medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2018-7-112-115medsovet-2417Research ArticleИНФЕКЦИИINFECTIONSКомплаентное восстановление нормоценоза влагалищаCompliance recovery of vaginal normocenosisТихомировА. Л.TikhomirovA. L.

д.м.н., профессор

MD, Prof.

МанухинИ. Б.ManukhinI. B.

д.м.н., профессор

MD, Prof.

КазенашевВ. В.KazenashevV. V.

к.м.н.

PhD in medicine

МанухинаЕ. И.ManukhinaE. I.

д.м.н., профессор

MD, Prof.

КрижановскаяА. Н.KrizhanovskayaA. N.

к.м.н.

PhD in medicine

Московский государственный медико-стоматологический университет им. А.И. ЕвдокимоваРоссияA.I.Yevdokimov Moscow State University of Medicine and DentistryRussian FederationРоддом № 8, г. МоскваРоссияMaternity Hospital No. 8, MoscowRussian Federation20181804201807112115Copyright © Тихомиров А.Л., Манухин И.Б., Казенашев В.В., Манухина Е.И., Крижановская А.Н., 20182018Тихомиров А.Л., Манухин И.Б., Казенашев В.В., Манухина Е.И., Крижановская А.Н.Tikhomirov A.L., Manukhin I.B., Kazenashev V.V., Manukhina E.I., Krizhanovskaya A.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/2417

Представлены современные данные о бактериальном вагинозе, вопросы эпидемиологии, клинических проявлений и лечения с использованием орального пробиотика.

 

The article presents the current data on bacterial vaginosis, issues of epidemiology, clinical manifestations and treatment using oral probiotic.

биоценоз влагалищабактериальный вагинозпервый пероральный пробиотикL. rhamnosus GR-1® и L. reuteri RC-14®vaginal biocenosisbacterial vaginosisfirst oral probioticL. rhamnosus GR-1® and L. reuteri RC-14®ReferencesТихомиров А.Л., Олейник Ч.Г. Бактериальный вагиноз: некоторые аспекты этиологии, патогенеза, клиники, диагностики и лечения. Гинекология, 2004, 6(2): 62–65.Tikhomirov AL, Oleinik ChG. Bacterial vaginosis: some aspects of etiology, pathogenesis, clinic, diagnosis and treatment. Gynekologiya, 2004, 6 (2): 62-65.Sobel JD. Vaginitis. N Engl J Med, 1997, 337: 1896-1903.Sobel JD. Vaginitis. N Engl J Med, 1997, 337: 1896-1903.Кира Е.Ф. Бактериальный вагиноз. М: МИА, 2012. 472 с.Кира Е.Ф. Бактериальный вагиноз. М: МИА, 2012. 472 с.Sobel JD. Vulvovaginal candidosis. Lancet, 2007, 369: 1961-1971.Sobel JD. Vulvovaginal candidosis. Lancet, 2007, 369: 1961-1971.Donders G. Diagnosis and management of bacterial vaginosis and other types of abnormal vaginal bacterial flora: review. Obstet Gynecol Surv, 2010, 65: 462-473.Donders G. Diagnosis and management of bacterial vaginosis and other types of abnormal vaginal bacterial flora: review. Obstet Gynecol Surv, 2010, 65: 462-473.Sobel JD. Bacterial vaginosis. Annu Rev Med, 2000, 51: 349-356.Sobel JD. Bacterial vaginosis. Annu Rev Med, 2000, 51: 349-356.Weir E. Bacterial vaginosis: morequestions than answers. CMAJ, 2004, 171: 448.Weir E. Bacterial vaginosis: morequestions than answers. CMAJ, 2004, 171: 448.Клинические рекомендации. Акушерство и гинекология. 4-е издание, перераб. и доп. Под ред. Г.М. Савельевой, В.Н. Серова, Г.Т. Сухих. М.: ГЭОТАР-Медиа, 2015. 1024 с.Clinical guidelines. Obstetrics and gynecology. 4th edition, revised and supplemented. Edited by Savelyeva GM, Serova VN, Sukhikh GT. M.: GEOTAR-MEDIA, 2015. 1024 p.Koumans EH, Sternberg M, Bruce C et al. The prevalence of bacterial vaginosis in the United States, 2001-2004: associations with symptoms, sexual behaviors, and reproductive health. Sex Transm Dis, 2007, 34: 864–869.Koumans EH, Sternberg M, Bruce C et al. The prevalence of bacterial vaginosis in the United States, 2001-2004: associations with symptoms, sexual behaviors, and reproductive health. Sex Transm Dis, 2007, 34: 864–869.Donders G. Diagnosis and Manadgement of bacterial vaginosis and other types of abnormal bacterial flora: a review. Obstet Gynecol Surv, 2010, 65(7): 462-473.Donders G. Diagnosis and Manadgement of bacterial vaginosis and other types of abnormal bacterial flora: a review. Obstet Gynecol Surv, 2010, 65(7): 462-473.Bautista CT, Wurapa E, Sateren WB et al. Bacterial vaginosis: a 4. synthesis of the literature on etiology, prevalence, risk factors, and relationship with chlamydia and gonorrhea infections. Mil Med Res, 2016, 3: 4.Bautista CT, Wurapa E, Sateren WB et al. Bacterial vaginosis: a 4. synthesis of the literature on etiology, prevalence, risk factors, and relationship with chlamydia and gonorrhea infections. Mil Med Res, 2016, 3: 4.Laxmi U, Agrawal S, Raghunandan C et al. Association of bacterial vaginosis with adverse fetomaternal outcome in women with spontaneous preterm labor: a prospective cohort study. J Matern Fetal Neonatal Med, 2012, 25: 64–67.Laxmi U, Agrawal S, Raghunandan C et al. Association of bacterial vaginosis with adverse fetomaternal outcome in women with spontaneous preterm labor: a prospective cohort study. J Matern Fetal Neonatal Med, 2012, 25: 64–67.Goldenberg RL, Klebanoff MA, Bacterial colonization of the vagina during pregnancy in four ethnic groups. Vaginal Infections and Prematurity Study Group. Am J Obstet Gynecol, 1996 May, 174(5): 1618-1621.Goldenberg RL, Klebanoff MA, Bacterial colonization of the vagina during pregnancy in four ethnic groups. Vaginal Infections and Prematurity Study Group. Am J Obstet Gynecol, 1996 May, 174(5): 1618-1621.Pastore LM, Royce RA et.al. Association between bacterial vaginosis and fetal fibronectin at 24-29 weeks’ gestation. Obstet Gynecol, 1999 Jan, 93(1): 117-123.Pastore LM, Royce RA et.al. Association between bacterial vaginosis and fetal fibronectin at 24-29 weeks’ gestation. Obstet Gynecol, 1999 Jan, 93(1): 117-123.Акушерство: национальное руководство. Под ред. Г.М. Савельевой, Г.Т. Сухих, В.Н. Серова, В.Е. Радзинского. 2-е изд., перераб. и доп. М.: ГЭОТАР-Медиа, 2015. 1080 с.Obstetrics: national guidelines. Edited by Savelyeva GM, Sukhykh GT, Serova VN, Radzinsky VE. 2nd edition, revised and supplemented M.: GEOTAR-MEDIA, 2015. 1080 p.Радзинский В.Е., Ордиянц И.М. Исследование БИОС: сравнительная оценка различных схем лечения бактериального вагиноза и неспецифического вульвовагинита. Status Praesens, 2013, 1(12): 52-55.Radzinsky VE, Ordiants IM. BIOS Study: comparative assessment of different treatment regimens for bacterial vaginosis and non-specific vulva vaginitis. Status Praesens, 2013, 1 (12): 52-55.Савичева А.М. и др. Сравнительное контролируемое рандомизированное исследование оценки эффективности двухэтапного лечения бактериального вагиноза. Гинекология, 2013, 15(5): 32-35.Savicheva AM, et al. A comparative, controlled, randomized study of the efficacy of a two-stage treatment for bacterial vaginosis. Gynekologiya, 2013, 15 (5): 32-35.Reid G, Bocking A. The potential for probiotics to prevent bacterial vaginosis and preterm labor. Am J Obstet Gynecol, 2003, 189: 1202–1208.Reid G, Bocking A. The potential for probiotics to prevent bacterial vaginosis and preterm labor. Am J Obstet Gynecol, 2003, 189: 1202–1208.Радзинский В.Е., Ордиянц И.М. Двухэтапная терапия вагинальных инфекций. М.: Status Praesens. 2012, 16 с.Radzinsky VE, Ordiyants IM. Two-stage therapy for vaginal infections. M.: Status Praesens. 2012, 16 p.Cianci A, Giordano R, Della A et al. Efficasy of Lactobacillus Rhamnosus GR-1 and of Lactobacillus Reuteri RC-14 in the treatment and prevention of vaginoses and bacterial vaginitis relapses. Minerva Ginecol, 2008, 60(5): 369-376.Cianci A, Giordano R, Della A et al. Efficasy of Lactobacillus Rhamnosus GR-1 and of Lactobacillus Reuteri RC-14 in the treatment and prevention of vaginoses and bacterial vaginitis relapses. Minerva Ginecol, 2008, 60(5): 369-376.Marelli G, Papaleo E, Ferrari A. Lactobacilli for prevention of urogenital infections: a review. Eur Rev Med Pharmacol Sci, 2004, 8(2): 87-95.Marelli G, Papaleo E, Ferrari A. Lactobacilli for prevention of urogenital infections: a review. Eur Rev Med Pharmacol Sci, 2004, 8(2): 87-95.Reid G et al. Oral probiotics can resolve urogenital infections. FEMS Immunol Med Microbiol, 2001, 30(1): 49-52.Reid G et al. Oral probiotics can resolve urogenital infections. FEMS Immunol Med Microbiol, 2001, 30(1): 49-52.Gardiner GE et al. Oral administration of the probiotics combination Lactobacillus Rhamnosus GR-1 and of Lactobacillus Reuteri RC-14 for human intestinal applications. International Dairy Journal, 2002, 12(2-3): 191-196.Gardiner GE et al. Oral administration of the probiotics combination Lactobacillus Rhamnosus GR-1 and of Lactobacillus Reuteri RC-14 for human intestinal applications. International Dairy Journal, 2002, 12(2-3): 191-196.Reid G et al. Oral use of Lactobacillus Rhamnosus GR-1 and of Lactobacillus Reuteri RC-14 significantly alters vaginal flora: rand-omized, placebo-controlled trial in 64 healthy women. FEMS Immunol Med Microbiol, 2003, 3(2): 131-134.Reid G et al. Oral use of Lactobacillus Rhamnosus GR-1 and of Lactobacillus Reuteri RC-14 significantly alters vaginal flora: rand-omized, placebo-controlled trial in 64 healthy women. FEMS Immunol Med Microbiol, 2003, 3(2): 131-134.Vujic G. Efficasy of oral applied probiotic capsules for bacterial vaginosis and other vaginal infections: a double-blind, randomized, placebo-controlled study Goran. Eur J Obstet Gynecol Reprod Biol, 2013, 168(10): 75-79.Vujic G. Efficasy of oral applied probiotic capsules for bacterial vaginosis and other vaginal infections: a double-blind, randomized, placebo-controlled study Goran. Eur J Obstet Gynecol Reprod Biol, 2013, 168(10): 75-79.

The authors declare that there are no conflicts of interest present.