medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2018-6-120-126medsovet-2384Research ArticleРЕВМАТОЛОГИЯRHEUMATOLOGYЧто может претендовать на роль базисной терапии хронической боли у коморбидных больных?What can apply for the role of basic therapy for chronic pain in comorbid patients?НаумовА. В.NaumovA. V.

д.м.н., профессор

ТкачеваО. Н.TkachevaO. N.

д.м.н., профессор

Российский национальный исследовательский медицинский университет им. Н.И. Пирогова Минздрава России; Российский геронтологический научно-клинический центр, МоскваРоссияPirogov Russian National Research Medical University of the Ministry of Health of Russia, a separate structural subdivision – Russian Gerontological Research and Clinical Center, MoscowRussian Federation20181204201806120126Copyright © Наумов А.В., Ткачева О.Н., 20182018Наумов А.В., Ткачева О.Н.Naumov A.V., Tkacheva O.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/2384

Хроническая боль в суставах и спине является практически постоянным компонентом коморбидных состояний. В основе последних лежит синдром системного воспаления, активность которого влияет и на степень развития патологии, опосредующей прогрессирование хронической боли. В структуре патогенеза системного воспаления обращает на себя целый спектр транскрипционных белков, активность которых связана с уровнем синтеза провоспалительных медиаторов. Научные исследования последних лет показали, что недостаточность и дефицит витамина D3 повышают активность указанных транскрипционных белков, увеличивая прогрессирование и интенсивность компонентов коморбидности, включая болевой синдром. Фундаментальные научные исследования демонстрируют противовоспалительный и антиэрозивный эффект витамина D3в хрящевой и костной ткани.

Chronic pain in joints and back is almost constant component of the comorbidities. The comorbidities are caused by the systemic inflammation syndrome, which activity affects the degree of pathology mediating the progression of chronic pain as well. The pathogenesis pattern of systemic inflammation differs in having the whole range of transcriptional proteins, which activity is associated with the level of synthesis of pro-inflammatory mediators. Many recent studies showed that vitamin D3 deficiency and insufficiency increases the activity of these transcriptional proteins, increasing the progression and intensity of comorbidity components, including pain syndrome. Fundamental research demonstrates anti-inflammatory and anti-erosive vitamin D3 effects in cartilage and bone tissue.

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The authors declare that there are no conflicts of interest present.