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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2018-19-113-115</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-2757</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Поддерживающая терапия в онкологии</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Supportive care in oncology</subject></subj-group></article-categories><title-group><article-title>Клинический случай лечения тяжелого болевого синдрома комбинацией сильных опиоидов и НПВП у онкологического пациента</article-title><trans-title-group xml:lang="en"><trans-title>Clinical case discussion: treating severe pain syndrome with strong opioids in combination with nsaids in a cancer patient</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сарманаева</surname><given-names>Р. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Sarmanaeva</surname><given-names>R. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач-онколог центра паллиативной помощи онкологическим больным</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абузарова</surname><given-names>Г. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Abuzarova</surname><given-names>G. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., руководитель центра паллиативной помощи онкологическим больным</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Московский научно-исследовательский онкологический институт им. П.А. Герцена — филиал ФГБУ «Национальный медицинский&#13;
исследовательский центр радиологии» Минздрава России, Москва<country>Россия</country></aff><aff xml:lang="en">Hertsen Moscow Research Cencer Institute – branch of National Medical&#13;
Research Radiological Center of the Ministry of Healthcare of Russia, Moscow<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Московский научно-исследовательский онкологический институт им. П.А. Герцена — ффилиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России, Москва<country>Россия</country></aff><aff xml:lang="en">Hertsen Moscow Research Cencer Institute – branch of National Medical&#13;
Research Radiological Center of the Ministry of Healthcare of Russia, Moscow<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>11</day><month>11</month><year>2018</year></pub-date><volume>0</volume><issue>19</issue><fpage>113</fpage><lpage>115</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сарманаева Р.Р., Абузарова Г.Р., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Сарманаева Р.Р., Абузарова Г.Р.</copyright-holder><copyright-holder xml:lang="en">Sarmanaeva R.R., Abuzarova G.R.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/2757">https://www.med-sovet.pro/jour/article/view/2757</self-uri><abstract><p>Подходы к терапии боли у онкологических больных индивидуальны в каждом отдельном случае. Однако есть общие закономерности. Наиболее часто сложности возникают у врачей при переводе пациентов с трамадола на более сильные препараты третьей ступени «лестницы ВОЗ». Назначение и титрация сильных опиоидов до дозы, которая обеспечит адекватный контроль боли при минимальных побочных явлениях, – задача непростая. Здесь врач ориентируется на патогенез боли и учитывает переносимость назначенных препаратов. Индивидуальный подбор адъювантов, способных воздействовать на причину боли, позволяет уменьшить темп эскалации дозы сильных опиоидов, снизить их побочные эффекты. Но как быть, если применение эффективных адъювантов ограниченно? Эти вопросы предлагаются к обсуждению в данной статье.</p></abstract><trans-abstract xml:lang="en"><p>Approaches to treating pain in cancer patients are individual in each case. However, there are general principals. Most often, physicians encounter difficulties when transfer patients from tramadol to more potent tertiary preparations of WHO Analgesic Ladder. The administration and titration of strong opioids to a dose that will ensure adequate pain control with minimal side effects is not an easy task. Here, the physician focuses on the pathogenesis of pain and takes into account the tolerability of drugs prescribed. Individual selection of adjuvants that can affect the cause of pain can reduce the rate of strong opioid dose escalation their side effects. However, what to do, if the use of effective adjuvants is limited? The article provides the discussion of these issues.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>онкология</kwd><kwd>терапия хронической боли</kwd><kwd>сильные опиоидные анальгетики</kwd><kwd>НПВП</kwd><kwd>клиническое применение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>oncology</kwd><kwd>chronic pain therapy</kwd><kwd>strong opioid analgesics</kwd><kwd>NSAIDs</kwd><kwd>clinical use</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Mishra S., Bhatnagar S., Gupta D. et al. Management of neiropatic cancer pain following WHO analgesic ladder: A prospective study. Am J Hosp Palliat Med, 2009, 26(6): 447-51.</mixed-citation><mixed-citation xml:lang="en">Mishra S., Bhatnagar S., Gupta D. et al. Management of neiropatic cancer pain following WHO analgesic ladder: A prospective study. 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