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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2015-10-28-33</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-267</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КОГНИТИВНЫЕ НАРУШЕНИЯ И ДЕМЕНЦИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>COGNITIVE IMPAIRMENT AND DEMENTIA</subject></subj-group></article-categories><title-group><article-title>Модифицируемые факторы риска и современные подходы к терапии деменции</article-title><trans-title-group xml:lang="en"><trans-title>Modifiable risk factors and current approaches to the treatment of dementia</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Боголепова</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Bogolepova</surname><given-names>A. N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Российский национальный исследовательский медицинский университет им. Н.И. Пирогова<country>Россия</country></aff><aff xml:lang="en">Russian Medical Research University named after N.I. Pirogov<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2015</year></pub-date><volume>0</volume><issue>10</issue><fpage>28</fpage><lpage>33</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Боголепова А.Н., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Боголепова А.Н.</copyright-holder><copyright-holder xml:lang="en">Bogolepova A.N.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/267">https://www.med-sovet.pro/jour/article/view/267</self-uri><abstract><p>Проблема деменции приобретает все большую социальную и медицинскую значимость в современном мире. По данным ВОЗ, во всем мире в 2010 г. было зарегистрировано 35,6 млн больных демен-цией, сегодня их число оценивается как 44 млн [<xref ref-type="bibr" rid="cit1">1</xref>]. К 2030 г. количество больных удвоится и достигнет 65,7 млн человек, а к 2050 г. - 115,4 млн [<xref ref-type="bibr" rid="cit2">2</xref>]. Среди причин развития когнитивного дефицита лидирующее положение занимают цереброваскулярные и нейродегенеративные поражения мозга. Наиболее часто причиной развития деменции является болезнь Альцгеймера (60-70% случаев), второе место отводится сосудистой деменции. Учитывая масштаб этой эпидемии и трудности терапии, важно рассмотреть факторы, коррекция которых позволит уменьшить риск или отсрочить наступление болезни.</p></abstract><trans-abstract xml:lang="en"><p>The problem of dementia is acquiring greater social and medical significance in the modern world. According to the WHO, in 2010, the global number of people suffering from dementia was 35.6 million, and today the number is estimated as 44 million. [<xref ref-type="bibr" rid="cit1">1</xref>] By 2030, the number of patients will double to reach 65.7 million people, and in 2050 - 115.4 million. [<xref ref-type="bibr" rid="cit2">2</xref>] Among the factors for the development of cognitive deficits, the leading are cerebrovascular and neurodegenerative brain lesions. The most common cause of dementia is Alzheimer's disease (60-70% of cases), while the second place is given to vascular dementia. Given the scale of the epidemic and therapeutic challenges, it is important to consider the factors for the disease. Their management could reduce the risk or delay the onset of disease.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>когнитивные нарушения</kwd><kwd>деменция</kwd><kwd>факторы риска</kwd><kwd>Акатинол</kwd><kwd>cognitive impairment</kwd><kwd>dementia</kwd><kwd>risk factors</kwd><kwd>akatinol</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Dementia and Risk Reduction. An analysis of protective and modifiable factors. World Alzheimer Report, 2014.</mixed-citation><mixed-citation xml:lang="en">Dementia and Risk Reduction. An analysis of protective and modifiable factors. World Alzheimer Report, 2014.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Доклад ВОЗ. Деменция: приоритет общественного здравоохранения. 2013. www. who.int.</mixed-citation><mixed-citation xml:lang="en">Доклад ВОЗ. 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