medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2018-15-131-136medsovet-2682Research ArticleИНТЕРСТИЦИАЛЬНЫЕ БОЛЕЗНИ ЛЕГКИХINTERSTITIAL LUNG DISEASEАнтифибротическая терапия идиопатического легочного фиброза: соотношение эффективности и безопасностиAntifibrotic therapy of idiopathic pulmonary fibrosis: efficiency / safety ratioАвдеевС. Н.AvdeevS. N.

Авдеев Сергей Николаевич – чл.-корр. РАН, доктор медицинских наук, профессор, зав. кафедрой пульмонологии.

ТрушенкоН. В.TrushenkoN. V.

Трушенко Наталья Владимирована – кандидат медицинских наук, научный сотрудник лаборатории неинвазивных методов диагностики.

Москва

ФГБОУ ВО Первый МГМУ им. И.М. Сеченова Минздрава РоссииРоссияSechenov First Moscow State Medical University of the Ministry of Health of RussiaRussian FederationФГБУ «НИИ пульмонологии» ФМБА РоссииРоссияResearch Institute of Pulmonology of the Federal Medical-Biological Agency of RussiaRussian Federation201811102018015131136Copyright © Авдеев С.Н., Трушенко Н.В., 20182018Авдеев С.Н., Трушенко Н.В.Avdeev S.N., Trushenko N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/2682

Идиопатический легочный фиброз (ИЛФ) – наиболее распространенная форма идиопатической интерстициальной пневмонии, характеризующаяся неуклонно прогрессирующим течением и плохим прогнозом. В основе ухудшения клинической симптоматики и функционального статуса у больных ИЛФ лежит нарастающий фиброз легких, заканчивающийся изменениями по типу «сотового легкого». На сегодняшний день в качестве лекарственной терапии ИЛФ рекомендуют препараты с антифибротическими свойствами. В представленной статье приведены сведения об эффективности и безопасности данной терапии, даны практические рекомендации по ведению больных ИЛФ, получающих ее.

Idiopathic pulmonary fibrosis (IPF) is the most common form of idiopathic interstitial pneumonia that is characterized by a steadily progressive course and poor prognosis. The worsening pulmonary fibrosis resulting in honeycomb lungs accounts for the deterioration of clinical symptoms and functional status in patients with IPF. Today, the drugs with anti-fibrotic properties are recommend as a drug therapy for IPF. The article provides information on the efficacy and safety of this therapy as well as practical guidelines on the management of patients with IPF receiving such therapy.

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The authors declare that there are no conflicts of interest present.