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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2018-9-46-49</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-2475</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ДЕМИЕЛИНИЗИРУЮЩИЕ ЗАБОЛЕВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>DEMYELINATING DISEASES</subject></subj-group></article-categories><title-group><article-title>Алгоритм лечения больного ремитирующим рассеянным склерозом с субоптимальным ответом на примере клинического случая</article-title><trans-title-group xml:lang="en"><trans-title>The algorithm of treatment of the patient with relapsing-remitting multiple sclerosis with suboptimal response:the example of a clinical case</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Попова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Popova</surname><given-names>E. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Брюхов</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bryukhov</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бойко</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Boyko</surname><given-names>A. N.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кротенкова</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Krotenkova</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУЗ Городская клиническая больница №24 Департамента здравоохранения г. Москвы; ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Interregional Department of Multiple Sclerosis at Moscow Clinical Hospital №24; Pirogov Russian National Research Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБНУ Научный центр неврологии</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Center of Neurology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>29</day><month>05</month><year>2018</year></pub-date><volume>0</volume><issue>9</issue><fpage>46</fpage><lpage>49</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Попова Е.В., Брюхов В.В., Бойко А.Н., Кротенкова М.В., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Попова Е.В., Брюхов В.В., Бойко А.Н., Кротенкова М.В.</copyright-holder><copyright-holder xml:lang="en">Popova E.V., Bryukhov V.V., Boyko A.N., Krotenkova M.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/2475">https://www.med-sovet.pro/jour/article/view/2475</self-uri><abstract><p>В данной статье представлен клинический случай субоптимального ответа на терапию рассеянного склероза и алгоритм ведения с учетом имеющихся критериев эффективности.</p></abstract><trans-abstract xml:lang="en"><p>This article presents a clinical case of suboptimal response to multiple sclerosis therapy and an algorithm for treatment, taking into account the existing performance criteria.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>рассеянный склероз</kwd><kwd>диметилфумарат</kwd><kwd>субоптимальный ответ</kwd></kwd-group><kwd-group xml:lang="en"><kwd>multiple sclerosis</kwd><kwd>dimethylfumarate</kwd><kwd>suboptimal response</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Lublin FD et al. Defining the clinical course of multiple sclerosis, The 2013 revisions. Neurology, 2014 Jul 15,). 83(3): 278–286. doi:10.1212/WNL.0000000000000560.</mixed-citation><mixed-citation xml:lang="en">Lublin FD et al. Defining the clinical course of multiple sclerosis, The 2013 revisions. Neurology, 2014 Jul 15,). 83(3): 278–286. doi:10.1212/WNL.0000000000000560.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Freedman M, Rush C Severe, Highly Active, or Aggressive Multiple Sclerosis. CONTINUUM: Lifelong Learning in Neurology, 2016, 22: 761784. doi: 10.1212/con.0000000000000331.</mixed-citation><mixed-citation xml:lang="en">Freedman M, Rush C Severe, Highly Active, or Aggressive Multiple Sclerosis. CONTINUUM: Lifelong Learning in Neurology, 2016, 22: 761784. doi: 10.1212/con.0000000000000331.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Polman CH, Reingold SC, Banwell B, Clanet M, Cohen JA, Filippi M, Fujihara K, Havrdova E, Hutchinson M, Kappos L, Lublin FD, Montalban X, O’Connor P, Sandberg-Wollheim M, Thompson AJ, Waubant E, Weinshenker B, Wolinsky JS. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Annals of neurology, 69(2): 292-302. doi:10.1002/ana.22366.</mixed-citation><mixed-citation xml:lang="en">Polman CH, Reingold SC, Banwell B, Clanet M, Cohen JA, Filippi M, Fujihara K, Havrdova E, Hutchinson M, Kappos L, Lublin FD, Montalban X, O’Connor P, Sandberg-Wollheim M, Thompson AJ, Waubant E, Weinshenker B, Wolinsky JS. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Annals of neurology, 69(2): 292-302. doi:10.1002/ana.22366.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Алифирова В.М., Бойко А.Н., Власов Я.В. [и др.]. Клинические рекомендации по применению препарата диметилфумарат при ремитирующе-рецидивирующем рассеянном склерозе. Журн. неврол и психиатр, 2017, 1: 97-102. doi: 10/17116/jnevro20171171197-102.</mixed-citation><mixed-citation xml:lang="en">Alifirova VM, Boyko AN, Vlasov YaV, et al. Clinical guidelines for use of dimethyl fumarate in remitting-relapsing multiple sclerosis. Zhurn. Nevrol i Psikhiatr, 2017, 1: 97-102. doi: 10/17116/jnevro20171171197-102</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Moharregh-Khiabani D, Linker R, Gold R, Stangel M. Fumaric Acid and its Esters: An Emerging Treatment for Multiple Sclerosis. Current Neuropharmacology, 2009, 7(1): 60-64. doi:10.2174/157015909787602788.</mixed-citation><mixed-citation xml:lang="en">Moharregh-Khiabani D, Linker R, Gold R, Stangel M. Fumaric Acid and its Esters: An Emerging Treatment for Multiple Sclerosis. Current Neuropharmacology, 2009, 7(1): 60-64. doi:10.2174/157015909787602788.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Sormani MP, Rio J, Tintore M, Signori A, Li D, Cornelisse P. Scoring treatment response in patients with relapsing multiplesclerosis. Mult Scler, 2013, 19: 605-612. doi:10.1177/1352458512460605.</mixed-citation><mixed-citation xml:lang="en">Sormani MP, Rio J, Tintore M, Signori A, Li D, Cornelisse P. Scoring treatment response in patients with relapsing multiplesclerosis. Mult Scler, 2013, 19: 605-612. doi:10.1177/1352458512460605.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Freedman MS, Selchen D, Arnold DL, Prat A, Banwell B, Yeung M, et al. Treatment optimization in MS: Canadian MS Working Group updated recommendations. Can J NeurolSci, 2013, 40: 307-323. doi: 10.1017/S0317167100014244.</mixed-citation><mixed-citation xml:lang="en">Freedman MS, Selchen D, Arnold DL, Prat A, Banwell B, Yeung M, et al. Treatment optimization in MS: Canadian MS Working Group updated recommendations. Can J NeurolSci, 2013, 40: 307-323. doi: 10.1017/S0317167100014244.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Критерии неэффективности терапии и отмены ПИТРС первой линии и замены на препараты второй линии. Журнал неврологии и психиатрии им. С.С. Корсакова, Приложение, 2015, 115(8): 44-44. doi: 10.17116/jnevro20151158244.</mixed-citation><mixed-citation xml:lang="en">Criteria for ineffectiveness of therapy and cancellation of multiple sclerosis disease modifying drugs of the first line and replacement them for second-line therapy. Zhurnal Nevrologii i Psikhiatrii Im. S.S. Korsakova. Prilozheniye, 2015, 115 (8): 44-44. doi: 10.17116/jnevro20151158244.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Inc. M. Longer-term follow-up of the efficacy of delayed-release dimethyl fumarate in newly diagnosed patients with RRMS: an integrated analysis of DEFINE, CONFIRM, and ENDORSE. Onlinelibraryectrims-congresseu. 2016. Available at: http://onlinelibrary.ectrims-congress.eu/ectrims/2015/31st/115560/. Accessed April 24, 2016.</mixed-citation><mixed-citation xml:lang="en">Inc. M. Longer-term follow-up of the efficacy of delayed-release dimethyl fumarate in newly diagnosed patients with RRMS: an integrated analysis of DEFINE, CONFIRM, and ENDORSE. Onlinelibraryectrims-congresseu. 2016. Available at: http://onlinelibrary.ectrims-congress.eu/ectrims/2015/31st/115560/. Accessed April 24, 2016.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Viglietta V, Miller D, Bar-Or A et al. Efficacy of delayed-release dimethyl fumarate in relapsing-remitting multiple sclerosis: integrated analysis of the phase 3 trials. Annals of Clinical and Translational Neurology, 2014, 2(2): 103118. doi:10.1002/acn3.148.</mixed-citation><mixed-citation xml:lang="en">Viglietta V, Miller D, Bar-Or A et al. Efficacy of delayed-release dimethyl fumarate in relapsing-remitting multiple sclerosis: integrated analysis of the phase 3 trials. Annals of Clinical and Translational Neurology, 2014, 2(2): 103118. doi:10.1002/acn3.148.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
