medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2018-17-66-73medsovet-2698Research ArticleАКТУАЛЬНОACTUALLactobacillus rhamnosus GG: клинические аспекты применения с позиций доказательной медициныLactobacillus rhamnosus GG: clinical aspects of the use from the perspective of evidence-based medicineГореловА. В.GorelovA. V.

Горелов Александр Васильевич – профессор, член-корреспондент РАН, заведующий клиническим отделом инфекционной патологии ФБУН «Центральный научно-исследовательский институт эпидемиологии Роспотребнадзора», профессор кафедры детских болезней ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)

Москва

КаннерЕ. В.KannerЕ. V.

Каннер Екатерина Валерьевна – кандидат медицинских наук, старший научный сотрудник

Москва

МаксимовM. Л.MaximovM. L.

Максимов Максим Леонидович – доктор медицинских наук, профессор кафедры клинической фармакологии и фармакотерапии

ЕрмолаеваА. С.ErmolaevaA. S.

Ермолаева Анна Саввична – кандидат медицинских наук, доцент кафедры клинической фармакологии и пропедевтики внутренних болезней

Москва

 

ВознесенскаяА. А.VoznesenskayaA. A.

Вознесенская Анастасия Александровна

Москва

ДадашеваК. Н.DadashevaK. N.

Дадашева Карина Николаевна – врач-дерматолог

Москва

ФБУН «Центральный научно-исследовательский институт эпидемиологии Роспотребнадзора»; ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский университет)РоссияCentral Research Institute of Epidemiology of Rospotrebnadzor; Sechenov First Moscow State Medical University of the Ministry of Health of Russia (Sechenov University)Russian FederationФБУН «Центральный научно-исследовательский институт эпидемиологии Роспотребнадзора»РоссияCentral Research Institute of Epidemiology of RospotrebnadzorRussian FederationКазанская государственная медицинская академия – филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияKazan State Medical Academy – Branch of the Russian Medical Academy of Continuing Postgraduate Education of the Ministry of Health of RussiaRussian FederationФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский университет)РоссияSechenov First Moscow State Medical University of the Ministry of Health of Russia (Sechenov University)Russian FederationГБУЗ МО «Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского»РоссияVladimirsky Moscow Regional Research Clinical Institute, State Budget Health Institution, Moscow RegionRussian Federation2018201020180176673Copyright © Горелов А.В., Каннер Е.В., Максимов M.Л., Ермолаева А.С., Вознесенская А.А., Дадашева К.Н., 20182018Горелов А.В., Каннер Е.В., Максимов M.Л., Ермолаева А.С., Вознесенская А.А., Дадашева К.Н.Gorelov A.V., Kanner Е.V., Maximov M.L., Ermolaeva A.S., Voznesenskaya A.A., Dadasheva K.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/2698

В настоящем обзоре представлена информация о составе и функциях микробиоты кишечника, ее роли в формировании иммунитета. В настоящее время достаточно широко распространено профилактическое и терапевтическое применение пробиотиков при самых разных патологических состояниях, однако доказанной эффективностью они обладают лишь при некоторых заболеваниях. В данном обзоре приведены сведения об эффективности использования в педиатрической практике пробиотического микроорганизма L. rhamnosus GG как одного из наиболее изученных и апробированных штаммов. Суммированы имеющиеся на сегодняшний день доказательные данные относительно эффективности его использования для лечения острой диареи, профилактики антибиотик-ассоциированной диареи и нозокомиальных инфекций, определено место L. rhamnosus GG в профилактике инфекций дыхательных путей и ЖКТ у детей, рассмотрено лечебное и профилактическое использование при аллергических заболеваниях и других нозологических формах. Особо отмечено влияние L. rhamnosus GG на функционирование иммунной системы. Обнадеживающими являются результаты испытаний этого штамма как адъюванта вакцин. В обзоре описаны молекулярные механизмы действия L. rhamnosus GG, обеспечивающие иммуномодулирующее действие данного штамма. Кроме того, представлены данные о клинической эффективности разрешенного к применению в России синбиотика Нормобакт L, включающего комбинацию LGG (4 х 109) и фруктоолигосахаридов (800 мг) у детей.

This review provides information on the composition and functions of the intestinal microbiota, its role in the immune development. At present, prophylactic and therapeutic uses of probiotics are widely common for a variety of pathological conditions, however they have proven efficacy only in certain diseases. This review provides information on the efficacy of the use of probiotic microorganism L. rhamnosus GG in the paediatric practice as one of the most studied and tested strains. It summarized the currently available evidence on the efficacy of its use for the treatment of acute diarrhea, the prevention of antibiotic-associated diarrhoea and nosocomial infections, defined the role of L. rhamnosus GG in the prevention of respiratory tract infections and gastrointestinal infections in children, considered its therapeutic and preventive use in allergic diseases and other nosological forms. Special attention was paid to the effect of L. rhamnosus GG on the immune system functioning. The results of this strain test as adjuvant vaccines are also encouraging. The review describes the molecular mechanisms of action of L. rhamnosus GG, which provide immunomodulating effect of this strain. In addition, it presents data on the clinical efficacy of Normobact L synbiotic comprising a combination of LGG (4 x 109) and fructooligosaccharides (800 mg), which is approved for use in children in Russia.

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The authors declare that there are no conflicts of interest present.