References

medsovet

Медицинский Совет

Meditsinskiy sovet = Medical Council

2079-701X2658-5790

REMEDIUM GROUP Ltd.

10.21518/2079-701X-2018-6-96-103

medsovet-2381

Research Article

ГАСТРОЭНТЕРОЛОГИЯ

GASTROENTEROLOGY

Лечение больных эрозивным эзофагитом современный взгляд на проблему

Treatment of patients with erosive esophagitis. A modern view on the problem

Морозов

С. В.

Morozov

S. V.

к.м.н.

PhD in medicine

Кучерявый

Ю. А.

Kucheryavy

Yu. A.

к.м.н.

Кропочев

В. С.

Kropochev

V. S.

Федеральный исследовательский центр питания и биотехнологии, МоскваРоссияFederal Research Center for Nutrition and Biotechnology, MoscowRussian Federation

Московский государственный медико-стоматологический университет им. А.И. Евдокимова Минздрава РоссииРоссияYevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of RussiaRussian Federation

2018

12042018

0696103

2018

Морозов С.В., Кучерявый Ю.А., Кропочев В.С.

Morozov S.V., Kucheryavy Y.A., Kropochev V.S.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.med-sovet.pro/jour/article/view/2381

Гастроэзофагеальная рефлюксная болезнь – одно из наиболее широко встречающихся заболеваний гастроэнтерологического профиля. Выделяют несколько форм заболеваний, в том числе неэрозивную форму, эрозивный эзофагит, пищевод Барретта. В статье представлен обзор средств, использующихся для лечения эрозивной формы ГЭРБ и длительной поддерживающей терапии с позиций доказательной медицины. Основными целями лечения эрозивного эзофагита являются заживление повреждений слизистой оболочки пищевода, обеспечение длительной ремиссии заболевания, нормализация качества жизни больных. В настоящее время основой терапии эрозивного эзофагита являются ингибиторы протонной помпы (ИПП). Эти препараты используются на всех этапах лечения как для купирования симптомов, так и для заживления повреждений слизистой оболочки пищевода, а также в составе длительной поддерживающей терапии. Ввиду необходимости длительного использования ИПП закономерно возникают вопросы об их безопасности. В публикациях последних лет отмечена возможность увеличения рисков развития хронической болезни почек, инфаркта миокарда, пневмоний, развития дефицита кальция, магния, железа, витамина В12. В то же время анализ исследований, лежащих в основе наличия рисков длительного использования ИПП, выявляет ряд существенных недостатков, уменьшающих их доказательную ценность. В настоящей работе приведены данные о наиболее часто обсуждаемых рисках и их критическая оценка.

Gastroesophageal reflux disease is one of the most common diseases of the gastroenterological profile. There are several forms of illness, including non-erosive forms, erosive esophagitis, Barrett esophagus. The article provides an overview of the drugs used to treat the erosive form of GERD and long-term supportive therapy from the perspective of evidence-based medicine. The main objectives of the treatment of erosive esophagitis are to heal esophagus mucosa lesions, achieve long-term remissions, and normalize the patients’ life quality. The proton pump inhibitors (PPIs) have steadily become the mainstay in treatment of erosive esophagitis. These drugs are used at all stages of treatment, both for the relief of symptoms and healing of oesophagus mucosa lesions, and as the long-term supportive therapy. Due to the need for long-term use of IPI, their safety are open to question. The recent publications reported an increased risk of chronic kidney disease, myocardial infarction, pneumonia, calcium, magnesium, iron, vitamin B12 deficiency. At the same time, the analysis of studies underlying the risks of long-term PPI use detected some significant disadvantages that reduce their evidence-based value. This paper provides data on the most frequently discussed risks and critical assessment of them.

гастроэзофагеальная рефлюксная болезньлечениеэрозивный эзофагитингибиторы протонной помпыдекслансопразол

gastroesophageal reflux diseasetreatmenterosive esophagitisproton pump inhibitorsdexlansoprazole

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The authors declare that there are no conflicts of interest present.