medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2018-10-64-69medsovet-2534Research ArticleГОРМОНОТЕРАПИЯHormonotherapyПобочные эффекты адъювантной гормонотерапииAdverse effects of adjuvant endocrine therapyКоваленкоE. И.KovalenkoE. I.

Кандидат медицинских наук

Moscow

КононенкоИ. Б.KononenkoI. B.

Кандидат медицинских наук

Moscow

СнеговойА. В.SnegovoiA. V.

Доктор медицинских наук

Moscow

ГребенниковаО. П.GrebennikovaO. P.

Кандидат медицинских наук

Moscow

МанзюкЛ. В.ManzyukL. V.

Доктор медицинских наук, профессор

Moscow

ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава РоссииРоссияN.N.Blokhin Russian Cancer Research Centre of the Ministry of Health of RussiaRussian FederationФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава РоссииРоссияA.I.Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of RussiaRussian Federation2018180720180106469Copyright © Коваленко E.И., Кононенко И.Б., Снеговой А.В., Гребенникова О.П., Манзюк Л.В., 20182018Коваленко E.И., Кононенко И.Б., Снеговой А.В., Гребенникова О.П., Манзюк Л.В.Kovalenko E.I., Kononenko I.B., Snegovoi A.V., Grebennikova O.P., Manzyuk L.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/2534

Гормонотерапия является высокоэффективным и в целом хорошо переносимым методом лечения гормонозависимого рака молочной железы. Тем не менее существует ряд побочных эффектов, которые могут снижать качество жизни пациенток и являться причиной преждевременной отмены препаратов. В статье обсуждаются основные нежелательные явления гормонотерапии: менопаузальные симптомы, гинекологические эффекты тамоксифена, сердечно-сосудистые, скелетно-мышечные осложнения. Некоторые из них могут быть предотвращены или скорректированы. Для сохранения удовлетворительного качества жизни пациенток следует больше внимания уделять побочным эффектам, действительно его снижающим, и не проявлять избыточной активности по поводу клинически незначащих проявлений.

Hormonal therapy is a highly effective and well tolerable treatment of hormone-responsive breast cancer. However, it has some side effects that can affect quality of life and lead to treatment discontinuation. Common side effects of tamoxifen and aromatase inhibitors are discussed in this article: menopausal, gynecological symptoms, cardiovascular and musculoskeletal adverse events. Some of them are preventable and manageable. In order to maintain good quality of life during treatment the oncologists should pay more attention to the side effects that lead to it’s deterioration and not be too anxious about insignificant ones.

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The authors declare that there are no conflicts of interest present.