medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2018-12-164-172medsovet-2582Research ArticleГИНЕКОЛОГИЯGYNECOLOGYВитамин Д и репродуктивное здоровье женщин (обзор литературы)Vitamin D and women’s reproductive health (literature review)ЗайдиеваЯ. З.ZaydievaYa. Z.

д.м.н., профессор

MD, Prof.

БаланВ. Е.BalanV. E.

д.м.н., профессор

MD, Prof.

ГБУЗ МО «Московский областной научно-исследовательский институт акушерства и гинекологии»РоссияThe Moscow Regional Research Institute of Obstetrics and Gynecology, RussiaRussian Federation201827072018012164172Copyright © Зайдиева Я.З., Балан В.Е., 20182018Зайдиева Я.З., Балан В.Е.Zaydieva Y.Z., Balan V.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/2582

Поиск литературы о взаимосвязи между витамином Д и фертильностью у женщин проведен в Pubmed. Рецепторы витамина Д (РВД) и витамин-Д-связанные ферменты были найдены в репродуктивных органах мужчин и женщи н. Предоставлены свидетельства, что витамин Д участвует в репродуктивном здоровье женщин, влияя на результаты искусственного оплодотворения и синдром поликистозных яичников (СПЯ). У женщин с СПЯ низкий уровень 25-гидроксивитамина Д (25(OH) Д) связан с ожирением, метаболическими и гормональными нарушениями, а потребление витамина Д может способствовать регуляции менструального цикла и метаболических нарушений. Более того, витамин Д может влиять на стероидогенез половых гормонов (эстрадиола и прогестерона) у здоровых женщин, при этом высокий уровень 25(OH)Д может быть у женщин с эндометриозом.

 

Vitamin D and women’s reproductive health (literature review). Literature search the relationship between vitamin D and fertility in women рerformed in Pubmed. The vitamin D receptor (VDR) and vitamin D metabolizing enzymes are found in reproductive tissues of women. Moreover, we present evidence that vitamin D is involved in female reproduction including IVF outcome and polycystic ovary syndrome (PCOS). In PCOS women, low 25-hydroxyvitamin D (25(OH)D) levels are associated with obesity, metabolic, and endocrine disturbances and vitamin D supplementation might improve menstrual frequency and metabolic disturbances in those women. Moreover, vitamin D might influence steroidogenesis of sex hormones (estradiol and progesterone) in healthy women and high 25(OH)D levels might be associated with endometriosis.

 

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The authors declare that there are no conflicts of interest present.