medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2018-13-46-49medsovet-2601Research ArticleКонтрацепцияContraceptionНеконтрацептивные эффекты микродозированного фолатсодержащего орального контрацептива у пациенток репродуктивного возрастаNon-contraceptive effects of microdose folate-containing oral contraceptive in patients of child bearing ageСоколоваТ. М.SokolovaT. M.

д.м.н., профессор кафедры акушерства и гинекологии,

Новосибирск

Obstetrics and Gynaecology Department,

Novosibirsk

МакаровК. Ю.MakarovK. Yu.

д.м.н., профессор кафедры акушерства и гинекологии,

Новосибирск

Obstetrics and Gynaecology Department,

Novosibirsk

КиселеваТ. В.KiselevaT. V.

д.м.н., профессор кафедры акушерства и гинекологии,

Новосибирск

Obstetrics and Gynaecology Department,

Novosibirsk

ЯкимоваА. В.YakimovaA. V.

д.м.н., профессор кафедры акушерства и гинекологии,

Новосибирск

Obstetrics and Gynaecology Department,

Novosibirsk

ФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава России, кафедра акушерства и гинекологииРоссияNovosibirsk State Medical University of the Ministry of Health of RussiaRussian Federation2018220920180134649Copyright © Соколова Т.М., Макаров К.Ю., Киселева Т.В., Якимова А.В., 20182018Соколова Т.М., Макаров К.Ю., Киселева Т.В., Якимова А.В.Sokolova T.M., Makarov K.Y., Kiseleva T.V., Yakimova A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/2601

В статье приведена оценка эффективности применения фолатсодержащего орального контрацептива (Джес® Плюс), содержащего гестаген с антиандрогенным и антиминералокортикоидным действием, который кроме предупреждения нежелательной беременности нивелирует симптомы первичной дисменореи, а также имеет зарегистрированные показания для лечения акне.

The article provides a summary of the evaluation of efficacy of folate-containing oral contraceptive (Yaz® plus) containing gestagen with antiandrogenic and antimineralocorticoid effect, which, neutralizes the symptoms of primary dysmenorrhea in addition to preventing unwanted pregnancies, and also has registered indications for the treatment of acne.

фолатсодержащие оральные контрацептивыдроспиренондисменореяакне / гиперандрогенные дермопатииfolate-containing oral contraceptivesdrospirenonedysmenorrheaacne / hyperandrogenic dermopathyReferencesМонахов С.А. Фолатсодержащие антиандрогенные оральные контрацептивы: дерматологические аспекты. Гинекология, 2016, 18(4): 54-8.Monakhov SA. Folate-containing antiandrogen oral contraceptives: dermatological aspects. Ginekologiya, 2016, 18 (4): 54-8.Ледина А.В. Дроспиренонсодержащий контрацептив: лечебные и профилактические аспекты применения. Гинекология, 2015, 1: 25-9.Ledina AV. Drospirenone contraceptive: therapeutic and preventive aspects of use. Ginekologiya, 2015, 1: 25-9.Dawood MY. Primary dysmenorrhea: advances in pathogenesis and management. J Obstet Gynecol. 2006 Aug;108(2):428-41.Dawood MY. Primary dysmenorrhea: advances in pathogenesis and management. J Obstet Gynecol. 2006 Aug;108(2):428-41.Хамошина М.Б., Лебедева М.Г., Артикова Н.Л., Добрецова Т.А., Радзинский В.Е., ред. Управление менструальным циклом: новые возможности. Инновации в контрацепции – гибкий пролонгированный режим и цифровые технологии дозирования: информационный бюллетень. М.: редакция журнала Status Praesens, 2016.Khamoshina MB, Lebedeva MG, Artikova NL, Dobretsova TA, Radzinsky VE, ed. Managing the menstrual cycle: new opportunities. Innovations in contraception: flexible prolonged mode and digital dosing technologies: newsletter. M.: Editorial office of the Journal of Status Praesens, 2016.Мгерян А.Н., Прилепская В.Н. Контрацепция с фолатами – новые грани проблемы. Медицинский совет, 2018, 7: 28-31.Mgeryan AN, Prilepskaya VN. Contraception with folates: new facets of the problem. Meditsinsky Sovet, 2018, 7: 28-31.Katzman M1, Logan AC. Acne vulgaris: nutritional factors may be influencing psychological sequelae. Med Hypotheses. 2007;69(5):1080-4. Epub 2007 Apr 19.Katzman M1, Logan AC. Acne vulgaris: nutritional factors may be influencing psychological sequelae. Med Hypotheses. 2007;69(5):1080-4. Epub 2007 Apr 19.Park JH, Bienenfeld A, Orlow SJ, Nagler AR. The use of hormonal antiandrogen therapy in female patients with acne: a 10-year retrospective study. Am J Clin Dermatol, 2018, 19(3): 449-455.Park JH, Bienenfeld A, Orlow SJ, Nagler AR. The use of hormonal antiandrogen therapy in female patients with acne: a 10-year retrospective study. Am J Clin Dermatol, 2018, 19(3): 449-455.Hernadi L, Marr J, Trummer D et al. Efficasy and safety of a low-dose combined oral contraceptive containing drospirenon 3 mg and ethinylestradiol 20 mcg in 24/4 – day regimen. Contraception, 2009, 80: 18-24. doi: 10.1016/j. contraception.2009.01.016.Hernadi L, Marr J, Trummer D et al. Efficasy and safety of a low-dose combined oral contraceptive containing drospirenon 3 mg and ethinylestradiol 20 mcg in 24/4 – day regimen. Contraception, 2009, 80: 18-24. doi: 10.1016/j. contraception.2009.01.016.Синдром поликистозных яичников в репродуктивном возрасте (современные подходы к диагностике и лечению): клинические рекомендации (протокол лечения). М., 2015. 22 с.Polycystic ovary syndrome in the child bearing age (modern approaches to diagnosis and treatment): clinical guidelines (treatment regimen). M., 2015. 22 p.Oelkers W. Drospirenone – a new progestogen with antimineralocorticoid activity, resemblingnatural progesterone. Eur J Contracept Reprod Health Care, 2000, 5(3): 17-24.Oelkers W. Drospirenone – a new progestogen with antimineralocorticoid activity, resemblingnatural progesterone. Eur J Contracept Reprod Health Care, 2000, 5(3): 17-24.Fruzzetti F, Lazzarini V, Ricci C et al. Effect of an oral contraceptive containing 30 μg ethinylestradiol plus 3 mg drospirenone on body composition of young women affected by premenstrual syndrome with symptoms of water retention. Contraception, 2007, 76: 190- 194.Fruzzetti F, Lazzarini V, Ricci C et al. Effect of an oral contraceptive containing 30 μg ethinylestradiol plus 3 mg drospirenone on body composition of young women affected by premenstrual syndrome with symptoms of water retention. Contraception, 2007, 76: 190- 194.Krikke GG, Grooten IJ, VrijKotte TGM, van Eijsden M, Roseboom TJ, Painter RC. Vitamin B12 and folate status in early pregnancy and cardiometabolic risk factors in the offspring at age 5—6 years: findings from the ABCD multiethnic birth cohort. BJOG, 2016, 123(3): 384- 392. https://doi.org/10.1111/1471-0528.13574.Krikke GG, Grooten IJ, VrijKotte TGM, van Eijsden M, Roseboom TJ, Painter RC. Vitamin B12 and folate status in early pregnancy and cardiometabolic risk factors in the offspring at age 5—6 years: findings from the ABCD multiethnic birth cohort. BJOG, 2016, 123(3): 384- 392. https://doi.org/10.1111/1471-0528.13574.Wang H, Mueller NT, Li J, Sun N, Huo Y, Ren F, Wang X. Association of maternal plasma folate and cardiometabolic risk factors in pregnancy with elevated blood pressure of offspring in childhood. Am J Hypertens, 2017, 30(5): 532-40. https://doi.org/10.1093/ajh/hpx003.Wang H, Mueller NT, Li J, Sun N, Huo Y, Ren F, Wang X. Association of maternal plasma folate and cardiometabolic risk factors in pregnancy with elevated blood pressure of offspring in childhood. Am J Hypertens, 2017, 30(5): 532-40. https://doi.org/10.1093/ajh/hpx003.Smelt AF, Gussekloo J, Bermingham LW. The effect of vitamin B12 and folic acid supplementation on routine haemotological parameters in older people: an individual data metaanalysis. Eur J Clin Nutr, 2018, 72(6): 785-795.Smelt AF, Gussekloo J, Bermingham LW. The effect of vitamin B12 and folic acid supplementation on routine haemotological parameters in older people: an individual data metaanalysis. Eur J Clin Nutr, 2018, 72(6): 785-795.Williams JD, Jacobson EL, Kim H, Kim M, Jacobson MK. Folate in skin cancer preverntion. Subcell Biochem, 2012, 56: 181-97.Williams JD, Jacobson EL, Kim H, Kim M, Jacobson MK. Folate in skin cancer preverntion. Subcell Biochem, 2012, 56: 181-97.Field MS, Kamynina E, Chon J, Stover PJ. Nuclear folate metabolism. Annu Rev Nutr, 2018, 38: 219-243.Field MS, Kamynina E, Chon J, Stover PJ. Nuclear folate metabolism. Annu Rev Nutr, 2018, 38: 219-243.Balashova OA, Visina O, Borodinsky LN. Folate action in nervous system development and disease. Dev Neurobiol, 2018 Apr, 78(4): 391- 402.Balashova OA, Visina O, Borodinsky LN. Folate action in nervous system development and disease. Dev Neurobiol, 2018 Apr, 78(4): 391- 402.Endermani A., Zarghami M., Darvishi-Khezri H. The effects and potential mechanisms of folic acid on cognitive function: a comprehensive review. Neurol Sci, 2018.Endermani A., Zarghami M., Darvishi-Khezri H. The effects and potential mechanisms of folic acid on cognitive function: a comprehensive review. Neurol Sci, 2018.Ansari R, Mahta A, Mallack E, Luo JJ. Hyperhomocysteinemia and Neurologic Disorders: a Review. J Clin Neurol, 2014; 10(4): 281-288.Ansari R, Mahta A, Mallack E, Luo JJ. Hyperhomocysteinemia and Neurologic Disorders: a Review. J Clin Neurol, 2014; 10(4): 281-288.Lazarou Ch, Kapsou M. The role of folic acid in prevention and treatment of depression: An overview of existing evidence and implications for practice. Complement Ther Clin Pract, 2010, 16: 161-166.Lazarou Ch, Kapsou M. The role of folic acid in prevention and treatment of depression: An overview of existing evidence and implications for practice. Complement Ther Clin Pract, 2010, 16: 161-166.Beydoun MA, Shroff MR, Beydoun HA, Zonderman AB. Serum folate, vitamin B-12 and homocysteine and their association with depressive symptoms among US adults. Psychosom Med, 2010, 72(9): 862-873.Beydoun MA, Shroff MR, Beydoun HA, Zonderman AB. Serum folate, vitamin B-12 and homocysteine and their association with depressive symptoms among US adults. Psychosom Med, 2010, 72(9): 862-873.Кузнецова И.В. Метаболические эффекты комбинированной гормональной контрацепции и риск тромботических осложнений. Акушерство и гинекология, 2016, 6: 108-14.Kuznetsova IV. Metabolic effects of combined hormonal contraception and the risk of thrombotic complications. Akusherstvo i Ginekologiya, 2016, 6: 108-14.Фолаты в XXI веке вне беременности. Только доказательные факты. Под ред. В.Е. Радзинского. М.: Status Praesens, 2014.Folates in the 21st century in the non-pregnant state. Only evidence. Under the editorship of Radzinsky VE. M.: Status Praesens, 2014.Diefenbach K, Trummer D, Ebert F et al. Changes in folate levels following cessation of Yasmin and levomefolate calcium 0,451 mg or folic acid 400 mcg co-administration (abstract and poster). Eur J Contracept Reprod Health Care, 2010, 15 (s1): 157-8.Diefenbach K, Trummer D, Ebert F et al. Changes in folate levels following cessation of Yasmin and levomefolate calcium 0,451 mg or folic acid 400 mcg co-administration (abstract and poster). Eur J Contracept Reprod Health Care, 2010, 15 (s1): 157-8.

The authors declare that there are no conflicts of interest present.