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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2018-14-90-96</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-2658</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Практика/Исследование</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Practice/Research</subject></subj-group></article-categories><title-group><article-title>Билиарный сладж: решенные и нерешенные вопросы</article-title><trans-title-group xml:lang="en"><trans-title>Biliary sludge: solved and unresolved issues</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Минушкин</surname><given-names>О. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Minushkin</surname><given-names>O. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, заведующий кафедрой гастроэнтерологии,</p><p>Москва</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бурдина</surname><given-names>Е. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Burdina</surname><given-names>E. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, научный руководитель;</p><p>заведующая отделением гастроэнтерологии, ультразвуковых и эндоскопических исследований </p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Новоженова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Novozhenova</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., кафедра гастроэнтерологии;</p><p>врач-терапевт</p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ ДПО ЦГМА Управления делами Президента РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Central State Medical Academy of the Administrative Department of the President of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Поликлиника №2 УДП РФ;&#13;
ФГБУ «Поликлиника №3 Управления делами Президента РФ»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Outpatient Clinic No 3 of the Administrative Department of the President of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ЦГМА УДП РФ;&#13;
ФГБУ «Поликлиника №1 Управления делами Президента РФ»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Outpatient Clinic No 1 of the Administrative Department of the President of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>10</day><month>10</month><year>2018</year></pub-date><volume>0</volume><issue>14</issue><fpage>90</fpage><lpage>96</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Минушкин О.Н., Бурдина Е.Г., Новоженова Е.В., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Минушкин О.Н., Бурдина Е.Г., Новоженова Е.В.</copyright-holder><copyright-holder xml:lang="en">Minushkin O.N., Burdina E.G., Novozhenova E.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/2658">https://www.med-sovet.pro/jour/article/view/2658</self-uri><abstract><p>В статье представлены международные материалы по изучению проблемы билиарного сладжа (БС). Авторы делятся и собственными данными на основании проведенных исследований (одна группа составила 1 107 пациентов с БС; вторая – 208 пациентов с разными формами БС; третья группа – 40 пациентов с естественным течением БС при отсутствии фармакологического воздействия; четвертая – 60 пациентов, по 20 пациентов каждого типа БС) с использованием препарата УДХК Эксхол 500 мг №50 и спазмолитика Спарекс 200 мг №30. Назначение исходной дозы 15 мг/кг/сут препарата Эксхол было эффективно в 97% случаях, и купирование БС достигнуто за 12 недель. Скорость купирования БС зависела от типа (1-й – 4 недели, 2—3-й типы – 8–12 недель).</p></abstract><trans-abstract xml:lang="en"><p>The article presents international materials on studying the issue of biliary sludge (BS). The authors also share their own data resulting from conducted studies, where the first group included 1107 patients with BS; the second – 208 patients with different forms of BS; the third group – 40 patients with regular course of BS, in the absence of pharmacological influence; the fourth group – 60 patients (20 patients for each type of BS) with UDCA Exhol 500 mg No. 50 and antispasmodic agent Sparex 200 mg No 30. Intake of Exhol at an initial dose of 15 mg/kg/day was effective in 97% of cases and BS elimination was achieved in 12 weeks. The BS elimination rate depended on its type (1st – 4 weeks, 2–3rd types – 8–12 weeks).</p></trans-abstract><kwd-group xml:lang="ru"><kwd>билиарный сладж</kwd><kwd>УДХК</kwd><kwd>мебеверин</kwd><kwd>Эксхол</kwd><kwd>Спарекс</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Biliary sludge</kwd><kwd>UDCA</kwd><kwd>mebeverine</kwd><kwd>Exhol</kwd><kwd>sparex</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ильченко A.A. Болезни желчного пузыря и желчных путей. 2011, 358.</mixed-citation><mixed-citation xml:lang="en">Ilchenko AA. Gallbladder and bile duct disorders, 2011, 358.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Мансуров Х.Х. Желчнокаменная болезнь. 1991, 222 с.</mixed-citation><mixed-citation xml:lang="en">Mansurov HH. 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