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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2018-10-9-10</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-2526</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ИММУНОТЕРАПИЯ В ОНКОЛОГИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Immunotherapy in oncology</subject></subj-group></article-categories><title-group><article-title>Клинический случай 3-летнего полного эффекта терапии пембролизумабом метастатической аденокарциномы легкого</article-title><trans-title-group xml:lang="en"><trans-title>A clinical case of 3-year highly efficient pembrolizamable therapy of metasatic lung adenocarcinoma</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лактионов</surname><given-names>К. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Laktionov</surname><given-names>K. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор медицинских наук, профессор</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Юдин</surname><given-names>Д. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Yudin</surname><given-names>D. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кандидат медицинских наук</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Саранцева</surname><given-names>К. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sarantseva</surname><given-names>K. A.</given-names></name></name-alternatives><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лактионов</surname><given-names>К. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Laktionov</surname><given-names>K. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор медицинских наук, профессор</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бредер</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Breder</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор медицинских наук</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Реутова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Reutova</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кандидат медицинских наук</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Научный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N.N. Blokhin Russian Cancer Research Centre of the Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>17</day><month>07</month><year>2018</year></pub-date><volume>0</volume><issue>10</issue><fpage>9</fpage><lpage>10</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Лактионов К.К., Юдин Д.И., Саранцева К.А., Лактионов К.П., Бредер В.В., Реутова Е.В., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Лактионов К.К., Юдин Д.И., Саранцева К.А., Лактионов К.П., Бредер В.В., Реутова Е.В.</copyright-holder><copyright-holder xml:lang="en">Laktionov K.K., Yudin D.I., Sarantseva K.A., Laktionov K.P., Breder V.V., Reutova E.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/2526">https://www.med-sovet.pro/jour/article/view/2526</self-uri><abstract><p>Иммунотерапия представляет новый перспективный подход к лечению диссеминированного рака легкого. Одним из зарегистрированных в России антиPD-1-препаратов является пембролизумаб (Китруда®), который применяется как во второй, так и – при условии высокого уровня экспрессии PD-L1 (≥50%) – первой линии терапии. В данной работе представлено клиническое наблюдение высокоэффективного лечения пембролизумабом пациента с метастатической аденокарциномой.</p></abstract><trans-abstract xml:lang="en"><p>Immunotherapy presents a new promising approach to the treatment of disseminated lung cancer. Pemriblisumab (Kitruda®) is one of the antiPD-1 drugs registered in Russia, which is used in both the secondand, in the event of high-level PD-L1 expression (≥50%), the first-line therapy. This paper presents a clinical observation of a highly efficient pemribrolizumab treatment of a patient with metastatic adenocarcinoma.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>пембролизумаб</kwd><kwd>немелкоклеточный рак легкого</kwd><kwd>PD-1</kwd><kwd>PD-L1</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pemribrolizumab</kwd><kwd>non-small cell lung cancer</kwd><kwd>PD-1</kwd><kwd>PD-L1</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Лактионов К.К., Саранцева К.А., Бредер В.В., Окружнова М.А., Перегудова М.В. Место иммуноонкологии в лечении немелкоклеточного рака легкого. Злокачественные опухоли, 2016, 3: 17-24.</mixed-citation><mixed-citation xml:lang="en">Laktionov KK, Sarantseva KA, Breder VV, Okruzhnova MA, Peregudova MV. The role of immuno-oncology in the treatment of non-small cell lung cancer. 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