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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2018-10-92-96</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-2538</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОНКОГЕМАТОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ONCOHEMATOLOGY</subject></subj-group></article-categories><title-group><article-title>Возможности терапии рецидива хронического лимфолейкоза, отягощенного аутоиммунными осложнениями. Данные литературы и собственное наблюдение</article-title><trans-title-group xml:lang="en"><trans-title>Possibilities of therapy recurrent b-cell chronic lymphocytic leukemia associated with autoimmune complications: data from literature and personal observation</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Горячева</surname><given-names>С. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Goryacheva</surname><given-names>S. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кандидат медицинских наук</p></bio><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сорокина</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sorokina</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кандидат медицинских наук</p></bio><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аль-Ради</surname><given-names>Л. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Al-Radi</surname><given-names>L. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кандидат медицинских наук</p></bio><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шерстнев</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sherstnev</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Моисеева</surname><given-names>Т. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Moiseeva</surname><given-names>T. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кандидат медицинских наук</p></bio><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр гематологии» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National medical research center of Hematology, Ministry of health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>18</day><month>07</month><year>2018</year></pub-date><volume>0</volume><issue>10</issue><fpage>92</fpage><lpage>96</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Горячева С.Р., Сорокина Т.В., Аль-Ради Л.С., Шерстнев А.А., Моисеева Т.Н., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Горячева С.Р., Сорокина Т.В., Аль-Ради Л.С., Шерстнев А.А., Моисеева Т.Н.</copyright-holder><copyright-holder xml:lang="en">Goryacheva S.R., Sorokina T.V., Al-Radi L.S., Sherstnev A.M., Moiseeva T.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/2538">https://www.med-sovet.pro/jour/article/view/2538</self-uri><abstract><p>Приведено описание клинического наблюдения успешной терапии ибрутинибом рецидива хронического лимфолейкоза, отягощенного аутоиммунными осложнениями. Обсуждаются причины возникновения аутоиммунных осложнений ХЛЛ, их влияние на прогноз заболевания, а также тактика ведения подобных пациентов.</p></abstract><trans-abstract xml:lang="en"><p>The description of the clinical observation of the successful therapy with ibrutinib recurrent B-cell chronic lymphocytic leukemia associated with autoimmune complications is given. The reasons for occurrence the autoimmune complications of CLL, their effect on the disease prognosis as well as the tactics of conducting similar patients have been considered.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>хронический лимфолейкоз (ХЛЛ)</kwd><kwd>аутоиммунные осложнения ХЛЛ</kwd><kwd>аутоиммунная гемолитическая анемия (АИГА)</kwd><kwd>иммунная тромбоцитопения (ИТП)</kwd><kwd>иммунные цитопении</kwd><kwd>ибрутиниб</kwd></kwd-group><kwd-group xml:lang="en"><kwd>lymphocytic leukemia (CLL)</kwd><kwd>the autoimmune complications of CLL</kwd><kwd>autoimmune hemolytic anemia (AIHA)</kwd><kwd>immune thrombocytopenia (ITP)</kwd><kwd>autoimmune cytopenias (AIC)</kwd><kwd>ibrutinib</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Rai KR, Jain P. Chronic lymphocytic leukemia – Then and now. 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