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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2018-18-76-84</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-2797</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>РЕВМАТОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>RHEUMATOLOGY</subject></subj-group></article-categories><title-group><article-title>Персонификация применения нестероидных противовоспалительных препаратов при скелетно­мышечных заболеваниях. Резолюция по результатам совещания экспертов от 13 декабря 2017 года</article-title><trans-title-group xml:lang="en"><trans-title>Personalization of the use of non-steroidal anti-inflammatory drugs for musculoskeletal diseases. Resolution on the results of the Meeting of Experts of December 13, 2017</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каратеев</surname><given-names>А. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Karateev</surname><given-names>A. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Каратеев Андрей Евгеньевич – доктор медицинских наук, заведующий лабораторией патофизиологии боли и полиморфизма скелетно-мышечных заболеваний.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лила</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Lila</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лила Александр Михайлович  – доктор медицинских наук, профессор, директор.</p><p>Москв</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дыдыкина</surname><given-names>И. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Dydykina</surname><given-names>I. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дыдыкина Ирина Степановна – кандидат медицинских наук, ведущий научный сотрудник лаборатории мониторинга безопасности антиревматических препаратов.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Камчатнов</surname><given-names>П. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Kamchatnov</surname><given-names>P. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Камчатнов Павел Рудольфович – доктор медицинских наук, профессор кафедры неврологии, нейрохирургии и медицинской генетики лечебного факультета.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мазуренко</surname><given-names>С. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Mazurenko</surname><given-names>S. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мазуренко Сергей Олегович – доктор медицинских наук, профессор, заведующий кафедрой пропедевтики внутренних болезней СПГУ, руководитель центра остеопороза и метаболических заболеваний скелета КБ 122 им. Л.Г. Соколова</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Наприенко</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Naprienko</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Наприенко Маргарита Валентиновна – доктор медицинских наук, профессор кафедры интегративной медицины ПМГМУ им. И.М. Сеченова, главный врач КГБ им. акад. А.М. Вейна.</p><p>Москва</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Новикова</surname><given-names>Д. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Novikova</surname><given-names>D. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Новикова Диана Сергеевна – доктор медицинских наук, заведующая лабораторией ревмокардиологии.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Островерхов</surname><given-names>О. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Ostroverkhov</surname><given-names>O. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Островерхов Олег Павлович – кандидат медицинских наук, доцент кафедры клинической фармакологии</p></bio><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пчелинцев</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Pchelintsev</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пчелинцев Михаил Владимирович – кандидат медицинских наук, доцент кафедры клинической фармакологии</p></bio><xref ref-type="aff" rid="aff-6"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ Научно-исследовательский институт ревматологии им. В.А. Насоновой</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Nasonova Research Institute of Reumatology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО Российский национальный исследовательский медицинский университет им. Н.И. Пирогова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБОУ ВО Санкт-Петербургский государственный университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>St. Petersburg State University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФГАОУ ВО Первый Московский государственный медицинский универститет им. И.М. Сеченова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov First Moscow State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>ФГБОУ ВО Астраханский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Astrakhan State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-6"><aff xml:lang="ru"><institution>ГБОУ ВПО Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pavlov First Saint Petersburg State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>17</day><month>11</month><year>2018</year></pub-date><volume>0</volume><issue>18</issue><fpage>76</fpage><lpage>84</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Каратеев А.Е., Лила А.М., Дыдыкина И.С., Камчатнов П.Р., Мазуренко С.О., Наприенко М.В., Новикова Д.С., Островерхов О.П., Пчелинцев М.В., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Каратеев А.Е., Лила А.М., Дыдыкина И.С., Камчатнов П.Р., Мазуренко С.О., Наприенко М.В., Новикова Д.С., Островерхов О.П., Пчелинцев М.В.</copyright-holder><copyright-holder xml:lang="en">Karateev A.E., Lila A.M., Dydykina I.S., Kamchatnov P.R., Mazurenko S.O., Naprienko M.V., Novikova D.S., Ostroverkhov O.P., Pchelintsev M.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/2797">https://www.med-sovet.pro/jour/article/view/2797</self-uri><abstract><p>Одним из инновационных и все более и более набирающих силу подходов в современной медицине является персонификация терапии, подразумевающая индивидуальный подход к каждому больному, с учетом индивидуальных особенностей пациента и конкретного клинического случая. Именно с позиций персонифицированной терапии следует планировать проведение рациональной анальгетической терапии, важнейшего компонента ведения больных с наиболее распространенными и социально значимыми заболеваниями, с состояниями, оказывающими значительное влияние на качество жизни человека и ухудшающими течение сопутствующих заболеваний. В ходе совещания экспертов разных специальностей: ревматологов, неврологов, кардиологов и клинических фармакологов – были рассмотрены ключевые аспекты назначения НПВП – наиболее широко используемого класса обезболивающих средств, используемых в т. ч. и для купирования скелетно-мышечной боли. Было отмечено, что при выборе НПВП врач должен учитывать диагноз, планируемую длительность анальгетической терапии, интенсивность болевых ощущений, анамнестические данные, наличие коморбидных заболеваний и факторов риска лекарственных осложнений. Существуют разные типы НПВП, одни из которых наиболее целесообразно использовать для ургентной терапии острой боли (например, кетопрофен), а другие в наибольшей степени подходят для длительного контроля боли при хронических заболеваниях (например, эторикоксиб). В любом случае врач должен учитывать приоритет безопасности больного и уделять самое пристальное внимание профилактике НПВП-ассоциированных осложнений, а также учитывать разрешенную инструкцией по медицинскому применению продолжительность приема конкретного препарата. Также было отмечено, что появление нового генерика эторикоксиба (Костарокс®) расширяет возможности анальгетической терапии для российских врачей.</p></abstract><trans-abstract xml:lang="en"><p>The personalization of therapy is one of the innovative approaches gaining an increasingly strong foothold in modern medicine, implying an individual approach to each patient, taking into account the individual characteristics of the patient and the specific clinical case. This same standpoint of personified therapy should be used to plan rational analgesic therapy, the most important component of managing patients with the most common and socially significant diseases, with conditions that have a significant impact on the patient’s quality of life and worsen the course of concomitant diseases. The Meeting of Experts of different specialties such as rheumatologists, neurologists, cardiologists and clinical pharmacologists considered the key aspects of the prescription of NSAIDs, the most widely used class of painkillers, including those used for the relief of musculoskeletal pain. It was noted that when choosing NSAIDs, the practitioner should take into account the diagnosis, the planned duration of  analgesic therapy, the intensity of pain, medical history data, the presence of comorbid diseases and risk factors for drug complications. There are different types of NSAIDs, some of which are most useful for urgent acute pain therapy (eg, ketoprofen), while others are most suitable for long-term pain management in chronic diseases (eg, etoricoxib). In any case, the practitioner should take into account the priority of patient safety and pay the utmost attention to the prevention of NSAIDassociated complications, and also keep in mind the duration of the specific drug administration permitted by the patient information leaflet. It was also noted that the launch of a new generic etoricoxib (Kostarox®) expands the possibilities of analgesic therapy for the Russian practitioners.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>боль</kwd><kwd>скелетно-мышечные заболевания</kwd><kwd>неспецифическая боль в спине</kwd><kwd>остеоартрит</kwd><kwd>анальгетическая терапия</kwd><kwd>НПВП</kwd><kwd>нежелательные явления</kwd><kwd>профилактика</kwd><kwd>кетопрофен</kwd><kwd>эторикоксиб</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pain</kwd><kwd>musculoskeletal diseases</kwd><kwd>nonspecific back pain</kwd><kwd>osteoarthritis</kwd><kwd>analgesic therapy</kwd><kwd>NSAIDs</kwd><kwd>adverse events</kwd><kwd>prevention</kwd><kwd>ketoprofen</kwd><kwd>etoricoxib</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Сандоз, компания</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Боль (практическое руководство для врачей). 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