medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2018-10-18-26medsovet-2528Research ArticleТАРГЕТНАЯ ТЕРАПИЯ ОПУХОЛЕЙTarget therapy of tumorsАфлиберцепт: в фокусе внимания побочные явленияAflibercept: side effects in focusФедянинМ. Ю.FedyaninM. Yu.

Доктор медицинских наук

Москва

MD

Moscow

 

ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава РоссииРоссияN.N.Blokhin National Medical Research Cancer Centre of Oncology, Federal State Budgetary Institution of the Ministry of Health of RussiaRussian Federation2018170720180101826Copyright © Федянин М.Ю., 20182018Федянин М.Ю.Fedyanin M.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/2528

В качестве второй линии терапии больных метастатическим раком толстой кишки зарегистрирован новый антиангиогенный препарат афлиберцепт, применение которого с режимом FOLFIRI значимо уменьшает риск прогрессирования болезни (ОР = 0,758, р = 0,00007). В то же время добавление афлиберцепта в исследовании VELOUR привело к развитию у 83,5% пациентов нежелательных явлений 3–4-й степени тяжести, включая не только осложнения, характерные для антиангиогенных препаратов, но и случаи диареи и нейтропении. В связи с этим онкологу необходимо разбираться в патогенезе, способах профилактики и лечения осложнений, связанных с применением афлиберцепта. Именно этим аспектам и посвящен данный обзор.

A new anti-angiogenic drug aflibercept has been authorized as a second-line therapy in patients with metastatic colon cancer. The use of this drug as part of FOLFIRI regimen significantly reduces the risk of disease progression (RR = 0.758, p = 0.00007). At the same time, the additional use of aflibercept in the VELOUR study led to the development of side effects of 3-4 degrees of severity in 83.5% of patients. In this case, the use of aflibercept in combination with FOLFIRI is not only associated with complications that are typical for anti-angiogenic drugs, but also with a high percentage of cases of diarrhea and neutropenia. In this regard, the oncologist should understand the pathogenesis, the methods for prevention and treatment of complications associated with the use of aflibercept. These particular aspects are highlighted is this review.

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The authors declare that there are no conflicts of interest present.