<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2018-7-134-138</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-2420</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПРЕ- И ПОСТМЕНОПАУЗА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PRE- AND POSTMENOPAUSE</subject></subj-group></article-categories><title-group><article-title>Альтернативная терапия климактерических расстройств: эффективные пути коррекции</article-title><trans-title-group xml:lang="en"><trans-title>Alternative therapy for the treatment of menopausal disorders: effective ways to correct</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Эфендиева</surname><given-names>З. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Efendieva</surname><given-names>Z. N.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сметник</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Smetnik</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н.</p></bio><bio xml:lang="en"><p>PhD in medicine</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="en" id="aff-1"><institution>V.I. Kulakov National Medical Research Centre for Obstetrics, Gynaecology and Perinatology of the Ministry of Health of RF</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>18</day><month>04</month><year>2018</year></pub-date><volume>0</volume><issue>7</issue><fpage>134</fpage><lpage>138</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Эфендиева З.Н., Сметник А.А., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Эфендиева З.Н., Сметник А.А.</copyright-holder><copyright-holder xml:lang="en">Efendieva Z.N., Smetnik A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/2420">https://www.med-sovet.pro/jour/article/view/2420</self-uri><abstract><p>Климактерические расстройства различной степени тяжести возникают у женщин вследствие развития эстроген- дефицитного состояния в пери- и постменопаузе. Несмотря на широкий выбор лекарственных средств менопаузальной гормонотерапии (МГТ), определенное количество женщин с противопоказаниями к приему МГТ и/или гормонофобией нуждается в применении негормональных препаратов, купирующих проявления климактерического синдрома. Сбалансированное питание с восполнением дефицита витаминно-минеральных веществ играет одну из ключевых ролей в коррекции менопаузальных расстройств. Витамины повышают адаптационные возможности организма и участвуют в синтезе и метаболизме гормонов. Применение витаминно-минеральных комплексов, не имеющих побочных эффектов и противопоказаний, характерных для МГТ, является обоснованным и  эффективным методом долгосрочной негормональной терапии менопаузальных расстройств.</p><p> </p></abstract><trans-abstract xml:lang="en"><p>Menopausal disorders with varying degrees of severity occur in women due to the development of the estrogen-deficient condition in the peri- and postmenopausal period. Despite a wide range of medications for menopausal hormone therapy (MHT), a certain number of women with contraindications to MHT and/or hormone-phobia need the use of non-hormonal drugs that relieve the symptoms of menopausal syndrome. Balanced diet and replenishing vitamin and mineral deficiencies plays a key role in correcting menopausal disorders. Vitamins increase the adaptive capacity and participate in the synthesis and metabolism of hormones. The use of vitamin and mineral complexes that do not have side effects and contraindications to MHT is a valid and effective method of the long-term non-hormonal therapy for the treatment of menopausal disorders.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>менопауза</kwd><kwd>климактерический синдром</kwd><kwd>менопаузальная гормонотерапия</kwd><kwd>альтернативная терапия менопаузы</kwd><kwd>витаминно-минеральные комплексы</kwd><kwd>микронутриенты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>menopause</kwd><kwd>menopausal syndrome</kwd><kwd>menopausal hormone therapy</kwd><kwd>alternative menopause therapy</kwd><kwd>vitamin-mineral complexes</kwd><kwd>micronutrients</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Сметник В.П. Гормональная коррекция системных изменений в менопаузе М.: МИК и Агар, 2013. С. 14.</mixed-citation><mixed-citation xml:lang="en">Smetnik VP. Hormonal correction of systemic changes in menopause M.: MIC and Agar, 2013. P. 14.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Сметник В.П. и др. Менопаузальная гормонотерапия и сохранение здоровья женщин зрелого возраста. Климактерий, 2014, 4: 8.</mixed-citation><mixed-citation xml:lang="en">Smetnik VP. Menopausal hormone therapy and health preserving options for women of mature age. Klimakteriy, 2014, 4: 8.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Writing Group for the Women’s Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trial. JAMA, 2002, 288: 321–333.</mixed-citation><mixed-citation xml:lang="en">Writing Group for the Women’s Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trial. JAMA, 2002, 288: 321–333.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Paola Villa, Inbal D Amar et al. The impact of combined nutraceutical supplementation on quality of life and metabolic changes during the menopausal transition: a pilot randomized trial. Arch Gynecol Obstet, 2017, 296: 791-801.</mixed-citation><mixed-citation xml:lang="en">Paola Villa, Inbal D Amar et al. The impact of combined nutraceutical supplementation on quality of life and metabolic changes during the menopausal transition: a pilot randomized trial. Arch Gynecol Obstet, 2017, 296: 791-801.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Rossouw JE, Prentice RL, Manson JE, Wu L, Barad D, Barnabei VM, Ko M, LaCroix AZ, Margolis KL, Stefanick ML. Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause. JAMA, 2007, 297(13): 1465–1477.</mixed-citation><mixed-citation xml:lang="en">Rossouw JE, Prentice RL, Manson JE, Wu L, Barad D, Barnabei VM, Ko M, LaCroix AZ, Margolis KL, Stefanick ML. Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause. JAMA, 2007, 297(13): 1465–1477.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Ma J, Drieling R, Stafford RS. US women desire greater professional guidance on hormone and alternative therapies for menopause symptom management. Menopause, 2006, 13(3): 506–516.</mixed-citation><mixed-citation xml:lang="en">Ma J, Drieling R, Stafford RS. US women desire greater professional guidance on hormone and alternative therapies for menopause symptom management. Menopause, 2006, 13(3): 506–516.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Kathryn Ann Martin, LoAnn E. Manson. Approach to the patient with menopausal symptoms. J Clin Endocrinol Metab, 2008, 93(12): 4567-4575.</mixed-citation><mixed-citation xml:lang="en">Kathryn Ann Martin, LoAnn E. Manson. Approach to the patient with menopausal symptoms. J Clin Endocrinol Metab, 2008, 93(12): 4567-4575.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Eisenhardt S, Fleckenstein J. Traditional Chinese medicine valuably augments therapeutic options in the treatment of climacteric syndrome. Arch Gynecol Obstet, 2016, 294(1): 193–200.</mixed-citation><mixed-citation xml:lang="en">Eisenhardt S, Fleckenstein J. Traditional Chinese medicine valuably augments therapeutic options in the treatment of climacteric syndrome. Arch Gynecol Obstet, 2016, 294(1): 193–200.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Goluch-Koniuszy ZS. Nutrition of women with hair loss problem during the period of menopause. Menopause Rev, 2016, 15(1): 56-61.</mixed-citation><mixed-citation xml:lang="en">Goluch-Koniuszy ZS. Nutrition of women with hair loss problem during the period of menopause. Menopause Rev, 2016, 15(1): 56-61.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Ших Е.В., Махова А.А. Клинико- фармакологические аспекты использования в климактерический период гормоноподобных эффектов микронутриентов. Медицинский совет, 2016, 2: 44-49.</mixed-citation><mixed-citation xml:lang="en">Shih EV, Makhova AA. Clinicopharmacological aspects of using micronutrients with hormonal-like effects in the menopausal period. Meditsinsky Sovet, 2016, 2: 44-49.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Sapir-Koren R, Livshits G. Is interaction between age-dependent decline in mechanical stimulation and osteocyte-estrogen receptor levels the culprit for postmenopausalimpaired bone formation? Osteoporos Int, 2013, 24: 1771-1789.</mixed-citation><mixed-citation xml:lang="en">Sapir-Koren R, Livshits G. Is interaction between age-dependent decline in mechanical stimulation and osteocyte-estrogen receptor levels the culprit for postmenopausalimpaired bone formation? Osteoporos Int, 2013, 24: 1771-1789.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">National Institutes of Health Office of Dietary Supplements. Dietary supplement fact sheets. http://ods.od.nih.gov/Health_Information/ Information_About_Individual_Dietary_ Supplements.aspx [accessed April 19, 2010.</mixed-citation><mixed-citation xml:lang="en">National Institutes of Health Office of Dietary Supplements. Dietary supplement fact sheets. http://ods.od.nih.gov/Health_Information/ Information_About_Individual_Dietary_ Supplements.aspx [accessed April 19, 2010.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Cathi Dennehy, Candy Tsourounis. A review of select vitamins and minerals used by postmenopausal women. Maturitas, 2010, 66: 370- 380.</mixed-citation><mixed-citation xml:lang="en">Cathi Dennehy, Candy Tsourounis. A review of select vitamins and minerals used by postmenopausal women. Maturitas, 2010, 66: 370- 380.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Arora R, Sharma JB, Wadhwa L et al. Эффективность препарата MENOPACE (комплекса мультивитаминов и минералов) при симптомах менопаузы: проспективные исследования с контролем плацебо. Факультет акушерства и гинекологии и биостатистики, медицинский колледж Маулана Азад и объединенный госпиталь Лок Найак, Нью-Дели.</mixed-citation><mixed-citation xml:lang="en">Arora R, Sharma JB, Wadhwa L et al. The efficacy of MENOPACE (a multivitamin and mineral complex) for the treatment of menopausal symptoms: prospective placebo control studies. Faculty of Obstetrics and Gynecology and Biostatistics, Maulana Azad Medical School, and the United Lok Nayak Hospital, New Delhi.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Кедрова А.Г., Челнакова Н.Н., Ванке Н.С. Опыт применения препарата Менопейс в комплексной послеоперационной реабилитации гинекологических больных. Институт повышения квалификации ФМБА, МЧС № 170 ФМБА России.</mixed-citation><mixed-citation xml:lang="en">Kedrova AG, Chelnakova NN, Vanke NS. Experience in using Menopace in the complex postoperative rehabilitation of gynecological patients. Advanced Training Institute of FMBA, Emergencies Department No. 170, FMBA of Russia.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Кедрова А.Г., Челнакова Н.Н., Ванке Н.С. Витаминно-минеральный комплекс Менопейс в лечении гинекологических больных пре- и менопаузального возраста. РМЖ, 2014, 1: 71-74.</mixed-citation><mixed-citation xml:lang="en">Kedrova AG, Chelnakova NN, Vanke NS. Vitamin-mineral complex Menopace for the treatment of gynecological patients of pre- and menopausal age. RMJ, 2014, 1: 71-74.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
