<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2015-9-78-83</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-250</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКУШЕРСТВО</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OBSTETRICS</subject></subj-group></article-categories><title-group><article-title>Железодефицитная анемия во время беременности - профилактика и лечение</article-title><trans-title-group xml:lang="en"><trans-title>Iron deficiency anemia during pregnancy: prevention and treatment</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Виноградова</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Vinogradova</surname></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фёдорова</surname><given-names>Т. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Fedorova</surname><given-names>T. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова Минздрава России, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Center for Obstetrics, Gynecology and Perinatology named after V.I. Kulakov, Russia’s Ministry of Health</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2015</year></pub-date><volume>0</volume><issue>9</issue><fpage>78</fpage><lpage>83</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Виноградова М.А., Фёдорова Т.А., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Виноградова М.А., Фёдорова Т.А.</copyright-holder><copyright-holder xml:lang="en">Виноградова М.А., Fedorova T.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/250">https://www.med-sovet.pro/jour/article/view/250</self-uri><abstract><p>Данный обзор посвящен проблеме профилактики и лечения анемии во время беременности. Железодефицитная анемия (ЖДА) является самым распространенным дефицитным состоянием и наиболее частой формой анемии у беременных женщин. Клинические последствия ее крайне важны, т. к. неблагоприятные эффекты железодефицита не только затрагивают организм женщины, но и способны влиять на исходы беременности и здоровье новорожденных. Первая линия терапии железодефицита - это препараты железа, предназначенные для приема внутрь, наиболее эффективной и безопасной формой которых в настоящее время считается железо-полимальтозный комплекс. При недостаточной эффективности и тяжелой форме анемии предпочтительным альтернативным методом является внутривенное введение препарата железа. Своевременная диагностика и адекватная терапия позволяют в кратчайшие сроки восстановить показатели обмена железа у беременной женщины и не допустить развития осложнений.</p></abstract><trans-abstract xml:lang="en"><p>The review is devoted to the prevention and treatment of anemia during pregnancy. Iron deficiency anemia (IDA) is the most common deficiency condition and the most widespread form of anemia in pregnant women. It has relevant clinical results, since adverse effects of iron deficiency affect not only the woman's body but may also impact the outcome of pregnancy and health of the newborn. First-line treatment of iron deficiency is oral iron preparations, among which iron polymaltose complex is regarded today as the most effective and safe treatment. In case of poor efficacy or severe anemia, the preferable alternative is intravenous iron. Early diagnosis and adequate treatment allows to quickly address iron metabolism in pregnant women and prevent development of complications.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>анемия</kwd><kwd>беременность</kwd><kwd>дефицит железа</kwd><kwd>полимальтозный комплекс гидроксида железа</kwd><kwd>anemia</kwd><kwd>pregnancy</kwd><kwd>iron deficiency</kwd><kwd>iron(III)-hydroxide polymaltose complex</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">WHO Iron Deficiency Anaemia: Assessment, Prevention and Control. WHO/NHD/01.3, World Health Organization, 2001, Geneva, Switzerland.</mixed-citation><mixed-citation xml:lang="en">WHO Iron Deficiency Anaemia: Assessment, Prevention and Control. WHO/NHD/01.3, World Health Organization, 2001, Geneva, Switzerland.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Sifakis S and Pharmakides G. Anemia in pregnancy. Ann. N. Y. Acad. Sci., 2000, 900: 125-36.</mixed-citation><mixed-citation xml:lang="en">Sifakis S and Pharmakides G. Anemia in pregnancy. Ann. N. Y. Acad. Sci., 2000, 900: 125-36.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Ramsey M, James D &amp; Steer P. Normal Values in Pregnancy, 2nd edn. WB Saunders, London, 2000.</mixed-citation><mixed-citation xml:lang="en">Ramsey M, James D &amp; Steer P. Normal Values in Pregnancy, 2nd edn. WB Saunders, London, 2000.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Coad J, Conlon C. Iron deficiency in women: assessment, causes and consequences. Current opinion in clinical nutrition and metabolic care. 2011, 14, 625-634.</mixed-citation><mixed-citation xml:lang="en">Coad J, Conlon C. Iron deficiency in women: assessment, causes and consequences. Current opinion in clinical nutrition and metabolic care. 2011, 14, 625-634.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Friedman AJ et al. Iron deficiency anemia in women across the life span. Journal of women's health, 2012, 21: 1282-1289.</mixed-citation><mixed-citation xml:lang="en">Friedman AJ et al. Iron deficiency anemia in women across the life span. Journal of women's health, 2012, 21: 1282-1289.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">The Obstetric Hematology Manual edited by Sue Pavord, Beverley Hunt. Cambridge University Press 2010. P. 13-27.</mixed-citation><mixed-citation xml:lang="en">The Obstetric Hematology Manual edited by Sue Pavord, Beverley Hunt. Cambridge University Press 2010. P. 13-27.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Ren A, Wang J, Ye RW, Li S, Liu JM, Li Z (2007). Low first trimester hemoglobin and low birth weight, preterm birth and small for gestational age new-borns. Int J Gynaecol Obstet, 98: 124-128.</mixed-citation><mixed-citation xml:lang="en">Ren A, Wang J, Ye RW, Li S, Liu JM, Li Z (2007). Low first trimester hemoglobin and low birth weight, preterm birth and small for gestational age new-borns. Int J Gynaecol Obstet, 98: 124-128.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Koller O (1982). The clinical significance of hemodilution during pregnancy. Obstet Gynecol Surv, 37:649-652.</mixed-citation><mixed-citation xml:lang="en">Koller O (1982). The clinical significance of hemodilution during pregnancy. Obstet Gynecol Surv, 37:649-652.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Breymann Ch et al. Diagnosis and treatment of iron-deficiency anaemia during pregnancy and postpartum. Arch Gynecol Obstet , 2010, 282: 577-580.</mixed-citation><mixed-citation xml:lang="en">Breymann Ch et al. Diagnosis and treatment of iron-deficiency anaemia during pregnancy and postpartum. Arch Gynecol Obstet , 2010, 282: 577-580.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Milman N (2006). Iron and pregnancy - a delicate balance. Ann Hematol, 85: 559-565.</mixed-citation><mixed-citation xml:lang="en">Milman N (2006). Iron and pregnancy - a delicate balance. Ann Hematol, 85: 559-565.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Bothwell TH (2000). Iron requirements in pregnancy and strategies to meet them. Am J Clin Nutr, 72: 257-264.</mixed-citation><mixed-citation xml:lang="en">Bothwell TH (2000). Iron requirements in pregnancy and strategies to meet them. Am J Clin Nutr, 72: 257-264.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Milman N, Byg K-E, Ovesen L (2000). Iron status in Danes updated 1994. II. Prevalence of iron deficiency and iron overload on 1319 women aged 40-70 years. Influence of blood donation, alcohol intake, and iron supplementation. Ann Hematol, 79: 612-621.</mixed-citation><mixed-citation xml:lang="en">Milman N, Byg K-E, Ovesen L (2000). Iron status in Danes updated 1994. II. Prevalence of iron deficiency and iron overload on 1319 women aged 40-70 years. Influence of blood donation, alcohol intake, and iron supplementation. Ann Hematol, 79: 612-621.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Milman N. Prepartum anaemia: prevention and treatment. Ann Hematol, 2008, 87: 949-959.</mixed-citation><mixed-citation xml:lang="en">Milman N. Prepartum anaemia: prevention and treatment. Ann Hematol, 2008, 87: 949-959.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Milman N (2006). Iron prophylaxis in pregnancy-general or individual and in which dose? Ann Hematol, 85: 821-828 doi:10.1007/ s00277-006-0145-x.</mixed-citation><mixed-citation xml:lang="en">Milman N (2006). Iron prophylaxis in pregnancy-general or individual and in which dose? Ann Hematol, 85: 821-828 doi:10.1007/ s00277-006-0145-x.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Milman N, Bergholdt T, Byg K-E, Eriksen L, Hvas A-M (2007). Reference intervals for haemato-logical variables during normal pregnancy and postpartum in 433 healthy Danish women. Eur J Haematol, 79: 39-46.</mixed-citation><mixed-citation xml:lang="en">Milman N, Bergholdt T, Byg K-E, Eriksen L, Hvas A-M (2007). Reference intervals for haemato-logical variables during normal pregnancy and postpartum in 433 healthy Danish women. Eur J Haematol, 79: 39-46.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Makrides M, Crowther CA, Gibson RA, Gibson RS, Skeaff CM (2003). Efficacy and tolerability of low-dose iron supplements during pregnancy: a randomised controlled trial. Am J Clin Nutr, 78: 145-153.</mixed-citation><mixed-citation xml:lang="en">Makrides M, Crowther CA, Gibson RA, Gibson RS, Skeaff CM (2003). Efficacy and tolerability of low-dose iron supplements during pregnancy: a randomised controlled trial. Am J Clin Nutr, 78: 145-153.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Milman N, Bergholt T, Eriksen L, Byg K-E, Graudal N, Pedersen P, Hertz J (2005). Iron prophylaxis during pregnancy - how much iron is needed? A randomised, controlled study of 20 to 80 mg ferrous iron daily to pregnant women. Acta Obstet Gynecol Scand, 84: 238-247.</mixed-citation><mixed-citation xml:lang="en">Milman N, Bergholt T, Eriksen L, Byg K-E, Graudal N, Pedersen P, Hertz J (2005). Iron prophylaxis during pregnancy - how much iron is needed? A randomised, controlled study of 20 to 80 mg ferrous iron daily to pregnant women. Acta Obstet Gynecol Scand, 84: 238-247.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Skikne B, Baynes RD (1994). Iron absorption. In: Brock JH, Halliday JW, Pippard MJ, Powell LW (eds) Iron metabolism in health and disease. Saunders, London, pp 151-187.</mixed-citation><mixed-citation xml:lang="en">Skikne B, Baynes RD (1994). Iron absorption. In: Brock JH, Halliday JW, Pippard MJ, Powell LW (eds) Iron metabolism in health and disease. Saunders, London, pp 151-187.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Milman N, Graudal N, Nielsen OJ, Agger AO (1997). Serum erythropoietin during normal pregnancy: relationship to hemoglobin and iron status markers and impact of iron supplementation in a longitudinal, placebo-controlled study on 118 women. Int J Hematol, 66: 159-168.</mixed-citation><mixed-citation xml:lang="en">Milman N, Graudal N, Nielsen OJ, Agger AO (1997). Serum erythropoietin during normal pregnancy: relationship to hemoglobin and iron status markers and impact of iron supplementation in a longitudinal, placebo-controlled study on 118 women. Int J Hematol, 66: 159-168.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Beris P, Maniatis A on behalf of the NATA working group on intravenous iron therapy (2007). Guidelines on intravenous iron supplementation in surgery and obstetrics/gynecology. TATM transfus Altern Transfus Med 9 (Suppl 1): 29.</mixed-citation><mixed-citation xml:lang="en">Beris P, Maniatis A on behalf of the NATA working group on intravenous iron therapy (2007). Guidelines on intravenous iron supplementation in surgery and obstetrics/gynecology. TATM transfus Altern Transfus Med 9 (Suppl 1): 29.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Adamson JW. Fauci AS. Kasper Dl, et al. Iron deficiency and other hypoproliferative anaemias. In: Braunwald E, editor; Harrison's Principles of Internal Medicine.15th edition. Mc Graw Hill; 2001. pp 660-66.</mixed-citation><mixed-citation xml:lang="en">Adamson JW. Fauci AS. Kasper Dl, et al. Iron deficiency and other hypoproliferative anaemias. In: Braunwald E, editor; Harrison's Principles of Internal Medicine.15th edition. Mc Graw Hill; 2001. pp 660-66.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Sharma N. Iron absorption: IPC therapy is superior to conventional iron salts. Obstet Gynecol., 2001: 515-19.</mixed-citation><mixed-citation xml:lang="en">Sharma N. Iron absorption: IPC therapy is superior to conventional iron salts. Obstet Gynecol., 2001: 515-19.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Toblli JE, Cao G, Oliveri L, Angerosa M. Effects of iron polymaltose complex, ferrous fumarate and ferrous sulfate treatments in anemic pregnant rats, their fetuses and placentas. Inflamm Allergy Drug Targets, 2013, 12(3): 190-8.</mixed-citation><mixed-citation xml:lang="en">Toblli JE, Cao G, Oliveri L, Angerosa M. Effects of iron polymaltose complex, ferrous fumarate and ferrous sulfate treatments in anemic pregnant rats, their fetuses and placentas. Inflamm Allergy Drug Targets, 2013, 12(3): 190-8.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Badhwar VR, Rao S, Fonseca MM. Comparative efficacy and safety of iron polymaltose+folic acid and oral ferrous fumarate in the treatment of adult patients with iron deficiency anemia. Indian Med Gazette, 2003, 136: 296-301.</mixed-citation><mixed-citation xml:lang="en">Badhwar VR, Rao S, Fonseca MM. Comparative efficacy and safety of iron polymaltose+folic acid and oral ferrous fumarate in the treatment of adult patients with iron deficiency anemia. Indian Med Gazette, 2003, 136: 296-301.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Patkar VD, Patkar S, Khandeparker PS, Dingankar NS, Shetty RS. Evaluation of efficacy and tolerability of iron (III) - hydroxide poly-maltose complex tablets in the treatment of iron deficiency anaemia in women. Indian Med Gazette, 2001, 135: 306-309.</mixed-citation><mixed-citation xml:lang="en">Patkar VD, Patkar S, Khandeparker PS, Dingankar NS, Shetty RS. Evaluation of efficacy and tolerability of iron (III) - hydroxide poly-maltose complex tablets in the treatment of iron deficiency anaemia in women. Indian Med Gazette, 2001, 135: 306-309.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Saha L, Pandhi P, Gopalan S, Malhotra S and Saha PK. Comparison of Efficacy, Tolerability, and Cost of Iron Polymaltose Complex With Ferrous Sulphate in the Treatment of Iron Deficiency Anemia in Pregnant Women. MedGenMed, 2007, 9(1): 1.</mixed-citation><mixed-citation xml:lang="en">Saha L, Pandhi P, Gopalan S, Malhotra S and Saha PK. Comparison of Efficacy, Tolerability, and Cost of Iron Polymaltose Complex With Ferrous Sulphate in the Treatment of Iron Deficiency Anemia in Pregnant Women. MedGenMed, 2007, 9(1): 1.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">McCord JM. Iron, free radicals, and oxidative injury. Semin Hematol., 1998, 35: 5-12.</mixed-citation><mixed-citation xml:lang="en">McCord JM. Iron, free radicals, and oxidative injury. Semin Hematol., 1998, 35: 5-12.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Christoph P, Schuller C, Studer H et al. Intravenous iron treatment in pregnancy: comparison of high-dose ferric carboxymaltose vs. iron sucrose. J Perinat Med, 2012, 13, 40(5), 469-474.</mixed-citation><mixed-citation xml:lang="en">Christoph P, Schuller C, Studer H et al. Intravenous iron treatment in pregnancy: comparison of high-dose ferric carboxymaltose vs. iron sucrose. J Perinat Med, 2012, 13, 40(5), 469-474.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Reveiz L, Gyte GML, Cuervo LG, Casasbuenas A. Treatments for iron-deficiency anaemia in pregnancy (Review), Cochrane library, 2011.</mixed-citation><mixed-citation xml:lang="en">Reveiz L, Gyte GML, Cuervo LG, Casasbuenas A. Treatments for iron-deficiency anaemia in pregnancy (Review), Cochrane library, 2011.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Beris P, Maniatis A, on behalf of the NATA working group on intravenous iron therapy (2007) Guidelines on intravenous iron supplementation in surgery and obstetrics/gynecology. TATM transfus Altern Transfus Med 9 (Suppl 1): 29.</mixed-citation><mixed-citation xml:lang="en">Beris P, Maniatis A, on behalf of the NATA working group on intravenous iron therapy (2007) Guidelines on intravenous iron supplementation in surgery and obstetrics/gynecology. TATM transfus Altern Transfus Med 9 (Suppl 1): 29.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
