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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2018-11-27-30</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-2496</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НЕОНАТОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>NEONATOLOGY</subject></subj-group></article-categories><title-group><article-title>Подходы к лечению и профилактике пеленочного дерматита</article-title><trans-title-group xml:lang="en"><trans-title>Approaches to treatment and prevention of diaper dermatitis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шарова</surname><given-names>Н. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Sharova</surname><given-names>N. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>профессор кафедры дерматовенерологии педиатрического факультета</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова», Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N.I.Pirogov Russian National Research Medical University FGBOU VO, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>15</day><month>07</month><year>2018</year></pub-date><volume>0</volume><issue>11</issue><fpage>27</fpage><lpage>30</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шарова Н.М., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Шарова Н.М.</copyright-holder><copyright-holder xml:lang="en">Sharova N.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/2496">https://www.med-sovet.pro/jour/article/view/2496</self-uri><abstract><p>В статье рассматриваются особенности строения и функций кожи детей первого года жизни, причины возникновения пеленочного дерматита. Определен приоритет профилактических мер и выбор оптимального средства для местного применения, которые соответствуют международным стандартам. Подробно описаны требования к наружным средствам, применяемым у детей первого года жизни для профилактики ПД, согласно международному мнению группы экспертов.</p><p> </p></abstract><trans-abstract xml:lang="en"><p>The article deals with the features of skin structure and functions in infants and the causes of diaper dermatitis. It determined the priority of preventive measures and the choice of optimal agents for topical application that meet international standards. The requirements for topical agents used in infants for prevention of DD are described in detail, according to the international opinion of the experts group.</p><p> </p></trans-abstract><kwd-group xml:lang="ru"><kwd>пеленочный дерматит (ПД)</kwd><kwd>кожа младенцев</kwd><kwd>наружные средства</kwd><kwd>лечение и профилактика ПД</kwd><kwd>декспантенол</kwd></kwd-group><kwd-group xml:lang="en"><kwd>diaper dermatitis (DD)</kwd><kwd>infant skin</kwd><kwd>topical agents</kwd><kwd>treatment and prevention of DD</kwd><kwd>dexapanthenol</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Nikolovski J, Stamatas GN, Kollias N, Wiegand BC. Barrier function and water-holding and transport properties of infant stratum corneum are different from adult and continue to develop through the first year of life. J Invest Dermatol, 2008, 128: 1728-1736.</mixed-citation><mixed-citation xml:lang="en">Nikolovski J, Stamatas GN, Kollias N, Wiegand BC. Barrier function and water-holding and transport properties of infant stratum corneum are different from adult and continue to develop through the first year of life. J Invest Dermatol, 2008, 128: 1728-1736.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Stamatas GN, Nikolovski J, Luedtke MA, Kollias N, Wiegand BC. Infant skin microstructure assessed in vivo differs from adult skin in organization and at the cellular level. Pediatr Dermatol, 2010, 27: 125-131.</mixed-citation><mixed-citation xml:lang="en">Stamatas GN, Nikolovski J, Luedtke MA, Kollias N, Wiegand BC. Infant skin microstructure assessed in vivo differs from adult skin in organization and at the cellular level. Pediatr Dermatol, 2010, 27: 125-131.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Hoeger PH, Enzmann CC. Skin physiology of the neonate and young infant: a prospective study of functional skin parameters during early infancy. Pediatr Dermatol, 2002, 19: 256-262.</mixed-citation><mixed-citation xml:lang="en">Hoeger PH, Enzmann CC. Skin physiology of the neonate and young infant: a prospective study of functional skin parameters during early infancy. Pediatr Dermatol, 2002, 19: 256-262.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Василевский И.В. Оптимизация ухода за кожей у новорожденных и детей грудного возраста. Международные обзоры: клиническая практика и здоровье, 2015, 1: 5-18</mixed-citation><mixed-citation xml:lang="en">Vasilevsky IV. Optimization of skin care in newborns and infants. Mezhdunarodnye Obzory: Klinicheskaja Praktika i Zdorovye, 2015, 1: 5-18.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Jordan WE, Lawson KD, Berg RW, Franxman JJ, Marrer AM. Diaper dermatitis: frequency and severity among a general infant population. Pediatr Dermatol, 1986, 3: 198-207.</mixed-citation><mixed-citation xml:lang="en">Jordan WE, Lawson KD, Berg RW, Franxman JJ, Marrer AM. Diaper dermatitis: frequency and severity among a general infant population. Pediatr Dermatol, 1986, 3: 198-207.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Мурашкин Н.Н., Материкин А.И., Епишев Р.В., Амбарчан Э.Т. Особенности течения и профилактики пеленочного дерматита у новорожденных и грудных детей. Вопросы современной педиатрии, 2015, 14(6): 710-713.</mixed-citation><mixed-citation xml:lang="en">Murashkin NN, Materikin AI, Epishev RV, Ambarchan ET. Features of the course and prevention of diaper dermatitis in newborns and infants. Voprosy Sovremennoy Pediatrii, 2015, 14 (6): 710-713.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Atherton DJ. A review of the pathophysiology, prevention and treatment of irritant diaper dermatitis. Curr Med Res Opin, 2004, 20: 645-649.</mixed-citation><mixed-citation xml:lang="en">Atherton DJ. A review of the pathophysiology, prevention and treatment of irritant diaper dermatitis. Curr Med Res Opin, 2004, 20: 645-649.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Warner RR, Stone KJ, Boissy YL. Hydration disrupts human stratum corneum ultrastructure. J Invest Dermatol, 2003, 120: 275-284.</mixed-citation><mixed-citation xml:lang="en">Warner RR, Stone KJ, Boissy YL. Hydration disrupts human stratum corneum ultrastructure. J Invest Dermatol, 2003, 120: 275-284.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Horowitz P, McLeod RP, Eichenfield LF, Fowler JF, Jr., Elias PM. Skin-cleansing and care principles for special pediatric populations. Semin Cutan Med Surg, 2013, 32: 30-32.</mixed-citation><mixed-citation xml:lang="en">Horowitz P, McLeod RP, Eichenfield LF, Fowler JF, Jr., Elias PM. Skin-cleansing and care principles for special pediatric populations. Semin Cutan Med Surg, 2013, 32: 30-32.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Stamatas GN, Tierney NK. Diaper dermatitis: etiology, manifestations, prevention, and management. Pediatr Dermatol, 2014, 31: 1-7.</mixed-citation><mixed-citation xml:lang="en">Stamatas GN, Tierney NK. Diaper dermatitis: etiology, manifestations, prevention, and management. Pediatr Dermatol, 2014, 31: 1-7.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Atherton D, Mills K. What can be done to keep babies’ skin healthy? RCM Midwives, 2004, 7: 288-290.</mixed-citation><mixed-citation xml:lang="en">Atherton D, Mills K. What can be done to keep babies’ skin healthy? RCM Midwives, 2004, 7: 288-290.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Lund C, Kuller J, Lane A, Lott JW, Raines DA. Neonatal skin care: the scientific basis for practice. J Obstet Gynecol Neonatal Nurs, 1999, 28: 241-254.</mixed-citation><mixed-citation xml:lang="en">Lund C, Kuller J, Lane A, Lott JW, Raines DA. Neonatal skin care: the scientific basis for practice. J Obstet Gynecol Neonatal Nurs, 1999, 28: 241-254.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Telofski LS, Morello AP, III, Mack Correa MC, Stamatas GN. The infant skin barrier: can we preserve, protect, and enhance the barrier? Dermatol Res Pract, 2012, 2012: 198789.</mixed-citation><mixed-citation xml:lang="en">Telofski LS, Morello AP, III, Mack Correa MC, Stamatas GN. The infant skin barrier: can we preserve, protect, and enhance the barrier? Dermatol Res Pract, 2012, 2012: 198789.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Adam R. Skin care of the diaper area. Pediatr Dermatol, 2008, 25: 427-433.</mixed-citation><mixed-citation xml:lang="en">Adam R. Skin care of the diaper area. Pediatr Dermatol, 2008, 25: 427-433.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">The European Parliament. Regulation (EC) No 1223/2009 of The European Parliament and of The Council On Cosmetic Products. 2009. 1223/2009.</mixed-citation><mixed-citation xml:lang="en">The European Parliament. Regulation (EC) No 1223/2009 of The European Parliament and of The Council On Cosmetic Products. 2009. 1223/2009.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">National Institute for Health and Care Excellence. Available at: http: //cks.nice.org.uk/ nappy-rash#!topicsummary. (Last accessed 30 January 2014).</mixed-citation><mixed-citation xml:lang="en">National Institute for Health and Care Excellence. Available at: http: //cks.nice.org.uk/ nappy-rash#!topicsummary. (Last accessed 30 January 2014).</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Atherton D, Proksch E, Schauber J, Stalder J-F. Irritfnt diaper dermatitis: best practice management. SelfCare, 2015, 6(s1): 1-11.</mixed-citation><mixed-citation xml:lang="en">Atherton D, Proksch E, Schauber J, Stalder J-F. Irritfnt diaper dermatitis: best practice management. SelfCare, 2015, 6(s1): 1-11.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Hoeger PH, Schreiner V, Klaassen IA et al. Epidermal barrier lipids in human vernix caseosa: corresponding ceramide pattern in vernix and fetal skin. Br J Dermatol, 2002, 146: 194-201.</mixed-citation><mixed-citation xml:lang="en">Hoeger PH, Schreiner V, Klaassen IA et al. Epidermal barrier lipids in human vernix caseosa: corresponding ceramide pattern in vernix and fetal skin. Br J Dermatol, 2002, 146: 194-201.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Proksch E, Nissen HP. Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphateinduced irritation. J Dermatolog Treat, 2002, 13: 173-178.</mixed-citation><mixed-citation xml:lang="en">Proksch E, Nissen HP. Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphateinduced irritation. J Dermatolog Treat, 2002, 13: 173-178.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Одинаева Н.Д., Беляева И.А., Яцык Г.В. Профилактические и лечебные средства для ухода за кожей недоношенных детей. Педиатрическая фармакология, 2009, 6(6): 118-120.</mixed-citation><mixed-citation xml:lang="en">Odinaeva ND, Belyaeva IA, Yatsyk GV. Prophylactic and therapeutic agents for skin care of premature babies. Pediatricheskaya Farmakologiya, 2009, 6 (6): 118-120.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Putet G, Guy B, Andres P et al. Effect of Bepan-then ointment in the prevention and treatment of diaper rash on premature and full-term babies. Réalités Pédiatriques, 2001, 63: 33-38.</mixed-citation><mixed-citation xml:lang="en">Putet G, Guy B, Andres P et al. Effect of Bepan-then ointment in the prevention and treatment of diaper rash on premature and full-term babies. Réalités Pédiatriques, 2001, 63: 33-38.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Prokch E, de Bony R, Trapp S, Boudon S. Topical use of dexpanthenol: a 70 th anniversary article. J Dermatolog Treat, 2017 Dec, 28(8): 766-773.</mixed-citation><mixed-citation xml:lang="en">Prokch E, de Bony R, Trapp S, Boudon S. Topical use of dexpanthenol: a 70 th anniversary article. J Dermatolog Treat, 2017 Dec, 28(8): 766-773.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Heise R, Skazik C, Marquardt Y, Czaja K et al. Dexpanthenol modulates gene expression in skin wound healing in vivo. Skin Pharmocol Physiol, 2012, 25(5): 241-8.</mixed-citation><mixed-citation xml:lang="en">Heise R, Skazik C, Marquardt Y, Czaja K et al. Dexpanthenol modulates gene expression in skin wound healing in vivo. Skin Pharmocol Physiol, 2012, 25(5): 241-8.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Wananukul S, Limpongsanuruk W, Singalavanija S, Wisuthsarewong W. Comparision of dexpanthenol and zinc oxide ointment base in the treatment of irritant diaper dermatitis from diarrhea: a multicenter stady. J Med Assoc Thai, 2006 Oct, 89(10): 1654-8.</mixed-citation><mixed-citation xml:lang="en">Wananukul S, Limpongsanuruk W, Singalavanija S, Wisuthsarewong W. Comparision of dexpanthenol and zinc oxide ointment base in the treatment of irritant diaper dermatitis from diarrhea: a multicenter stady. J Med Assoc Thai, 2006 Oct, 89(10): 1654-8.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">See AS, Salleh AB, Bakar FA et al. Risk and Health Effect of Boric Acid. American Journal of Applied Sciences, 2010, 7: 620-627.</mixed-citation><mixed-citation xml:lang="en">See AS, Salleh AB, Bakar FA et al. Risk and Health Effect of Boric Acid. American Journal of Applied Sciences, 2010, 7: 620-627.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Davies MW, Dore AJ, Perissinotto KL. Topical vitamin A, or its derivatives, for treating and preventing napkin dermatitis in infants. Cochrane Database Syst Rev, 2005, 2005: CD004300.</mixed-citation><mixed-citation xml:lang="en">Davies MW, Dore AJ, Perissinotto KL. Topical vitamin A, or its derivatives, for treating and preventing napkin dermatitis in infants. Cochrane Database Syst Rev, 2005, 2005: CD004300.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
