medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2018-11-136-139medsovet-2515Research ArticleАЛЛЕРГОЛОГИЯ И ИММУНОЛОГИЯALLERGOLOGY AND IMMUNOLOGYАнтигистаминная терапия в педиатрической практикеAntihistamine therapy in pediatric practiceЦаревС. В.TsarevS. V.

д.м.н., ведущий научный сотрудник, поликлиническое отделение №1

ФГБУ «ГНЦ «Институт иммунологии» ФМБА России, МоскваРоссияNational Research Centre Institute of Immunology, Federal Medical-Biological Agency of Russia, MoscowRussian Federation201816072018011136139Copyright © Царев С.В., 20182018Царев С.В.Tsarev S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/2515

В статье рассмотрено участие гистамина в патогенезе аллергических заболеваний и других патологических состояний. Отдельно анализируются механизмы развития кожного зуда. Показаны место и роль блокаторов Н1-гистаминовых рецепторов в лечении аллергических заболеваний и псевдоаллергических реакций. Представлен механизм действия, показания, противопоказания и побочные эффекты антигистаминной терапии. Рассмотрены отличия антигистаминных средств первого и второго поколения. Показаны возможные преимущества препаратов первого поколения в педиатрической практике. Представлены данные о применении в детской практике диметиндена малеата (Фенистил), в т. ч. для купирования зуда кожи различного генеза.

The article considers the role of histamine in the pathogenesis of allergic diseases and other pathological conditions. The mechanisms that contribute to the development of skin itching are considered separately. The article also shows the role and function of H1-histamine receptor blockers in the treatment of allergic diseases and pseudo allergic reactions. The mechanism of action, indications, contraindications and side effects of the antihistamine therapy are presented. The article also discusses the difference in first and second-generation antihistamines and shows the possible advantages of the first-generation drugs in paediatric practice. The article presents data on the use of dimethindene maleate (Fenistil) in children’s practice, including the use for the relief of skin itching of various genesis.

антигистаминные препаратыаллергические заболеванияаллергодерматозыкожный зудФенистилantihistaminesallergic diseasesallergic dermatosesskin itchingFenistilReferencesАллергология. Фармакотерапия без ошибок. Руководство для врачей под ред. Р.М. Хаитова. М.: Е-ното, 2013, 496 с.Allergology. Pharmacotherapy without errors. A guide for practitioners under the editorship of. Khaitov RM. Moscow: E-Noto, 2013, 496 p.Федеральные клинические рекомендации по диагностике и лечению аллергического ринита. М.: РААКИ, 2013, 19 с.Federal clinical guidelines for the diagnosis and treatment of allergic rhinitis. Moscow: RAAKI, 2013, 19 p.Akdis CA, Akdis M, Bieber T, Bindslev-Jensen C, Boguniewicz M, Eigenmann P, Hamid Q et al. Diagnosis and treatment of atopic dermatitis in children andadults: European Academy of Allergology and Clinical Immunology / American Academy of Allergy, Asthma and Immunology / PRACTALL Consensus Report. Allergy, 2006, 61(8): 969-987.Akdis CA, Akdis M, Bieber T, Bindslev-Jensen C, Boguniewicz M, Eigenmann P, Hamid Q et al. Diagnosis and treatment of atopic dermatitis in children andadults: European Academy of Allergology and Clinical Immunology / American Academy of Allergy, Asthma and Immunology / PRACTALL Consensus Report. Allergy, 2006, 61(8): 969-987.Novak N, Simon D. Atopic dermatitis – from new pathophysiologic insights to individual-ized therapy. Allergy, 2011, 66(7): 830-839.Novak N, Simon D. Atopic dermatitis – from new pathophysiologic insights to individual-ized therapy. Allergy, 2011, 66(7): 830-839.Krajnik M, Zylicz Z. Understanding pruritus in systemic disease. J Pain Symptom Manage, 2001, 21: 151-68.Krajnik M, Zylicz Z. Understanding pruritus in systemic disease. J Pain Symptom Manage, 2001, 21: 151-68.Гущин И.С. Антигистаминные препараты. Посо бие для врачей. М., 2000, 55 с.Gushchin IS. Antihistamines. A guide for practitioners. M., 2000, 55 p.Du Buske LM. Clinical comparison of histamine H1-receptor antagonist drugs. J Allergy Clin. Immunol., 1996, 98: 307-318.Du Buske LM. Clinical comparison of histamine H1-receptor antagonist drugs. J Allergy Clin. Immunol., 1996, 98: 307-318.Shellow WV. Evaluation of pruritus. In: Goroll AH, Mulley AG Jr, eds. Primary care medicine: office evaluation and management of the adult patient. 4th ed. Philadelphia: Lippincott Williams & Wilkins, 2000: 1001-1004.Shellow WV. Evaluation of pruritus. In: Goroll AH, Mulley AG Jr, eds. Primary care medicine: office evaluation and management of the adult patient. 4th ed. Philadelphia: Lippincott Williams & Wilkins, 2000: 1001-1004.Krajnik M, Zylicz Z. Pruritus in advanced internal diseases: pathogenesis and treatment. Netherlands J Med, 2001, 58: 27-40.Krajnik M, Zylicz Z. Pruritus in advanced internal diseases: pathogenesis and treatment. Netherlands J Med, 2001, 58: 27-40.Delpon E, Valenzuela C, Tamargo J. Blockade of cardiac potassium and other channels by antihistamines. Drug Saf, 1999, 21(Suppl 1): 11-18, discussion 81-87: 11-18.Delpon E, Valenzuela C, Tamargo J. Blockade of cardiac potassium and other channels by antihistamines. Drug Saf, 1999, 21(Suppl 1): 11-18, discussion 81-87: 11-18.Church M. From theory to Clinical Practice: Modern Treatment of Allergic Diseases. 1st Ebastine Closed Symposium, 2002, Lisbon (Portugal).Church M. From theory to Clinical Practice: Modern Treatment of Allergic Diseases. 1st Ebastine Closed Symposium, 2002, Lisbon (Portugal).Toeroek E, Katona M. Fenistil® in the treatement of skin itching in children. Uchastkovy Pediatr 2011, 3: 9.Toeroek E, Katona M. Fenistil® in the treatement of skin itching in children. Uchastkovy Pediatr 2011, 3: 9.Englisch W, Bauer C-P. Dimethindene maleate in the treatment of pruritus caused by varicella zoster virus infection in children. Arzneimittel– Forschung, 1997, 47(11): 1233–5.Englisch W, Bauer C-P. Dimethindene maleate in the treatment of pruritus caused by varicella zoster virus infection in children. Arzneimittel– Forschung, 1997, 47(11): 1233–5.

The authors declare that there are no conflicts of interest present.