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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2018-17-146-149</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-2711</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>БРОНХОПУЛЬМОНОЛОГИЯ И ЛОР</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>BRONCHIAL PULMONOLOGY AND ENT</subject></subj-group></article-categories><title-group><article-title>Антибактериальная терапия осложнений острых инфекций верхних дыхательных путей у детей</article-title><trans-title-group xml:lang="en"><trans-title>Antibacterial therapy of complications of acute respiratory viral infections in children</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Делягин</surname><given-names>В. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Delyagin</surname><given-names>W. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Делягин Василий Михайлович – доктор медицинских наук, заведующий отделом клинической физиологии, профессор кафедры педиатрии и организации здравоохранения</p><p>Москва </p><p> </p></bio><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology of the Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>21</day><month>10</month><year>2018</year></pub-date><volume>0</volume><issue>17</issue><fpage>146</fpage><lpage>149</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Делягин В.М., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Делягин В.М.</copyright-holder><copyright-holder xml:lang="en">Delyagin W.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/2711">https://www.med-sovet.pro/jour/article/view/2711</self-uri><abstract><p>Частота острых респираторных инфекций верхних дыхательных путей у детей первых 3 лет жизни может достигать 3796,29:1000. У детей дошкольного возраста из организованных коллективов ежегодно регистрируется до 6–10 эпизодов ОРИ, у школьников младших классов – 7–12. Частота бактериальных осложнений (отит, синусит, трахеобронхит, пневмония) в разных возрастных группах и социоэкономических условиях составляет 10–60%, что требует назначения антибиотиков. В случае тяжелого течения осложнения, при ранее назначаемых препаратах 1-й линии, неблагоприятном преморбидном фоне показано лечение цефиксимом.</p></abstract><trans-abstract xml:lang="en"><p>The incidence of acute respiratory infections (ARI) of the upper respiratory tract in children of the first 3 years of life can reach 3796.29: 1,000. Pre-school children from organized groups register up to 6–10 episodes of ARI annually, and 7–12 in primary school children. The frequency of bacterial complications (otitis, sinusitis, tracheobronchitis, pneumonia) in different age groups and socioeconomic conditions is 10–60%, which requires the appointment of antibiotics. In the case of a severe course of complications, with previously prescribed drugs of the 1st line, an unfavorable premorbid background the treatment with cefixime is preferable.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>дети</kwd><kwd>болезни системы дыхания</kwd><kwd>вирусные инфекции</kwd><kwd>осложнения</kwd><kwd>амбулаторное лечение</kwd><kwd>антибиотики</kwd></kwd-group><kwd-group xml:lang="en"><kwd>children</kwd><kwd>respiratory system diseases</kwd><kwd>viral infections</kwd><kwd>complications</kwd><kwd>outpatient treatment</kwd><kwd>antibiotics</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Делягин В.М., Мальцев В.И., Румянцев А.Г. Лекции по клинической диагностике внутренних болезней. Киев: Морион, 2007. 663 с.</mixed-citation><mixed-citation xml:lang="en">Delyagin VM, Maltsev VI, Rumyantsev AG. Lectures on the clinical diagnosis of internal diseases. Kiev, Morion, 2007. 663 p.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Мельникова М.А. Острые респираторные инфекции с синдромом бронхообструкции у детей первых 3 лет жизни и показатели его рецидивирования. Автореферат к.м.н., М., 2010. 28 с.</mixed-citation><mixed-citation xml:lang="en">Melnikova MA. Acute respiratory infections with bronchial obstruction syndrome in children of the first 3 years of life and indicators of its recurrence. Author’s thesis of PhD in medicine, Moscow, 2010. 28 p.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Grief S. Upper respiratory infections. Prim Care, 2013, 40(3): 757-770.</mixed-citation><mixed-citation xml:lang="en">Grief S. Upper respiratory infections. Prim Care, 2013, 40(3): 757-770.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Eccles R. Understanding the symptoms of the common cold and influenza. Lancet Infect Dis, 2005, 5(11): 718-725.</mixed-citation><mixed-citation xml:lang="en">Eccles R. Understanding the symptoms of the common cold and influenza. Lancet Infect Dis, 2005, 5(11): 718-725.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Heikkinen T, Jarvinen A. The common cold. Lancet, 2003, 361(9351): 51-59.</mixed-citation><mixed-citation xml:lang="en">Heikkinen T, Jarvinen A. The common cold. Lancet, 2003, 361(9351): 51-59.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Vanker A, Gie P, Zar H. The association between environmental tobacco smoke exposure and respiratory disease: a review. Expert Rev Resp Med, 2017, 11(8): 661-673.</mixed-citation><mixed-citation xml:lang="en">Vanker A, Gie P, Zar H. The association between environmental tobacco smoke exposure and respiratory disease: a review. Expert Rev Resp Med, 2017, 11(8): 661-673.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Simoes E, Cheria Th, Chow J, Shahid-Sallas S. et al. Acute respiratory infections in children. In: Hamison D, Breman Th, Moasham A, Alleyne G et al. (Eds.) Disease Control Priorities in Developing Countries. 2nd Ed. New York, NY: Oxford University Press, 2006.</mixed-citation><mixed-citation xml:lang="en">Simoes E, Cheria Th, Chow J, Shahid-Sallas S. et al. Acute respiratory infections in children. In: Hamison D, Breman Th, Moasham A, Alleyne G et al. (Eds.) Disease Control Priorities in Developing Countries. 2nd Ed. New York, NY: Oxford University Press, 2006.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Wald E, Applegate K, Bordley C, Darrow D et al. American Academy of Pediatrics. Clinical practice guideline for the diagnosis and management of acute bacterial sinusitis in children aged 1 to 18 years. Pediatrics, 2013, 132(1): e262-280.</mixed-citation><mixed-citation xml:lang="en">Wald E, Applegate K, Bordley C, Darrow D et al. American Academy of Pediatrics. Clinical practice guideline for the diagnosis and management of acute bacterial sinusitis in children aged 1 to 18 years. Pediatrics, 2013, 132(1): e262-280.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Chonmaitree T, Revail K, Grady J, Clos A et al. Viral upper respiratory tract infection and otitis media complication in young children. Clin Infect Dis, 2008, 46(6): 815-823.</mixed-citation><mixed-citation xml:lang="en">Chonmaitree T, Revail K, Grady J, Clos A et al. Viral upper respiratory tract infection and otitis media complication in young children. Clin Infect Dis, 2008, 46(6): 815-823.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Nokso-Koivisto J, Marom T, Chonmatree T et al. Importance of viruses in acute otitis media. Curr Opin Pediatr, 2015, 27(1): 110-115.</mixed-citation><mixed-citation xml:lang="en">Nokso-Koivisto J, Marom T, Chonmatree T et al. Importance of viruses in acute otitis media. Curr Opin Pediatr, 2015, 27(1): 110-115.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Saux N, Robinson J. Management of acute otitis media in children six months of age and older. Pediatr Child Health, 2016, 21(1): 39-44.</mixed-citation><mixed-citation xml:lang="en">Saux N, Robinson J. Management of acute otitis media in children six months of age and older. Pediatr Child Health, 2016, 21(1): 39-44.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Яковлев С.В., Рафальский В.В., Сидоренко С.В., Спичак Т.В. (ред.). Стратегия и тактика рационального применения антимикробных средств в амбулаторной практике. Российские практические рекомендации. М.: Престо, 2014. 121 с.</mixed-citation><mixed-citation xml:lang="en">Yakovlev SV, Rafalsky VV, Sidorenko SV, Spichak TV. (Ed.) Strategy and tactics of rational use of antimicrobial agents in outpatient practice. Russian practical guidelines. M.: Presto, 2014. 121 p.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Magit A. Pediatric rhinosinusitis. Otolaryngol Clin North Am, 2014, 47(5): 733-746.</mixed-citation><mixed-citation xml:lang="en">Magit A. Pediatric rhinosinusitis. Otolaryngol Clin North Am, 2014, 47(5): 733-746.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Smith M. Evidence for the diagnosis and treatment of acute uncomplicated sinusitis in children: a systematic review. Pediatrics, 2013, 132(1): e284-296.</mixed-citation><mixed-citation xml:lang="en">Smith M. Evidence for the diagnosis and treatment of acute uncomplicated sinusitis in children: a systematic review. Pediatrics, 2013, 132(1): e284-296.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Rose A, Zanation A, Ebert Ch. Chronic rhinosinusitis in children. Pediatr Clin North Am, 2013, 60(4): 979-991.</mixed-citation><mixed-citation xml:lang="en">Rose A, Zanation A, Ebert Ch. Chronic rhinosinusitis in children. Pediatr Clin North Am, 2013, 60(4): 979-991.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Brook I. Acute and chronic bacterial sinusitis. Infect Dis Clin North Am, 2007, 21(2): 427-448.</mixed-citation><mixed-citation xml:lang="en">Brook I. Acute and chronic bacterial sinusitis. Infect Dis Clin North Am, 2007, 21(2): 427-448.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Lindel A, Kelsberg G, Safranek S. Antibiotics for viral upper respiratory tract infection in children. Am Fam Physician, 2011, 83(6): 747-752.</mixed-citation><mixed-citation xml:lang="en">Lindel A, Kelsberg G, Safranek S. Antibiotics for viral upper respiratory tract infection in children. Am Fam Physician, 2011, 83(6): 747-752.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Делягин В.М., Быстрова Н.Ю. Антибактериальные и мукоактивные препараты (краткое руководство для педиатра). М., «АЛТУС», 1999. 70 с.</mixed-citation><mixed-citation xml:lang="en">Delyagin VM, Bystrova NYu. Antibacterial and mucoactive drugs (a brief guide for pediatrician). Moscow, ALTUS. 1999. 70 p.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Таточенко В.К. Антибиотики в арсенале участкового педиатра для лечения болезней органов дыхания. Лечащий врач, 2009, 6: 5-9.</mixed-citation><mixed-citation xml:lang="en">Tatochenko VK. Antibiotics in the arsenal of the district paediatrician for the treatment of respiratory diseases. Lechashchy Vrach, 2009, 6: 5-9</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Pediatric Treatment Recommendations. Centers for disease control and prevention. 2017. https:// www.cdc.gov/antibiotic-use/community/for-hcp/outpatient-hcp/pediatric-treatmentrec.html</mixed-citation><mixed-citation xml:lang="en">Pediatric Treatment Recommendations. Centers for disease control and prevention. 2017. https:// www.cdc.gov/antibiotic-use/community/for-hcp/outpatient-hcp/pediatric-treatmentrec.html</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Савинова Т.А., Сидоренко С.В., Буданов С.В., Грудинина С.А. Динамика распространения резистентности к беталактамным антибиотикам среди Streptococcus pneumoniae и ее клиническая значимость. Антибиотики и химиотерапия, 2010, 55: 12-20.</mixed-citation><mixed-citation xml:lang="en">Savinova TA, Sidorenko SV, Budanov SV, Grudinina SA. The dynamics of the spread of beta-lactam antibiotic resistance in Streptococcus pneumoniae and its clinical significance. Antibiotiki i Khimioterapiya, 2010, 55: 12-20.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Козлов Р.С., Сивая О.В., Кречикова О.И., Иванчик Н.В. «ПеГАС»: Динамика резистентности Streptococcus pneumoniae к антибиотикам в России за период 1999–2009 гг. (Результаты многоцентрового проспективного исследования ПеГАС). Клин. микробиол. антимикроб. химиотер., 2010, 12(4): 329-341.</mixed-citation><mixed-citation xml:lang="en">Kozlov RS, Sivaya OV, Krechikova OI, Ivanchik NV, PeGAS: Dynamics of Streptococcus pneumoniae resistance to antibiotics in Russia over the period of 1999–2009. (Results of multicenter prospective PeGAS study). Klin. Microbiol. Antimicrobial. Khimioter, 2010, 12 (4): 329-341.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Blustone C. Review of cefixime in the treatment of otitis media in infants and children. Pediatr Infect Dis J, 1993, 12(1): 75-82.</mixed-citation><mixed-citation xml:lang="en">Blustone C. Review of cefixime in the treatment of otitis media in infants and children. Pediatr Infect Dis J, 1993, 12(1): 75-82.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Leibovitz E. Acute otitis media in pediatric medicine: current issue in epidemiology, diagnosis and management. Pediatr Drugs, 2003, 5(Suppl. 1): 1-12.</mixed-citation><mixed-citation xml:lang="en">Leibovitz E. Acute otitis media in pediatric medicine: current issue in epidemiology, diagnosis and management. Pediatr Drugs, 2003, 5(Suppl. 1): 1-12.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Cefixime tablets, Cefixime for oral suspension. Product monograph. products.sanofi.ca/en/suprax.pdf.</mixed-citation><mixed-citation xml:lang="en">Cefixime tablets, Cefixime for oral suspension. Product monograph. products.sanofi.ca/en/suprax.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Arroll B, Kenealy T. Antibiotics for the common cold and acute purulent rhinitis. Cochrane Database Syst Rev, 2005, 3: CD000247.</mixed-citation><mixed-citation xml:lang="en">Arroll B, Kenealy T. Antibiotics for the common cold and acute purulent rhinitis. Cochrane Database Syst Rev, 2005, 3: CD000247.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">http://grls.rosminzdrav.ru/grls.aspx?s=Панцеф.</mixed-citation><mixed-citation xml:lang="en">http://grls.rosminzdrav.ru/grls.aspx?s=Панцеф.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
