<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2018-9-62-67</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-2478</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>РЕВМАТОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>RHEUMATOLOGY</subject></subj-group></article-categories><title-group><article-title>Лечение остеопoроза у пациентов, перенесших низкоэнергетические переломы вопросы диагностики и приверженности патогенетическому лечению</article-title><trans-title-group xml:lang="en"><trans-title>Treatment of osteoporosis in patients who had low-energy fractures: challenges of diagnosis and commitment to pathogenetic treatment</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Добровольская</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dobrovolskaya</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Демин</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Demin</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Феклистов</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Feklistov</surname><given-names>A. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Торопцова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Toroptsova</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное агентство научных организаций России, ФГБНУ Научно-исследовательский институт ревматологии им. В.А. Насоновой</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Agency for Research Organizations of Russia, V.A.Nasonova Research Institute of Rheumatology, FGBNU</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>30</day><month>05</month><year>2018</year></pub-date><volume>0</volume><issue>9</issue><fpage>62</fpage><lpage>67</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Добровольская О.В., Демин Н.В., Феклистов А.Ю., Торопцова Н.В., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Добровольская О.В., Демин Н.В., Феклистов А.Ю., Торопцова Н.В.</copyright-holder><copyright-holder xml:lang="en">Dobrovolskaya O.V., Demin N.V., Feklistov A.Y., Toroptsova N.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/2478">https://www.med-sovet.pro/jour/article/view/2478</self-uri><abstract><p>Остеопороз и его осложнения (низкоэнергетические переломы) являются одной из значимых проблем в здравоохранении многих развитых стран. Социально-экономические затраты, направленные на профилактику и лечение данного заболевания, увеличиваются с каждым годом в связи с ростом продолжительности жизни населения. В России для лечения остеопороза применяются практически все препараты с противопереломным действием, которые используются в мире. Однако частота переломов в популяции снижается недостаточно, что связано не столько с неэффективностью лечения, сколько с низкой приверженностью ему. В статье представлены данные наблюдательного исследования 154 пациентов (4 мужчины и 150 женщин, средний возраст 65±7 лет), перенесших остеопоротические переломы четырех основных локализаций. Прием патогенетических препаратов начали лишь 36% опрошенных лиц. Достоверно чаще лечение получали больные с ревматическими заболеваниями, которые наблюдались у ревматолога. При анализе причин отсутствия патогенетической терапии остео пороза оказалось, что в 36% случаев не было рекомендаций травматолога, а также терапевта или врача общей практики, наблюдавших пациентов после перелома. Риск повторных переломов по FRAX® не был оценен ни у одного пациента, а направление на денситометрическое обследование получили лишь 12% человек. Консультация в специализированном Центре остеопороза позволила увеличить долю лиц, начавших принимать противоостеопоротическую терапию, почти в два раза.</p></abstract><trans-abstract xml:lang="en"><p>Osteoporosis and its complications (low-energy fractures) are one of the significant health problems in many developed countries. Socio-economic costs aimed at the prevention and treatment of this disease are increasing every year due to the increased life expectancy of the population. Almost all drugs with an anti-fracture effect for the treatment of osteoporosis, which are used in the world,   are used in Russia. However, the incidence of fractures in the population is reduced insufficiently, which is due to not so much ineffective treatment as to low adherence to it. The article presents data of the observational study of 154 patients (4 men and 150 women, mean age 65 ± 7 years), who had osteoporotic fractures of four main localizations. Only 36% of the questioned persons started taking pathogenetic drugs. Patients with rheumatic diseases, which were followed up by a rheumatologist, received treatment statistically more often.  When analysing the reasons for the absence of pathogenetic therapy for osteoporosis, it turned out that no recommendations of a traumatologist, a therapist or general practitioner, who followed up patients after a fracture, were provided in 36% of cases.  Not a single patient had their repeated fracture risk estimated using FRAX probabilities, and only 12% of people were referred to densitometric examination. After consultation in a specialized osteoporosis center, the proportion of people who started taking anti-osteoporotic therapy increased almost 2 times.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>остеопороз</kwd><kwd>приверженность лечению</kwd><kwd>бисфосфонаты</kwd><kwd>алендронат</kwd></kwd-group><kwd-group xml:lang="en"><kwd>osteoporosis</kwd><kwd>adherence to treatment</kwd><kwd>bisphosphonates</kwd><kwd>alendronate</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Kanis JA, McCloskey EV, Johansson H, Cooper C, Rizzoli R, Reginster JY. European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int, 2013, 24(1): 23-57. doi: 10.1007/s00198-0122074-y.</mixed-citation><mixed-citation xml:lang="en">Kanis JA, McCloskey EV, Johansson H, Cooper C, Rizzoli R, Reginster JY. European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int, 2013, 24(1): 23-57. doi: 10.1007/s00198-0122074-y.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Лесняк О.М., Ершова О.Б., Белова К.Ю., Гладкова Е.Н., Синицына О.С., Ганерт О.А. и др. Эпидемиология остеопоротических переломов в Российской Федерации и российская модель FRAX®. Остеопороз и остеопатии, 2014, 3: 3-8.</mixed-citation><mixed-citation xml:lang="en">Lesnyak OM, Ershova OB, Belova KYu., Gladkova EN, Sinitsyna OS, Ganert OA. Epidemiology of osteoporotic fractures in the Russian Federation and the Russian FRAX® model. Osteoporoz i Osteopatii, 2014, 3: 3-8.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Hernlund E, Svedbom A, Ivergård M, Compston J, Cooper C, Stenmark J, et al. Osteoporosis in the European Union: medical management, epidemiology and economic burden. A report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA). Arch Osteoporos, 2013, 8: 136. doi: 10.1007/s11657-013-0136-1.</mixed-citation><mixed-citation xml:lang="en">Hernlund E, Svedbom A, Ivergård M, Compston J, Cooper C, Stenmark J, et al. Osteoporosis in the European Union: medical management, epidemiology and economic burden. A report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA). Arch Osteoporos, 2013, 8: 136. doi: 10.1007/s11657-013-0136-1.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Бахтиярова СА. Проспективное исследование качества жизни и социально-экономических последствий осложненного остеопороза. Автореф. дисс….канд. мед. наук. М., 2009, 24 с.</mixed-citation><mixed-citation xml:lang="en">Bakhtiyarova SA. Prospective study of thequality of life and socio-economic consequences of complicated osteoporosis. Extended abstract of dissertation of PhD in medicine. Moscow, 2009, 24 p.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Добровольская О.В., Никитинская О.А., Торопцова Н.В. Остеопороз и его осложнения: приверженность лечению и возможности ее повышения. Современная ревматология, 2011, 5(3): 30-33. doi: 10.14412/1996-7012-2011681.</mixed-citation><mixed-citation xml:lang="en">Dobrovolskaya OV, Nikitinskaya OA, Toroptsova NV. Osteoporosis and its complications: adherence to treatment and prospects for its improvement. Sovremennaya Revmatologiya, 2011, 5 (3): 30-33. doi: 10.14412/1996-7012-2011-681.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Баранова И.А., Белая Ж.Е., Гассер Р.В., Гриффит Д.Ф., Дженант Г.К., Дорофейков В.В. и др. Остеопороз: руководство для врачей. М., 2016. 464 с.</mixed-citation><mixed-citation xml:lang="en">Baranova IA, Belaya ZhE., Gasser RV, Griffith DF, Jentant GK, Dorofeykov VV, et al. Osteoporosis: a guide for doctors. Moscow, 2016. 464 p.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Siris ES, Selby PL, Saag KG, Borgström F, Herings RM, Silverman SL. Impact of osteoporosis treatment adherence on fracture rates in North America and Europe. Am J Med, 2009, 122(2 Suppl): S3-13. doi: 10.1016/j. amjmed.2008.12.002.</mixed-citation><mixed-citation xml:lang="en">Siris ES, Selby PL, Saag KG, Borgström F, Herings RM, Silverman SL. Impact of osteoporosis treatment adherence on fracture rates in North America and Europe. Am J Med, 2009, 122(2 Suppl): S3-13. doi: 10.1016/j. amjmed.2008.12.002.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Siris ES, Harris ST, Rosen CJ, Barr CE, Arvesen JN, Abbott TA, Silverman S. Adherence to bisphosphonate therapy and fracture rates in osteoporotic women: relationship to vertebral and nonvertebral fractures from 2 US claims databases. Mayo Clin Proc, 2006 Aug, 81(8): 1013-22. doi: 10.4065/81.8.1013.</mixed-citation><mixed-citation xml:lang="en">Siris ES, Harris ST, Rosen CJ, Barr CE, Arvesen JN, Abbott TA, Silverman S. Adherence to bisphosphonate therapy and fracture rates in osteoporotic women: relationship to vertebral and nonvertebral fractures from 2 US claims databases. Mayo Clin Proc, 2006 Aug, 81(8): 1013-22. doi: 10.4065/81.8.1013.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Gallagher AM, Rietbrock S, Olson M, van Staa TP. Fracture outcomes related to persistence and compliance with oral bisphosphonates. J Bone Miner Res, 2008 Oct, 23(10): 1569-75. doi: 10.1359/jbmr.080510.</mixed-citation><mixed-citation xml:lang="en">Gallagher AM, Rietbrock S, Olson M, van Staa TP. Fracture outcomes related to persistence and compliance with oral bisphosphonates. J Bone Miner Res, 2008 Oct, 23(10): 1569-75. doi: 10.1359/jbmr.080510.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Yood RA, Emani S, Reed JI, Lewis BE, Charpentier M, Lydick E, et al. Compliance with pharmacologic therapy for osteoporosis. Osteoporos Int, 2003 Dec, 14(12): 965-8. doi: 10.1007/s00198-003-1502-4.</mixed-citation><mixed-citation xml:lang="en">Yood RA, Emani S, Reed JI, Lewis BE, Charpentier M, Lydick E, et al. Compliance with pharmacologic therapy for osteoporosis. Osteoporos Int, 2003 Dec, 14(12): 965-8. doi: 10.1007/s00198-003-1502-4.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">McCombs JS, Thiebaud P, McLaughlin-Miley C, Shi J. Compliance with drug therapies for the treatment and prevention of osteoporosis. Maturitas, 2004 Jul 15, 48(3): 271-87. doi: 10.1016/j.maturitas.2004.02.005.</mixed-citation><mixed-citation xml:lang="en">McCombs JS, Thiebaud P, McLaughlin-Miley C, Shi J. Compliance with drug therapies for the treatment and prevention of osteoporosis. Maturitas, 2004 Jul 15, 48(3): 271-87. doi: 10.1016/j.maturitas.2004.02.005.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Торопцова Н.В., Добровольская О.В. Проспективное исследование качества жизни больных остеопорозом после переломов различной локализации. Справочник врача общей практики, 2016, 7: 27-37.</mixed-citation><mixed-citation xml:lang="en">Toroptsova NV, Dobrovolskaya OV. Prospective study of the quality of life of patients with osteoporosis after fractures of different localization. Spravochnik Vracha Obshhey Praktiki, 2016, 7: 27-37.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Баранова И.А., Торопцова Н.В., Лесняк О.М. Основные положения клинических рекомендаций «Диагностика, профилактика и лечение глюкокортикоидного остеопороза у мужчин и женщин 18 лет и старше». Остеопороз и остеопатии, 2014, 3: 34-7.</mixed-citation><mixed-citation xml:lang="en">Baranova IA, Toroptsova NV, Lesnyak OM. The main provisions of the clinical guidelines for diagnosis, prevention and treatment of glucocorticoid osteoporosis in men and women of 18 years and older. Osteoporoz i Osteopatii, 2014, 3: 34-7.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Modi A, Sen S, Adachi JD, Adami S, Cortet B, Cooper AL, Geusens P, Mellström D, Weaver J, van den Bergh J P, Nguyen AM, Sajjan S, MUSICOS Study Group. Gastrointestinal symptoms and association with medication use patterns, adherence, treatment satisfaction, quality of life, and resource use in osteoporosis: baseline results of the MUSIC-OS study. Osteoporos Int, 2016, 27: 1227-1238. doi: 10.1007/s00198-0153388-3.</mixed-citation><mixed-citation xml:lang="en">Modi A, Sen S, Adachi JD, Adami S, Cortet B, Cooper AL, Geusens P, Mellström D, Weaver J, van den Bergh J P, Nguyen AM, Sajjan S, MUSICOS Study Group. Gastrointestinal symptoms and association with medication use patterns, adherence, treatment satisfaction, quality of life, and resource use in osteoporosis: baseline results of the MUSIC-OS study. Osteoporos Int, 2016, 27: 1227-1238. doi: 10.1007/s00198-0153388-3.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Invernizzi M, Cisari C, Carda S. The potential impact of new effervescent alendronate formulation on compliance and persistence in osteoporosis treatment. Aging Clin Exp Res, 2015, 27: 107-113. doi: 10.1007/s40520-014-0256-5.</mixed-citation><mixed-citation xml:lang="en">Invernizzi M, Cisari C, Carda S. The potential impact of new effervescent alendronate formulation on compliance and persistence in osteoporosis treatment. Aging Clin Exp Res, 2015, 27: 107-113. doi: 10.1007/s40520-014-0256-5.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Министерство здравоохранения Российской Федерации. Инструкция по применению лекарственного препарата «Биносто».</mixed-citation><mixed-citation xml:lang="en">Ministry of Health of the Russian Federation. Patient Information Leaflet for Binosto http: //www.grls.rosminzdrav.ru/Grls_View_v2. aspx?routingGuid = 0cb40ac2-8e10-49af-a7610b86a19f5449&amp;t= c056dcb6-a659-45ca-ba254b0d7033eaac.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Albert SG, Reddy S. Clinical Evaluation of Cost Efficacy of Drugs for Treatment of Osteoporosis. A Meta-analysis. Endocr Pract, 2017, 23(7): 841856. doi: 10.4158/EP161678.RA.</mixed-citation><mixed-citation xml:lang="en">Albert SG, Reddy S. Clinical Evaluation of Cost Efficacy of Drugs for Treatment of Osteoporosis. A Meta-analysis. Endocr Pract, 2017, 23(7): 841856.  doi: 10.4158/EP161678.RA.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
