medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2018-6-61-65medsovet-2375Research ArticleБРОНХОПУЛЬМОНОЛОГИЯ. ЛОРBRONCHOPULMONOLOGY. ENTКлиническая и фармакоэкономическая оценка применения комбинации тиотропия бромида и олодатерола у пациентов с хронической обструктивной болезнью легкихClinical and economic evaluation of using fixed dose dual bronchodilator combination tiotropiumolodaterol in patients with chronic obstructive pulmonary diseaseЗыряновС. К.ZyryanovS. K.

д.м.н.

PhD

ГалатоноваЮ. А.GalatonovaY. A.Российский университет дружбы народов, Москва; Городская клиническая больница №24 Департамента здравоохранения г. МосквыРоссияRUDN University, Moscow; Municipal Clinical Hospital no. 24 of the Department of Healthcare of Moscow, MoscowRussian FederationРоссийский университет дружбы народов, МоскваРоссияRUDN University, MoscowRussian Federation201812042018066165Copyright © Зырянов С.К., Галатонова Ю.А., 20182018Зырянов С.К., Галатонова Ю.А.Zyryanov S.K., Galatonova Y.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/2375

В настоящее время существенно изменилась концепция лекарственной терапии пациентов с ХОБЛ. Исследования последних лет убедительно демонстрируют преимущества использования двойной бронхолитической терапии при определенных фенотипах ХОБЛ. Данный обзор посвящен анализу клинической и фармакоэкономической эффективности комбинации тиотропия и олодатерола (Спиолто Респимат). Применение Спиолто Респимата у пациентов с ХОБЛ приводит к улучшению спирометрических показателей, снижению одышки, а также улучшению качества жизни, связанного со здоровьем, в сравнении с плацебо, а также с монотерапией тиотропия бромидом (5 мкг) и олодатеролом (5 мкг). Согласно результатам нескольких проведенных в Европе фармакоэкономических исследований «затраты – полезность», применение препарата Спиолто Респимат по показателям полезности превосходит монотерапию тиотропия бромидом (5 мкг). Помимо этого, было выявлено, что Спиолто Респимат является доминантным в сравнении с препаратом Дуаклир Дженуэйр и комбинацией «тиотропия бромид + салметерол», а также идентичным по показателю «затраты – полезность» с препаратами Ультибро Бризхалер и Аноро Эллипта.

 

The paper is devoted to the problem of clinical efficacy and pharmacoeconomic evaluation of Spiolto Respimat. The results of clinical trials prove that Spiolto Respimat in patients with COPD improves spirometric values, symptoms of dyspnea and health-related quality of life, compared with placebo, tiotropium bromide (5 μg) and olodaterol (5 μg). According to conducted in European countries pharmacoeconomic analysis «cost-utility» therapy with Spiolto Respimat results in quality-adjusted life-year gained comparing to tiotropium bromide (5 μg). Also Spiolto Respimat is an effective option of COPD therapy comparing to the other combinations of long-acting muscarinic antagonist – long-acting beta2-adrenergic agonist.

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The authors declare that there are no conflicts of interest present.