medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2018-3-18-21medsovet-2448Research ArticleЗАБОЛЕВАНИЯ ПИЩЕВОДА И ЖЕЛУДКАESOPHAGEAL AND GASTRIC DISEASESЗначение адекватной кислотосупрессии в рамках терапии helicobacter pylori-ассоциированных заболеванийSignificance of adequate acid suppression as part of helicobacter pylori-associated disease therapyАндреевД. Н.AndreevD. N.

к.м.н.

PhD in medicine

ВелиевА. М.VelievA. M.Московский государственный медико-стоматологический университет им. А.И. Евдокимова Минздрава РоссииРоссияYevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of RussiaRussian Federation201819042018031821Copyright © Андреев Д.Н., Велиев А.М., 20182018Андреев Д.Н., Велиев А.М.Andreev D.N., Veliev A.M.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/2448

В статье систематизированы литературные данные о роли адекватной кислотосупрессии в рамках терапии Helicobacter pylori-ассоциированных заболеваний. Повышение уровня рН в желудке коррелирует с эффективностью проводимой эрадикационной терапии. Так, при более высоких значениях рН снижаются минимальные ингибирующие концентрации амоксициллина, кларитромицина и метронидазола, увеличивая чувствительность Helicobacter pylori к этим антибактериальным препаратам. Помимо этого, увеличение рН в желудке способствует повышению устойчивости ряда антибактериальных средств, что повышает вероятность успешной эрадикации микроорганизма.

 

The article presents a systematized review of the literature data on the role of adequate acid suppression in the treatment of Helicobacter pylori-associated diseases. The increased pH levels in the stomach correlate with the efficacy of eradication therapy. Thus, minimal inhibitory concentrations of amoxicillin, clarithromycin and metronidazole decrease at higher pH levels, increasing the Helicobacter pylori sensitivity to these antibacterial drugs. In addition, the increased pH levels in the stomach contribute to the stability of some antibacterial agents, which increases the likelihood of eradication success.

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The authors declare that there are no conflicts of interest present.