medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2018-3-54-59medsovet-2454Research ArticleЗАБОЛЕВАНИЯ ПЕЧЕНИLIVER DISEASEЭффективность урсодезоксихолевой кислоты в лечении неалкогольной жировой болезни печениEfficacy of ursodezoxycolic acid in the treatment of non-alcoholic fatty liver diseaseДичеваД. Т.DichevaD. T.

к.м.н.

PhD in medicine

КузнецоваЕ. И.KuznetsovaE. I.БаеваТ. А.BaevaT. A.Московский государственный медико-стоматологический университет им. А.И. ЕвдокимоваРоссияYevdokimov Moscow State University of Medicine and DentistryRussian FederationГлавный клинический госпиталь МВД России, МоскваРоссияCentral Clinical Hospital of Ministry of Internal Affairs of RussiaRussian Federation201819042018035459Copyright © Дичева Д.Т., Кузнецова Е.И., Баева Т.А., 20182018Дичева Д.Т., Кузнецова Е.И., Баева Т.А.Dicheva D.T., Kuznetsova E.I., Baeva T.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/2454

Неалкогольная жировая болезнь печени (НАЖБП) по распространенности постепенно становится ведущей патологией печени в мире. Экспертными группами как в США, странах Западной Европы, так и в РФ в рамках лечения НАЖБП во главу угла ставится модификация образа жизни, включающая оптимизацию физических нагрузок, диетотерапию и, как следствие, снижение ИМТ. Однако для практикующего врача часто представляется затруднительным убедить пациента в необходимости изменить свой образ жизни и характер питания. В силу этого чрезвычайно важным представляется медикаментозная коррекция, направленная на снижение массы тела, редукцию инсулинорезистентности и уменьшение тяжести повреждения паренхимы печени. К настоящему времени в клинической практике при лечении НАЖБП высокую эффективность продемонстрировали препараты урсодезоксихолевой кислоты (Урсосан), воздействующие на несколько патогенетических механизмов данного заболевания.

Non-alcoholic fatty liver disease (NAFLD) becomes gradually the most frequent liver disease in the world. Expert teams in the USA, Western Europe, and Russia give pride of place within the NAFLD treatment regime to lifestyle modification including the optimization of physical activity, diet and, as a consequence, the BMI reduction. However, it is often difficult for the practitioner to motivate the patients to change their lifestyle and eating habits. Due to this, it is extremely important to use a pharmacologic therapy aimed at weight loss, reducing insulin resistance and repopulating the severely damaged liver parenchyma. By now ursodeoxycholic acid drugs (Ursosan) have been proved to be highly effective in treating NAFLD in clinical practice, having a significant impact on several pathogenetic mechanisms of this disease.

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The authors declare that there are no conflicts of interest present.