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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2018-6-114-118</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-2383</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ГАСТРОЭНТЕРОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>GASTROENTEROLOGY</subject></subj-group></article-categories><title-group><article-title>Таргетная терапия воспалительных заболеваний кишечника: реалии и перспективы</article-title><trans-title-group xml:lang="en"><trans-title>Targeted therapy of inflammatory bowel diseases: realities and prospects</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маев</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Maev</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>академик РАН, д.м.н., профессор</p></bio><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Андреев</surname><given-names>Д. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Andreev</surname><given-names>D. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н.</p></bio><bio xml:lang="en"><p>PhD in medicine </p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Московский государственный медико-стоматологический университет им. А.И. Евдокимова Минздрава России<country>Россия</country></aff><aff xml:lang="en">A.I.Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of Russia<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>12</day><month>04</month><year>2018</year></pub-date><volume>0</volume><issue>6</issue><fpage>114</fpage><lpage>118</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Маев И.В., Андреев Д.Н., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Маев И.В., Андреев Д.Н.</copyright-holder><copyright-holder xml:lang="en">Maev I.V., Andreev D.N.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/2383">https://www.med-sovet.pro/jour/article/view/2383</self-uri><abstract><p>В статье систематизированы литературные данные о роли таргетной терапии в лечении пациентов с воспалительными заболеваниями кишечника. Представлены данные последних рандомизированных клинических исследований и метаанализов, анализирующих эффективность и безопасность таргетных препаратов при лечении болезни Крона и язвенного колита.</p></abstract><trans-abstract xml:lang="en"><p>This review article was designed to systematize the literature data concerning the role of targeted therapy in the treatment of patients with inflammatory bowel diseases. It presents the data of the latest randomized clinical trials and meta-analyses evaluating the efficacy and safety of targeted drugs for the treatment of Crohn’s disease and ulcerative colitis.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>воспалительные заболевания кишечника</kwd><kwd>болезнь Крона</kwd><kwd>язвенный колит</kwd><kwd>таргетная терапия</kwd><kwd>биологическая терапия</kwd><kwd>инфликсимаб</kwd><kwd>адалимумаб</kwd><kwd>голимумаб</kwd><kwd>цетролизумаб</kwd><kwd>тофациниб</kwd><kwd>филготиниб</kwd><kwd>устекинумаб</kwd><kwd>натализумаб</kwd><kwd>ведолизумаб</kwd></kwd-group><kwd-group xml:lang="en"><kwd>inflammatory bowel disease</kwd><kwd>Crohn’s disease</kwd><kwd>ulcerative colitis</kwd><kwd>targeted therapy</kwd><kwd>biological therapy</kwd><kwd>infliximab</kwd><kwd>adalimumab</kwd><kwd>golimumab</kwd><kwd>cetrolizumab</kwd><kwd>tofacinib</kwd><kwd>filgotinib</kwd><kwd>ustkinumab</kwd><kwd>natalizumab</kwd><kwd>vedolizumab</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bruining DH. 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