medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2018-19-32-41medsovet-2744Research ArticleТАРГЕТНАЯ ТЕРАПИЯ ОПУХОЛЕЙTarget therapy of tumorsЦетуксимаб в терапии метастатического колоректального рака: история вопроса и клиническое наблюдениеCetuximab in treatment of metastatic colorectal cancer: background and clinical observationДаренскаяА. Д.DarenskayaA. D.

к.м.н., младший научный сотрудник отделения химиотерапии и комбинированного лечения злокачественных опухолей НИИ клинической онкологии

ДоброваН. В.DobrovaN. V.

к.м.н., старший научный сотрудник отделения химиотерапии и комбинированного лечения злокачественных опухолей НИИ клинической онкологии

МедведеваБ. М.MedvedevaB. M.

д.м.н., ведущий научный сотрудник рентгенодиагностического отделения НИИ клинической и экспериментальной радиологии

ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России, МоскваРоссияBlokhin National Medical Cancer Research Center of the Ministry of Healthcare of Russia, MoscowRussian Federation2018111120180193241Copyright © Даренская А.Д., Доброва Н.В., Медведева Б.М., 20182018Даренская А.Д., Доброва Н.В., Медведева Б.М.Darenskaya A.D., Dobrova N.V., Medvedeva B.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/2744

В настоящее время продолжается поиск наиболее оптимальных режимов лекарственной терапии метастатического колоректального рака (мКРР), в результате использования которых предполагаются увеличение выживаемости без прогрессирования (ВБП) и общей выживаемости (ОВ); улучшение качества жизни пациентов. Благодаря значительному прогрессу в химиотерапии (ХТ) и хирургическом лечении мКРР, использованию мультидисциплинарного подхода алгоритмы лечения больных изменились. Увеличение продолжительности жизни пациентов наблюдается при использовании всех трех наиболее активных при данном заболевании химиопрепаратов: оксалиплатина (Oxa), иринотекана (Iri), фторпиримидинов. Включение таргетного препарата цетуксимаба в современные режимы лечения мКРР привело к статистически достоверному увеличению частоты объективных ответов (ЧОО), медианы ВБП и ОВ. В статье приводятся результаты наиболее значимых клинических исследований, посвященных изучению эффективности анти-EGFR препарата цетуксимаба в комбинации со стандартными режимами ХТ в I и II линиях лекарственного лечения мКРР, а также представлено клиническое наблюдение успешного использования цетуксимаба в терапии мКРР.

Today, the researchers continue the search for the most optimal regimens of drug therapy for metastatic colorectal cancer (mCRC) which are supposed to increase progression-free survival (PFS) and overall survival (OS), improve patient quality of life. Due to significant progress in chemotherapy (CT) and surgical treatment of mCRC, and the multidisciplinary approach, the treatment algorithms have changed. The increase in life expectancy of patients is observed when all three of the most active chemotherapy drugs in this disease: oxaliplatin (Oxa), irinotecan (Iri), fluoropyrimidines are administered. The inclusion of the targeted drug cetuximab in modern mCRC treatment regimens led to a statistically significant increase in the objective response rate (ORR), median PFS and OS. The article presents the results of the most significant clinical studies of the eficacy of the antiEGFR drug cetuximab in combination with standard CT regimens for the first- and second-line treatment of mCRC, and describes a clinical case of the successful use of cetuximab in mCRC therapy.

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The authors declare that there are no conflicts of interest present.