medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2018-3-86-89medsovet-2459Research ArticleПрактикаPracticeОценка эффективности и безопасности применения ребамипида в схеме тройной эрадикационной терапии инфекции Helicobacter pylori пилотное исследованиеEvaluation of efficacy and safety of rebamipide use in the triple therapy for Helicobacter pylori eradication: a pilot studyДичеваД. Т.DichevaD. T.

к.м.н.

PhD in medicine

АндреевД. Н.AndreevD. N.

к.м.н.

PhD in medicine

Парцваниа-ВиноградоваЕ. В.Partsvania-VinogradovaI. V.МаевИ. В.MaevI. V.

акад. РАН, д.м.н., профессор

Acad. of RAS, MD, Prof.

Московский государственный медико-стоматологический университет им. А.И. Евдокимова Минздрава РоссииРоссияYevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of RussiaRussian Federation201820042018038689Copyright © Дичева Д.Т., Андреев Д.Н., Парцваниа-Виноградова Е.В., Маев И.В., 20182018Дичева Д.Т., Андреев Д.Н., Парцваниа-Виноградова Е.В., Маев И.В.Dicheva D.T., Andreev D.N., Partsvania-Vinogradova I.V., Maev I.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/2459

В статье приводятся результаты пилотного проспективного рандомизированного исследования, целью которого явилась оценка эффективности и безопасности применения ребамипида (Ребагит, PRO.MED.CS Praha a.s., Чехия) в составе схемы тройной эрадикационной терапии инфекции Helicobacter pylori (H. pylori). В исследование было включено 54 пациента с H. pylori-ассоциированной язвенной болезнью желудка/двенадцатиперстной кишки. В процессе рандомизации было сформировано 2 группы в зависимости от получаемой схемы эрадикационной терапии: первая группа – классическая тройная схема, вторая группа – классическая тройная схема с включением ребамипида. Эффективность эрадикации H. pylori в первой группе составила 78,2% (ITT), 81,8% (PP), а у пациентов второй группы – 83,8% (ITT), 86,6% (PP). Отношение шансов эффективной эрадикации при применении ребамипида в составе классической тройной схемы эрадикационной терапии составило 1,44 (95 ДИ: 0,36–5,72). Частота побочных явлений между группами оказалась сопоставимой.

The article presents the results of a pilot prospective randomized study aimed at evaluating the efficacy and safety of rebamipide (Rebagit, PRO.MED.CS Praha a.s., Czech Republic) as part of the triple therapy for helicobacter pylori (H. Pylori) eradication. 54 patients with H. pylori-associated gastric ulcer/duodenal ulcer were enrolled to the study. All patients were randomized to two therapeutic groups depending on the eradication therapy to be received. Group 1 received the standard triple therapy, Group 2 received the standard triple therapy plus rebamipide. The efficacy of H. pylori eradication in Group 1 amounted to 78,2% (ITT), 81,8% (PP), and in Group 2 to 83,8% (ITT), 86,6% (PP). Odd ratio of efficient eradication with the use of rebamipide as part of standard triple therapy for helicobacter pylori eradication was 1,44 (95 CI: 0,36–5,72). The side effect rates between the groups were comparable

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The authors declare that there are no conflicts of interest present.