Am J Clin Nutr, 1998, 67(3 Suppl): 546S–550S.Seidell JC. Dietary fat and obesity: An epidemiologic perspective. Am J Clin Nutr, 1998, 67(3 Suppl): 546S–550S.Lumey LH, Van Poppel FW. The Dutch famine of 1944-45: Mortality and morbidity in past and present generations. Soc Hist Med, 1994, 7: 229–246.Lumey LH, Van Poppel FW. The Dutch famine of 1944-45: Mortality and morbidity in past and present generations. Soc Hist Med, 1994, 7: 229–246.Khatib O. Noncommunicable diseases: risk factors and regional strategies for prevention and care. East Mediterr Health J, 2004, 10: 778–88.Khatib O. Noncommunicable diseases: risk factors and regional strategies for prevention and care. East Mediterr Health J, 2004, 10: 778–88.van Dam RM, Rimm EB, Willett WC, Stampfer MJ, Hu FB. Dietary patterns and risk for type 2 diabetes mellitus in U.S. men. Ann. Intern. Med, 2002, 136: 201–209.van Dam RM, Rimm EB, Willett WC, Stampfer MJ, Hu FB. Dietary patterns and risk for type 2 diabetes mellitus in U.S. men. Ann. Intern. Med, 2002, 136: 201–209.Shu L, Shen XM, et al. Dietary patterns are associated with type 2 diabetes mellitus among middle-aged adults in Zhejiang Province, China. Nutr J., 2017, 16(1): 81.Shu L, Shen XM, et al. Dietary patterns are associated with type 2 diabetes mellitus among middle-aged adults in Zhejiang Province, China. Nutr J., 2017, 16(1): 81.Alberti KGMM, Zimmet PZ, Shaw JE.The metabolic syndrome – a new worldwide definition from the International Diabetes Federation Consensus. Lancet, 2005, 366: 1059-1062.Alberti KGMM, Zimmet PZ, Shaw JE.The metabolic syndrome – a new worldwide definition from the International Diabetes Federation Consensus. Lancet, 2005, 366: 1059-1062.Драпкина О.М., Шепель Р.Н., Деева Т.А. Оценка уровня галектина-3 у пациентов с метаболическим синдромом и ишемической болезнью сердца. Российский кардиологический журнал, 2017, (3): 30-36Drapkina OM, Shepel RN, Deeva TA. Evaluation of galectin-3 level in patients with metabolic syndrome and ischemic heart disease. Rossiyskiy Kardiologicheskiy Zhurnal, 2017, (3): 30-36Carmena R. Type 2 diabetes, dyslipidemia, and vascular risk: Rationale and evidence for correcting the lipid imbalance. Am Heart J, 2005, 150: 859-870.Carmena R. Type 2 diabetes, dyslipidemia, and vascular risk: Rationale and evidence for correcting the lipid imbalance. Am Heart J, 2005, 150: 859-870.Haffner SM, American Diabetes A: Management of dyslipidemia in adults with diabetes. Diabetes Care, 2003, 26(Suppl 1): S83-86.Haffner SM, American Diabetes A: Management of dyslipidemia in adults with diabetes. Diabetes Care, 2003, 26(Suppl 1): S83-86.Christiane L, Haase CL, et al. HDL cholesterol and risk of type 2 diabetes: a Mendelian Randomization Study. Diabetes, 2015, 64(9): 3328-3333.Christiane L, Haase CL, et al. HDL cholesterol and risk of type 2 diabetes: a Mendelian Randomization Study. Diabetes, 2015, 64(9): 3328-3333.Gupta AK, Dahlof B, Dobson J, Sever PS, Wedel H, Poulter NR. Аnglo-scandinavian cardiac outcomes trial investigators . Determinants of new-onset diabetes among 19,257 hypertensive patients randomized in the anglo-scandinavian cardiac outcomes trial-blood pressure lowering arm and the relative influence of antihypertensive medication. Diabetes Care, 2008, 31: 982–988.Gupta AK, Dahlof B, Dobson J, Sever PS, Wedel H, Poulter NR. Аnglo-scandinavian cardiac outcomes trial investigators . Determinants of new-onset diabetes among 19,257 hypertensive patients randomized in the anglo-scandinavian cardiac outcomes trial-blood pressure lowering arm and the relative influence of antihypertensive medication. Diabetes Care, 2008, 31: 982–988.Lindholm LH, Ibsen H, Borch-Johnsen K, et al, LIFE study group. Risk of new-onset diabetes in the losartan intervention for endpoint reduction in hypertension study. J Hypertens, 2002, 20: 1879-1886.Lindholm LH, Ibsen H, Borch-Johnsen K, et al, LIFE study group. Risk of new-onset diabetes in the losartan intervention for endpoint reduction in hypertension study. J Hypertens, 2002, 20: 1879-1886.Emdin CA, Anderson SG, Woodward M, Rahimi K. Usual blood pressure and risk of new-onset diabetes: evidence from 4.1 million adults and a meta-analysis of prospective studies. J Am Coll Cardiol, 2015, 66: 1552–1562 .Emdin CA, Anderson SG, Woodward M, Rahimi K. Usual blood pressure and risk of new-onset diabetes: evidence from 4.1 million adults and a meta-analysis of prospective studies. J Am Coll Cardiol, 2015, 66: 1552–1562 .Marott SCW, Nordestgaard BG, Tybjærg-Hansen A, Benn M. Components of the metabolic syndrome and risk of type 2 diabetes. J Clin Endocrinol Metab, 2016, 101: 3212–3221.Marott SCW, Nordestgaard BG, Tybjærg-Hansen A, Benn M. Components of the metabolic syndrome and risk of type 2 diabetes. J Clin Endocrinol Metab, 2016, 101: 3212–3221.Meisinger C, Döring A, Heier M. Blood pressure and risk of type 2 diabetes mellitus in men and women from the general population: the Monitoring Trends and Determinants on Cardiovascular Diseases/Cooperative Health Research in the Region of Augsburg Cohort Study. J Hypertens, 2008, 26(9): 1809-1815.Meisinger C, Döring A, Heier M. Blood pressure and risk of type 2 diabetes mellitus in men and women from the general population: the Monitoring Trends and Determinants on Cardiovascular Diseases/Cooperative Health Research in the Region of Augsburg Cohort Study. J Hypertens, 2008, 26(9): 1809-1815.Оганов Р.Г. и др. Коморбидная патология в клинической практике. Клинические рекомендации. Кардиоваскулярная терапия и профилактика, 2017, 16(6): 5–56Oganov RG, et al. Comorbid pathology in clinical practice. Clinical guidelines. Kardiovaskulyarnaya Terapiya i Profilaktika,American Diabetes Association (ADA): Screening for Type2 Diabetes. Diabetes Care, 2004, 27(Suppl 1): 11-14.American Diabetes Association (ADA): Screening for Type2 Diabetes. Diabetes Care, 2004, 27(Suppl 1): 11-14.Каминский А.В. Сахарный диабет. Часть 1. Непростые вопросы диагностики. Международный эндокринологический журнал, 2012, 3(43): 43-47Kaminsky AV. Diabetes. Part 1. Diagnostic puzzles. Mezhdunarodnyy Endokrinologicheskiy Zhurnal, 2012, 3 (43): 43-47.Tirimaccoa R, Tidemanac PA, et al. Should capillary blood glucose measurements be used in population surveys? International journal of diabetes mellitus, 2010, 2(1): 24-27.Tirimaccoa R, Tidemanac PA, et al. Should capillary blood glucose measurements be used in population surveys? International journal of diabetes mellitus, 2010, 2(1): 24-27.Приказ Минздрава России от 26 октября 2017 г. № 869н «Об утверждении порядка проведения диспансеризации определенных групп взрослого населения»Order of the Ministry of Health of Russia No. 869n «On the Approval of the Procedure for Clinical Examination of Certain Groups of Adults» of October 26, 2017.

The authors declare that there are no conflicts of interest present.