medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2018-14-44-49medsovet-2650Research ArticleВОСПАЛИТЕЛЬНЫЕ ЗАБОЛЕВАНИЯ КИШЕЧНИКАINFLAMMATORY BOWEL DISEASEВедолизумаб в лечении воспалительных заболеваний кишечника: кому и как?Vedolizumab in the treatment of inflammatory bowel diseases: whom and how?ГоловенкоА. О.GolovenkoA. O.

к.м.н., гастроэнтеролог,

Москва

Moscow

ГоловенкоО. В.GolovenkoO. V.

д.м.н., профессор кафедры,

Москва

Moscow

ООО «Глобал Медикал Систем»РоссияGlobal Medical System LLCRussian FederationФГБОУ ДПО «Российская медицинская академия непрерывного медицинского образования» Минздрава РоссииРоссияRussian Medical Academy of Continuing Medical Education, Federal State Budgetary Educational Institution of Further Professional Education of the Ministry of Health of RussiaRussian Federation2018091020180144449Copyright © Головенко А.О., Головенко О.В., 20182018Головенко А.О., Головенко О.В.Golovenko A.O., Golovenko O.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/2650

Статья посвящена применению ведолизумаба – селективного ингибитора α4β7-интегринов – в лечении воспалительных заболеваний кишечника (язвенного колита и болезни Крона). Приведены результаты клинических испытаний препарата и опыт применения ведолизумаба в реальной клинической практике. Предоставлены последние доступные сведения о профиле безопасности лекарственного средства. Рассмотрены практические аспекты терапии, такие как определение показаний к лечению, тактика при потере ответа, необходимость комбинации ведолизумаба с иммуносупрессорами, применение препарата у особых категорий пациентов.

The article is devoted to the use of vedolizumab, an α4β7 integrin antagonist, in the treatment of inflammatory bowel diseases (ulcerative colitis and Crohn’s disease). It presents the results of clinical trials of the drug and the experience of using vedolizumab in actual clinical practice. The latest available information about the drug’s safety profile is provided. The authors considered the practical aspects of therapy, such as determining the indications for treatment, tactics in loss of response, the need for a combination of vedolizumab with immunosuppressors, and the use of the drug in specific categories of patients.

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The authors declare that there are no conflicts of interest present.