medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2018-21-216-230medsovet-2840Research ArticleПрактикаPracticeДотации магния и витамина В2 – важный нутрициологический ресурс спортивной медициныMagnesium and vitamin B2 supplementation is an important nutritional resource of sports medicineГромоваО. А.GromovaO. A.

Громова Ольга Алексеевна – доктор медицинских наук, профессор, ведущий научный сотрудник, научный руководитель Института фармакоинформатики, Федеральный исследовательский центр «Информатика и управление» РАН

119333, Москва, ул. Вавилова, д. 44, корп. 2, 

119991, Москва, Ленинские горы, д. 1

Gromova Olga Alexeevna – Dr. of Sci. (Med.), Professor, Leading Researcher, Scientific Director of the Institute of Pharmacoinformatics, Federal Research Center «Informatics and Management» of the Russian Academy of Sciences

44, Bldg. 2 Vavilova, Moscow, 119333, 

1 Leninskie Gorky, Moscow, 119991

unesco.gromova@gmail.comТоршинИ. Ю.TorshinI. Yu.

Торшин Иван Юрьевич – кандидат химических наук, старший научный сотрудник, Институт фармакоинформатики, Федеральный исследовательский центр «Информатика и управление» РАН; Центр хранения и анализабольших данных, Федеральное государственное бюджетное образовательное учреждение высшего образования «Московский государственный университет имени М.В. Ломоносова»

119333, Москва, ул. Вавилова, д. 44, корп. 2, 

119991, Москва, Ленинские горы, д. 1

Torshin Ivan Yurievich – Cand. of Sci. (Chem.), Senior Researcher, Institute of Pharmacoinformatics, Federal Research Center «Informatics and Management» of the Russian Academy of Sciences

1 Leninskie Gorky, Moscow, 119991

СорокинаМ. А.SorokinaM. A.

Сорокина Мария Андреевна – аспирант

119991, Москва, ул. Косыгина, д. 4

Sorokina Maria Andreevna – Postgraduate Student

4 Kosygina Str., Moscow, 119991

ГромовА. Н.GromovA. N.

Громов Андрей Николаевич – научный сотрудник отдела интеллектуальных систем

119333, Москва, ул. Вавилова, д. 44, корп. 2

Gromov Andrey Nikolaevich – Researcher, Department of Intelligent Systems

44, Bldg. 2 Vavilova, Moscow, 119333

Федеральный исследовательский центр «Информатика и управление» Российской академии наук, Институт фармакоинформатики; Центр хранения и анализа больших данных, Федеральное государственное бюджетное образовательное учреждение высшего образования «Московский государственный университет имени М.В. Ломоносова»РоссияFederal Research Center «Informatics and Management» of the Russian Academy of Sciences, Institute of Pharmacoinformatics; Big Data Storage & Analysis Center, Federal State Budgetary Educational Institution of Higher Education «Lomonosov Moscow State University»Russian FederationФедеральный исследовательский центр «Информатика и управление» Российской академии наук, Институт фармакоинформатики; Центр хранения и анализа больших данных, Федеральное государственное бюджетное образовательное учреждение высшего образования «Московский государственный университет имени М.В. Ломоносова»РоссияBig Data Storage & Analysis Center, Federal State Budgetary Educational Institution of Higher Education «Lomonosov Moscow State University»Russian FederationФедеральное государственное бюджетное учреждение науки «Центр теоретических проблем физико-химической фармакологии РАН»РоссияFederal State Budgetary Institution of Science «Center for Theoretical Problems of Physico-Chemical Pharmacology RAS»Russian FederationФедеральный исследовательский центр «Информатика и управление» Российской академии наук, Институт фармакоинформатикиРоссияFederal Research Center «Informatics and Management» of the Russian Academy of Sciences, Institute of PharmacoinformaticsRussian Federation201820012019021216230Copyright © Громова О.А., Торшин И.Ю., Сорокина М.А., Громов А.Н., 20192019Громова О.А., Торшин И.Ю., Сорокина М.А., Громов А.Н.Gromova O.A., Torshin I.Y., Sorokina M.A., Gromov A.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/2840

Обеспеченность организма магнием и витамином В2 принципиально необходима для поддержания энергетического метаболизма клеток, гормонального баланса, выносливости, иммунитета, сердечно-сосудистого здоровья спортсменов. Как результат, полная обеспеченность этими микронутриентами позволяет повышать максимальную аэробную мощность, достигать лучших спортивных результатов и адекватного восстановления после соревнований и интенсивных тренировок. Перспективным способом повышения обеспеченности спортсменов магнием и витамином В2 является использование водных растворов цитрата магния в сочетании с рибофлавином.

The supply of the with magnesium and vitamin B2 is essential to maintain the energy metabolism of cells, hormonal balance, endurance, immunity, cardiovascular health of athletes. As a result, by increasing the availability of these micronutrients, it is possible to increase maximum aerobic power, achieve better sports results and stimulate adequate recovery after competition or after intensive training. A promising way to increase the supply of athletes with magnesium and vitamin B2 is the use of aqueous solutions of magnesium citrate in combination with riboflavin.

спортивная медицинамикронутриентыМагнесол В2систематический анализsports medicinemicronutrientsMagnesol-B2systematic analysisReferencesWilliams M.H. Vitamin supplementation and athletic performance. Int J Vitam Nutr Res Suppl. 1989; 30: 163-191.Williams M.H. Vitamin supplementation and athletic performance. Int J Vitam Nutr Res Suppl. 1989; 30: 163-191.Eskici G. The Importance of Vitaminsfor Soccer Players. Int J Vitam Nutr Res. 2015; 85(5-6): 225244 doi.Eskici G. The Importance of Vitaminsfor Soccer Players. Int J Vitam Nutr Res. 2015; 85(5-6): 225244 doi.Lukaski H.C. Magnesium, zinc, and chromium nutrition and athletic performance. Can J Appl Physiol. 2001; 26 Suppl: S13-S22.Lukaski H.C. Magnesium, zinc, and chromium nutrition and athletic performance. Can J Appl Physiol. 2001; 26 Suppl: S13-S22.Speich M., Pineau A., Ballereau F. Minerals, trace elements and related biological variables in athletes and during physical activity. Clin Chim Acta. 2001; 312(1-2): 1-11.Speich M., Pineau A., Ballereau F. Minerals, trace elements and related biological variables in athletes and during physical activity. Clin Chim Acta. 2001; 312(1-2): 1-11.Volpe S.L. Magnesium and the Athlete. Curr Sports Med Rep. 2015; 14(4):279-83 doi.Volpe S.L. Magnesium and the Athlete. Curr Sports Med Rep. 2015; 14(4):279-83 doi.Громова О.А., Торшин И.Ю. Магний и «болезни цивилизации». М.: ГЭОТАР-Медиа, 2018. 800 с.: ил.; 25 см. Библиогр. в конце кн. 3000 экз. ISBN 978-5-9704-4527-3.Gromova O.A., Torshin I.Yu. Magnesium and “diseases of civilization.” M.: GEOTAR-Media, 2018. 800 p.: or; 25 cm. Reference is at the end of the book. 3000 copies ISBN 978-5-9704-4527-3. (In Russ).Zhang Y., Xun P., Wang R., Mao L., He K. Can Magnesium Enhance Exercise Performance? Nutrients. 2017;9(9). pii: nu9090946 doi.Zhang Y., Xun P., Wang R., Mao L., He K. Can Magnesium Enhance Exercise Performance? Nutrients. 2017;9(9). pii: nu9090946 doi.van Dronkelaar C., van Velzen A., Abdelrazek M., van der Steen A., Weijs P.J.M., Tieland M. Minerals and Sarcopenia; The Role of Calcium, Iron, Magnesium, Phosphorus, Potassium, Selenium, Sodium, and Zinc on Muscle Mass, Muscle Strength, and Physical Performance in Older Adults: A Systematic Review. J Am Med Dir Assoc. 2018;19(1):6-11e3 doi.van Dronkelaar C., van Velzen A., Abdelrazek M., van der Steen A., Weijs P.J.M., Tieland M. Minerals and Sarcopenia; The Role of Calcium, Iron, Magnesium, Phosphorus, Potassium, Selenium, Sodium, and Zinc on Muscle Mass, Muscle Strength, and Physical Performance in Older Adults: A Systematic Review. J Am Med Dir Assoc. 2018;19(1):6-11e3 doi.Silva M.R., Paiva T. Poor precompetitive sleep habits, nutrients’ deficiencies, inappropriate body composition and athletic performance in elite gymnasts. Eur J Sport Sci. 2016;16(6):726-35 doi.Silva M.R., Paiva T. Poor precompetitive sleep habits, nutrients’ deficiencies, inappropriate body composition and athletic performance in elite gymnasts. Eur J Sport Sci. 2016;16(6):726-35 doi.Madden R.F., Shearer J., Parnell J.A. Evaluation of Dietary Intakes and Supplement Use in Paralympic Athletes. Nutrients. 2017;9(11). pii: nu9111266 doi.Madden R.F., Shearer J., Parnell J.A. Evaluation of Dietary Intakes and Supplement Use in Paralympic Athletes. Nutrients. 2017;9(11). pii: nu9111266 doi.Wardenaar F., Brinkmans N., Ceelen I., Van Rooij B., Mensink M., Witkamp R., De Vries J. Micronutrient Intakes in 553 Dutch Elite and Sub-Elite Athletes: Prevalence of Low and High Intakes in Users and Non-Users of Nutritional Supplements. Nutrients. 2017;9(2). pii: nu9020142 doi.Wardenaar F., Brinkmans N., Ceelen I., Van Rooij B., Mensink M., Witkamp R., De Vries J. Micronutrient Intakes in 553 Dutch Elite and Sub-Elite Athletes: Prevalence of Low and High Intakes in Users and Non-Users of Nutritional Supplements. Nutrients. 2017;9(2). pii: nu9020142 doi.Laires M.J., Monteiro C.P., Bicho M. Role of cellular magnesium in health and human disease. Front Biosci. 2004;9:262-276.Laires M.J., Monteiro C.P., Bicho M. Role of cellular magnesium in health and human disease. Front Biosci. 2004;9:262-276.Rayssiguier Y., Guezennec C.Y., Durlach J. New experimental and clinical data on the relationship between magnesium and sport. Magnes Res. 1990;3(2):93-102.Rayssiguier Y., Guezennec C.Y., Durlach J. New experimental and clinical data on the relationship between magnesium and sport. Magnes Res. 1990;3(2):93-102.Terink R., Balvers M.G.J., Hopman M.T., Witkamp R.F., Mensink M., Gunnewiek J.M.T.K. Decrease in Ionized and Total Magnesium Blood Concentrations in Endurance Athletes Following an Exercise Bout Restores within Hours-Potential Consequences for Monitoring and Supplementation. Int J Sport Nutr Exerc Metab. 2017;27(3):264-270 doi.Terink R., Balvers M.G.J., Hopman M.T., Witkamp R.F., Mensink M., Gunnewiek J.M.T.K. Decrease in Ionized and Total Magnesium Blood Concentrations in Endurance Athletes Following an Exercise Bout Restores within Hours-Potential Consequences for Monitoring and Supplementation. Int J Sport Nutr Exerc Metab. 2017;27(3):264-270 doi.Cohen I., Zimmerman A.L. Changes in serum electrolyte levels during marathon running. S Afr Med J. 1978;53(12):449-453.Cohen I., Zimmerman A.L. Changes in serum electrolyte levels during marathon running. S Afr Med J. 1978;53(12):449-453.Buchman A.L., Keen C., Commisso J., Killip D., Ou C.N., Rognerud C.L., Dennis K., Dunn J.K. The effect of a marathon run on plasma and urine mineral and metal concentrations. J Am Coll Nutr. 1998;17(2):124-127.Buchman A.L., Keen C., Commisso J., Killip D., Ou C.N., Rognerud C.L., Dennis K., Dunn J.K. The effect of a marathon run on plasma and urine mineral and metal concentrations. J Am Coll Nutr. 1998;17(2):124-127.Wenk C., Kuhnt M., Kunz P., Steiner G. Methodological studies of the estimation of loss of sodium, potassium, calcium and magnesium through the skin during a 10 km run. Z Ernahrungswiss. 1993;32(4):301-307.Wenk C., Kuhnt M., Kunz P., Steiner G. Methodological studies of the estimation of loss of sodium, potassium, calcium and magnesium through the skin during a 10 km run. Z Ernahrungswiss. 1993;32(4):301-307.Laires M.J., Alves F. Changes in plasma, erythrocyte, and urinary magnesium with prolonged swimming exercise. Magnes Res. 1991;4(2):119122.Laires M.J., Alves F. Changes in plasma, erythrocyte, and urinary magnesium with prolonged swimming exercise. Magnes Res. 1991;4(2):119122.Molina-Lopez J., Molina J.M., Chirosa L.J., Florea D., Saez L., Millan E., Planells E. Association between erythrocyte concentrations of magnesium and zinc in high-performance handball players after dietary magnesium supplementation. Magnes Res. 2012;25(2):79-88 doi.Molina-Lopez J., Molina J.M., Chirosa L.J., Florea D., Saez L., Millan E., Planells E. Association between erythrocyte concentrations of magnesium and zinc in high-performance handball players after dietary magnesium supplementation. Magnes Res. 2012;25(2):79-88 doi.Rama R, Ibanez J, Pages T, Callis A, Palacios L. Plasma and red blood cell magnesium levels and plasma creatinine after a 100 km race. Rev Esp Fisiol. 1993;49(1):43-47.Rama R, Ibanez J, Pages T, Callis A, Palacios L. Plasma and red blood cell magnesium levels and plasma creatinine after a 100 km race. Rev Esp Fisiol. 1993;49(1):43-47.Lijnen P., Hespel P., Fagard R., Lysens R., Vanden Eynde E., Amery A. Erythrocyte, plasma and urinary magnesium in men before and after a marathon. Eur J Appl Physiol Occup Physiol. 1988;58(3):252-256.Lijnen P., Hespel P., Fagard R., Lysens R., Vanden Eynde E., Amery A. Erythrocyte, plasma and urinary magnesium in men before and after a marathon. Eur J Appl Physiol Occup Physiol. 1988;58(3):252-256.Malliaropoulos N., Tsitas K., Porfiriadou A., Papalada A., R Ames P., Del Buono A., Lippi G., Maffulli N. Blood phosphorus and magnesium levels in 130 elite track and field athletes. Asian J Sports Med. 2013;4(1):49-53 Epub 2012 Nov.Malliaropoulos N., Tsitas K., Porfiriadou A., Papalada A., R Ames P., Del Buono A., Lippi G., Maffulli N. Blood phosphorus and magnesium levels in 130 elite track and field athletes. Asian J Sports Med. 2013;4(1):49-53 Epub 2012 Nov.Scherr J., Schuster T., Pressler A., Roeh A., Christle J., Wolfarth B., Halle M. Repolarization perturbation and hypomagnesemia after extreme exercise. Med Sci Sports Exerc. 2012;44(9):1637-43 doi.Scherr J., Schuster T., Pressler A., Roeh A., Christle J., Wolfarth B., Halle M. Repolarization perturbation and hypomagnesemia after extreme exercise. Med Sci Sports Exerc. 2012;44(9):1637-43 doi.Zhao J., Fan B., Wu Z., Xu M., Luo Y. Serum zinc is associated with plasma leptin and Cu-Zn SOD in elite male basketball athletes. J Trace Elem Med Biol. 2015;30:49-53 doi.Zhao J., Fan B., Wu Z., Xu M., Luo Y. Serum zinc is associated with plasma leptin and Cu-Zn SOD in elite male basketball athletes. J Trace Elem Med Biol. 2015;30:49-53 doi.Громова О.А., Калачева А.Г., Торшин И.Ю. и др. Недостаточность магния – достоверный фактор риска коморбидных состояний: результаты крупномасштабного скрининга магниевого статуса в регионах России. Фарматека. 2013;6:116-129.Gromova O.A., Kalacheva A.G., Torshin I.Yu, et al. Magnesium deficiency: a significant risk factor for comorbid conditions: results of large-scale screening of magnesium status in the Russian regions. Pharmateca. 2013; 6: 116-129. (In Russ).Громова О.А., Лиманова О.А., Гоголева И.В. и др. Анализ взаимосвязи между обеспеченностью магнием и соматической патологией у россиянок 18–45 лет методами интеллектуального анализа данных Эффективная фармакотерапия. Акушерство и гинекология. 2014;2:10–23.Gromova O.A., Limanova O.A., Gogoleva I.V., et al. Analysis of the relationship between magnesium sufficiency and somatic pathology in Russian women aged 18–45 using data mining methods. Effective pharmacotherapy. Akusherstvo i Ginekologiya. 2014; 2: 10–23. (In Russ).Громова О.А., Калачева А.Г., Торшин И.Ю., Гришина Т.Р., Семенов В.А. Диагностика дефицита магния. Концентрации магния в биосубстратах в норме и при различной патологии. Кардиология. 2014; 10: 63-71.Gromova O.A., Kalacheva A.G., Torshin I.Yu., Grishina, T.R., Semenov V.A. Diagnosis of magnesium deficiency. Magnesium concentrations in biosubstrates: norm and various pathologies. Kardiologia. 2014; 10: 63-71 (In Russ).Stendig-Lindberg G. Is physical working capacity determined by optimal magnesium concentration? J Basic Clin Physiol Pharmacol. 1992;3(2):139-151.Stendig-Lindberg G. Is physical working capacity determined by optimal magnesium concentration? J Basic Clin Physiol Pharmacol. 1992;3(2):139-151.Conn C.A., Schemmel R.A., Smith B.W., Ryder E., Heusner W.W., Ku P.K. Plasma and erythrocyte magnesium concentrations and correlations with maximum oxygen consumption in nineto twelve-year-old competitive swimmers. Magnesium. 1988;7(1):27-36.Conn C.A., Schemmel R.A., Smith B.W., Ryder E., Heusner W.W., Ku P.K. Plasma and erythrocyte magnesium concentrations and correlations with maximum oxygen consumption in nineto twelve-year-old competitive swimmers. Magnesium. 1988;7(1):27-36.Cordova A., Escanero J.F., Gimenez M. Magnesium distribution in rats after maximal exercise in air and under hypoxic conditions. Magnes Res. 1992;5(1):23-27.Cordova A., Escanero J.F., Gimenez M. Magnesium distribution in rats after maximal exercise in air and under hypoxic conditions. Magnes Res. 1992;5(1):23-27.Lukaski H.C., Bolonchuk W.W., Klevay L.M., Milne D.B., Sandstead H.H. Maximal oxygen consumption as related to magnesium, copper, and zinc nutriture. Am J Clin Nutr. 1983;37(3):407-415.Lukaski H.C., Bolonchuk W.W., Klevay L.M., Milne D.B., Sandstead H.H. Maximal oxygen consumption as related to magnesium, copper, and zinc nutriture. Am J Clin Nutr. 1983;37(3):407-415.Duma E., Orbai P., Derevenco P. Blood levels of some electrolytes and hormones during exercise in athletes. Rom J Physiol. 1998;35(1-2):55-60.Duma E., Orbai P., Derevenco P. Blood levels of some electrolytes and hormones during exercise in athletes. Rom J Physiol. 1998;35(1-2):55-60.Cinar V., Mogulkoc R., Baltaci A.K., Polat Y. Adrenocorticotropic hormone and cortisol levels in athletes and sedentary subjects at rest and exhaustion: effects of magnesium supplementation. Biol Trace Elem Res. 2008;121(3):215-20 Epub 2007 No.Cinar V., Mogulkoc R., Baltaci A.K., Polat Y. Adrenocorticotropic hormone and cortisol levels in athletes and sedentary subjects at rest and exhaustion: effects of magnesium supplementation. Biol Trace Elem Res. 2008;121(3):215-20 Epub 2007 No.Cinar V. The effects of magnesium supplementation on thyroid hormones of sedentars and Tae-Kwon-Do sportsperson at resting and exhaustion. Neuro Endocrinol Lett. 2007;28(5):708-712.Cinar V. The effects of magnesium supplementation on thyroid hormones of sedentars and Tae-Kwon-Do sportsperson at resting and exhaustion. Neuro Endocrinol Lett. 2007;28(5):708-712.Cinar V., Polat Y., Baltaci A.K., Mogulkoc R. Effects of magnesium supplementation on testosterone levels of athletes and sedentary subjects at rest and after exhaustion. Biol Trace Elem Res. 2011;140(1):18-23 doi.Cinar V., Polat Y., Baltaci A.K., Mogulkoc R. Effects of magnesium supplementation on testosterone levels of athletes and sedentary subjects at rest and after exhaustion. Biol Trace Elem Res. 2011;140(1):18-23 doi.Soria M., Gonzalez-Haro C., Anson M.A., Inigo C., Calvo M.L., Escanero J.F. Variations in serum magnesium and hormonal levels during incremental exercise. Magnes Res. 2014;27(4):155-64 doi.Soria M., Gonzalez-Haro C., Anson M.A., Inigo C., Calvo M.L., Escanero J.F. Variations in serum magnesium and hormonal levels during incremental exercise. Magnes Res. 2014;27(4):155-64 doi.Wienecke E., Nolden C. Long-term HRV analysis shows stress reduction by magnesium intake. MMW Fortschr Med. 2016;158(Suppl):12-16.Wienecke E., Nolden C. Long-term HRV analysis shows stress reduction by magnesium intake. MMW Fortschr Med. 2016;158(Suppl):12-16.Mooren F.C. Magnesium and disturbances in carbohydrate metabolism. Diabetes Obes Metab. 2015;17(9):813-23.Mooren F.C. Magnesium and disturbances in carbohydrate metabolism. Diabetes Obes Metab. 2015;17(9):813-23.Kass L.S., Poeira F. The effect of acute vs chronic magnesium supplementation on exercise and recovery on resistance exercise, blood pressure and total peripheral resistance on normotensive adults. J Int Soc Sports Nutr. 2015;12:19.Kass L.S., Poeira F. The effect of acute vs chronic magnesium supplementation on exercise and recovery on resistance exercise, blood pressure and total peripheral resistance on normotensive adults. J Int Soc Sports Nutr. 2015;12:19.Stendig-Lindberg G. Sudden death of athletes: is it due to long-term changes in serum magnesium, lipids and blood sugar? J Basic Clin Physiol Pharmacol. 1992;3(2):153-164.Stendig-Lindberg G. Sudden death of athletes: is it due to long-term changes in serum magnesium, lipids and blood sugar? J Basic Clin Physiol Pharmacol. 1992;3(2):153-164.Tong T.K., Lin H., Lippi G., Nie J., Tian Y. Serum oxidant and antioxidant status in adolescents undergoing professional endurance sports training. Oxid Med Cell Longev. 2012;2012:741239.Tong T.K., Lin H., Lippi G., Nie J., Tian Y. Serum oxidant and antioxidant status in adolescents undergoing professional endurance sports training. Oxid Med Cell Longev. 2012;2012:741239.Monteiro C.P., Matias C.N., Bicho M., Santa-Clara H., Laires M.J. Coordination between antioxidant defences might be partially modulated by magnesium status. Magnes Res. 2016;29(4):161-168.Monteiro C.P., Matias C.N., Bicho M., Santa-Clara H., Laires M.J. Coordination between antioxidant defences might be partially modulated by magnesium status. Magnes Res. 2016;29(4):161-168.Nikolaidis M.G., Protosygellou M.D., Petridou A., Tsalis G., Tsigilis N., Mougios V. Hematologic and biochemical profile of juvenile and adult athletes of both sexes: implications for clinical evaluation. Int J Sports Med. 2003;24(7):506-511.Nikolaidis M.G., Protosygellou M.D., Petridou A., Tsalis G., Tsigilis N., Mougios V. Hematologic and biochemical profile of juvenile and adult athletes of both sexes: implications for clinical evaluation. Int J Sports Med. 2003;24(7):506-511.Cheng S.M., Yang D.Y., Lee C.P., Pan H.C., Lin M.T., Chen S.H., Cheng F.C. Effects of magnesium sulfate on dynamic changes of brain glucose and its metabolites during a short-term forced swimming in gerbils. Eur J Appl Physiol. 2007;99(6):695-9 Epub 2007 Feb.Cheng S.M., Yang D.Y., Lee C.P., Pan H.C., Lin M.T., Chen S.H., Cheng F.C. Effects of magnesium sulfate on dynamic changes of brain glucose and its metabolites during a short-term forced swimming in gerbils. Eur J Appl Physiol. 2007;99(6):695-9 Epub 2007 Feb.Cheng S.M., Yang L.L., Chen S.H., Hsu M.H., Chen I.J., Cheng F.C. Magnesium sulfate enhances exercise performance and manipulates dynamic changes in peripheral glucose utilization. Eur J Appl Physiol. 2010;108(2):363-9 doi.Cheng S.M., Yang L.L., Chen S.H., Hsu M.H., Chen I.J., Cheng F.C. Magnesium sulfate enhances exercise performance and manipulates dynamic changes in peripheral glucose utilization. Eur J Appl Physiol. 2010;108(2):363-9 doi.Setaro L., Santos-Silva P.R., Nakano E.Y., Sales C.H., Nunes N., Greve J.M., Colli C. Magnesium status and the physical performance of volleyball players: effects of magnesium supplementation. J Sports Sci. 2014;32(5):438-45 doi.Setaro L., Santos-Silva P.R., Nakano E.Y., Sales C.H., Nunes N., Greve J.M., Colli C. Magnesium status and the physical performance of volleyball players: effects of magnesium supplementation. J Sports Sci. 2014;32(5):438-45 doi.Matias C.N., Santos D.A., Monteiro C.P., Vasco A.M., Baptista F., Sardinha L.B., Laires M.J., Silva A.M. Magnesium intake mediates the association between bone mineral density and lean soft tissue in elite swimmers. Magnes Res. 2012;25(3):120-5 doi.Matias C.N., Santos D.A., Monteiro C.P., Vasco A.M., Baptista F., Sardinha L.B., Laires M.J., Silva A.M. Magnesium intake mediates the association between bone mineral density and lean soft tissue in elite swimmers. Magnes Res. 2012;25(3):120-5 doi.Quintas M.E., Ortega R.M., Lopez-Sobaler A.M., Garrido G., Requejo A.M. Influence of dietetic and anthropometric factors and of the type of sport practised on bone density in different groups of women. Eur J Clin Nutr. 2003;57(Suppl 1):S58-S62.Quintas M.E., Ortega R.M., Lopez-Sobaler A.M., Garrido G., Requejo A.M. Influence of dietetic and anthropometric factors and of the type of sport practised on bone density in different groups of women. Eur J Clin Nutr. 2003;57(Suppl 1):S58-S62.Santos D.A., Matias C.N., Monteiro C.P., Silva A.M., Rocha P.M., Minderico C.S., Bettencourt Sardinha L., Laires M.J. Magnesium intake is associated with strength performance in elite basketball, handball and volleyball players. Magnes Res. 2011;24(4):215-9 doi.Santos D.A., Matias C.N., Monteiro C.P., Silva A.M., Rocha P.M., Minderico C.S., Bettencourt Sardinha L., Laires M.J. Magnesium intake is associated with strength performance in elite basketball, handball and volleyball players. Magnes Res. 2011;24(4):215-9 doi.Matias C.N., Santos D.A., Monteiro C.P., Silva A.M., Raposo M. de F., Martins F., Sardinha L.B., Bicho M., Laires M.J. Magnesium and strength in elite judo athletes according to intracellular water changes. Magnes Res. 2010;23(3):138-41 doi.Matias C.N., Santos D.A., Monteiro C.P., Silva A.M., Raposo M. de F., Martins F., Sardinha L.B., Bicho M., Laires M.J. Magnesium and strength in elite judo athletes according to intracellular water changes. Magnes Res. 2010;23(3):138-41 doi.McDonald R., Keen C.L. Iron, zinc and magnesium nutrition and athletic performance. Sports Med. 1988;5(3):171-184.McDonald R., Keen C.L. Iron, zinc and magnesium nutrition and athletic performance. Sports Med. 1988;5(3):171-184.Lukaski H.C., Siders W.A., Hoverson B.S., Gallagher S.K. Iron, copper, magnesium and zinc status as predictors of swimming performance. Int J Sports Med. 1996;17(7):535-540.Lukaski H.C., Siders W.A., Hoverson B.S., Gallagher S.K. Iron, copper, magnesium and zinc status as predictors of swimming performance. Int J Sports Med. 1996;17(7):535-540.Nielsen F.H., Lukaski H.C. Update on the relationship between magnesium and exercise. Magnes Res. 2006;19(3):180-189.Nielsen F.H., Lukaski H.C. Update on the relationship between magnesium and exercise. Magnes Res. 2006;19(3):180-189.Keen C.L., Lowney P., Gershwin M.E., Hurley L.S., Stern J.S. Dietary magnesium intake influences exercise capacity and hematologic parameters in rats. Metabolism. 1987;36(8):788-793.Keen C.L., Lowney P., Gershwin M.E., Hurley L.S., Stern J.S. Dietary magnesium intake influences exercise capacity and hematologic parameters in rats. Metabolism. 1987;36(8):788-793.Макарова Г.А., Граевская Н.Д. Спортивная медицина: Учебник. М.: Советский спорт, 2003. 480 c.Makarova G.A., Graevskaya N.D. Sports medicine: Textbook. M.: Sovetsky Sport, 2003. 480 p. (In Russ).Siegel A.J., Januzzi J., Sluss P., Lee-Lewandrowski E., Wood M., Shirey T., Lewandrowski K.B. Cardiac biomarkers, electrolytes, and other analytes in collapsed marathon runners: implications for the evaluation of runners following competition. Am J Clin Pathol. 2008;129(6):948-51 doi.Siegel A.J., Januzzi J., Sluss P., Lee-Lewandrowski E., Wood M., Shirey T., Lewandrowski K.B. Cardiac biomarkers, electrolytes, and other analytes in collapsed marathon runners: implications for the evaluation of runners following competition. Am J Clin Pathol. 2008;129(6):948-51 doi.Chen Y.J., Chen H.Y., Wang M.F., Hsu M.H., Liang W.M., Cheng F.C. Effects of magnesium on exercise performance and plasma glucose and lactate concentrations in rats using a novel blood-sampling technique. Appl Physiol Nutr Metab. 2009;34(6):1040-7 doi.Chen Y.J., Chen H.Y., Wang M.F., Hsu M.H., Liang W.M., Cheng F.C. Effects of magnesium on exercise performance and plasma glucose and lactate concentrations in rats using a novel blood-sampling technique. Appl Physiol Nutr Metab. 2009;34(6):1040-7 doi.Poleszak E. Modulation of antidepressant-like activity of magnesium by serotonergic system. J Neural Transm (Vienna). 2007;114(9):1129-34 Epub 2007 A.Poleszak E. Modulation of antidepressant-like activity of magnesium by serotonergic system. J Neural Transm (Vienna). 2007;114(9):1129-34 Epub 2007 A.Cardoso C.C., Lobato K.R., Binfare R.W., Ferreira P.K., Rosa A.O., Santos A.R., Rodrigues A.L. Evidence for the involvement of the monoaminergic system in the antidepressant-like effect of magnesium. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33(2):235-42 doi.Cardoso C.C., Lobato K.R., Binfare R.W., Ferreira P.K., Rosa A.O., Santos A.R., Rodrigues A.L. Evidence for the involvement of the monoaminergic system in the antidepressant-like effect of magnesium. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33(2):235-42 doi.Poleszak E., Wlaz P., Kedzierska E., Nieoczym D., Wrobel A., Fidecka S., Pilc A., Nowak G. NMDA/ glutamate mechanism of antidepressant-like action of magnesium in forced swim test in mice. Pharmacol Biochem Behav. 2007;88(2):158-64 Epub 2007 Au.Poleszak E., Wlaz P., Kedzierska E., Nieoczym D., Wrobel A., Fidecka S., Pilc A., Nowak G. NMDA/ glutamate mechanism of antidepressant-like action of magnesium in forced swim test in mice. Pharmacol Biochem Behav. 2007;88(2):158-64 Epub 2007 Au.Delorme O., Bourdin H., Viel J.F., Rigaud M.L., Kantelip J.P. Spectral analysis of electroencephalography data in athletes with low erythrocyte magnesium. Magnes Res. 1992;5(4):261-264.Delorme O., Bourdin H., Viel J.F., Rigaud M.L., Kantelip J.P. Spectral analysis of electroencephalography data in athletes with low erythrocyte magnesium. Magnes Res. 1992;5(4):261-264.Meeusen R., Duclos M., Foster C., Fry A., Gleeson M., Nieman D., Raglin J., Rietjens G., Steinacker J., Urhausen A. Prevention, diagnosis, and treatment of the overtraining syndrome: joint consensus statement of the European College of Sport Science and the American College of Sports Medicine. Med Sci Sports Exerc. 2013;45(1):186-205 doi.Meeusen R., Duclos M., Foster C., Fry A., Gleeson M., Nieman D., Raglin J., Rietjens G., Steinacker J., Urhausen A. Prevention, diagnosis, and treatment of the overtraining syndrome: joint consensus statement of the European College of Sport Science and the American College of Sports Medicine. Med Sci Sports Exerc. 2013;45(1):186-205 doi.Matias C.N., Monteiro C.P., Santos D.A., Martins F., Silva A.M., Laires M.J., Sardinha L.B. Magnesium and phase angle: a prognostic tool for monitoring cellular integrity in judo athletes. Magnes Res. 2015;28(3):92-8 doi.Matias C.N., Monteiro C.P., Santos D.A., Martins F., Silva A.M., Laires M.J., Sardinha L.B. Magnesium and phase angle: a prognostic tool for monitoring cellular integrity in judo athletes. Magnes Res. 2015;28(3):92-8 doi.Silva M.G., Paiva T. Poor precompetitive sleep habits, nutrients’ deficiencies, inappropriate body composition and athletic performance in elite gymnasts. Eur J Sport Sci. 2015;Eur J Spor:1-10.Silva M.G., Paiva T. Poor precompetitive sleep habits, nutrients’ deficiencies, inappropriate body composition and athletic performance in elite gymnasts. Eur J Sport Sci. 2015;Eur J Spor:1-10.Shephard R.J., Shek P.N. Immunological hazards from nutritional imbalance in athletes. Exerc Immunol Rev. 1998;4:22-48.Shephard R.J., Shek P.N. Immunological hazards from nutritional imbalance in athletes. Exerc Immunol Rev. 1998;4:22-48.Laires M.J., Monteiro C. Exercise, magnesium and immune function. Magnes Res. 2008;21(2):92-96.Laires M.J., Monteiro C. Exercise, magnesium and immune function. Magnes Res. 2008;21(2):92-96.Mooren F.C., Golf S.W., Volker K. Effect of magnesium on granulocyte function and on the exercise induced inflammatory response. Magnes Res. 2003;16(1):49-58.Mooren F.C., Golf S.W., Volker K. Effect of magnesium on granulocyte function and on the exercise induced inflammatory response. Magnes Res. 2003;16(1):49-58.Tam M., Gomez S., Gonzalez-Gross M., Marcos A. Possible roles of magnesium on the immune system. Eur J Clin Nutr. 2003;57(10):1193-1197.Tam M., Gomez S., Gonzalez-Gross M., Marcos A. Possible roles of magnesium on the immune system. Eur J Clin Nutr. 2003;57(10):1193-1197.Dmitrasinovic G., Pesic V., Stanic D., PlecasSolarovic B., Dajak M., Ignjatovic S. ACTH, Cortisol and IL-6 Levels in Athletes following Magnesium Supplementation. J Med Biochem. 2016;35(4):375-384.Dmitrasinovic G., Pesic V., Stanic D., PlecasSolarovic B., Dajak M., Ignjatovic S. ACTH, Cortisol and IL-6 Levels in Athletes following Magnesium Supplementation. J Med Biochem. 2016;35(4):375-384.Cordova Martinez A., Fernandez-Lazaro D., Mielgo-Ayuso J., Seco Calvo J., Caballero Garcia A. Effect of magnesium supplementation on muscular damage markers in basketball players during a full season. Magnes Res. 2017;30(2):61-70.Cordova Martinez A., Fernandez-Lazaro D., Mielgo-Ayuso J., Seco Calvo J., Caballero Garcia A. Effect of magnesium supplementation on muscular damage markers in basketball players during a full season. Magnes Res. 2017;30(2):61-70.Petrovic J., Stanic D., Dmitrasinovic G., PlecasSolarovic B., Ignjatovic S., Batinic B., Popovic D., Pesic V. Magnesium Supplementation Diminishes Peripheral Blood Lymphocyte DNA Oxidative Damage in Athletes and Sedentary Young Man. Oxid Med Cell Longev. 2016;2016:2019643.Petrovic J., Stanic D., Dmitrasinovic G., PlecasSolarovic B., Ignjatovic S., Batinic B., Popovic D., Pesic V. Magnesium Supplementation Diminishes Peripheral Blood Lymphocyte DNA Oxidative Damage in Athletes and Sedentary Young Man. Oxid Med Cell Longev. 2016;2016:2019643.Finstad E.W., Newhouse I.J., Lukaski H.C., Mcauliffe J.E., Stewart C.R. The effects of magnesium supplementation on exercise performance. Med Sci Sports Exerc. 2001;33(3):493-498.Finstad E.W., Newhouse I.J., Lukaski H.C., Mcauliffe J.E., Stewart C.R. The effects of magnesium supplementation on exercise performance. Med Sci Sports Exerc. 2001;33(3):493-498.Telford R.D., Catchpole E.A., Deakin V., McLeay A.C., Plank A.W. The effect of 7 to 8 months of vitamin/mineral supplementation on the vitamin and mineral status of athletes. Int J Sport Nutr. 1992;2(2):123-134.Telford R.D., Catchpole E.A., Deakin V., McLeay A.C., Plank A.W. The effect of 7 to 8 months of vitamin/mineral supplementation on the vitamin and mineral status of athletes. Int J Sport Nutr. 1992;2(2):123-134.Ruddel H., Werner C., Ising H. Impact of magnesium supplementation on performance data in young swimmers. Magnes Res. 1990;3(2):103-107.Ruddel H., Werner C., Ising H. Impact of magnesium supplementation on performance data in young swimmers. Magnes Res. 1990;3(2):103-107.Громова О.А., Торшин И.Ю., Кобалава Ж.Д., Сорокина М.А. О фундаментальных и клинических аспектах синергидного действия магния и рибофлавина в терапевтической практике. Терапия. 2018; 19(1): 119–131.Gromova O.A., Torshin I.Yu., Kobalava J.D., Sorokina M.A. On the fundamental and clinical aspects of the synergistic action of magnesium and riboflavin in therapeutic practice. Terapia. 2018; 19 (1): 119–131. (In Russ).Masui T., Staple E. The formation of bile acids from cholesterol. The conversion of 5-betacholestane-3-alpha,7-alpha-triol-26-oic acid to cholic acid via 5-beta-cholestane-3-alpha,7alpha,12-alpha, 24-xi-tetraol-26-oic acid I by rat liver. J Biol Chem. 1966;241(17):3889-3893.Masui T., Staple E. The formation of bile acids from cholesterol. The conversion of 5-betacholestane-3-alpha,7-alpha-triol-26-oic acid to cholic acid via 5-beta-cholestane-3-alpha,7alpha,12-alpha, 24-xi-tetraol-26-oic acid I by rat liver. J Biol Chem. 1966;241(17):3889-3893.Harris S.C., Ivy A.C., Friedemann T.E. Work at high altitude; the effect of training and dietary restriction of thiamin and riboflavin on altitude tolerance and physical efficiency for work at a simulated altitude of 15,000 feet. Q Bull Northwest Univ Med Sch. 1947;21(2):135-151.Harris S.C., Ivy A.C., Friedemann T.E. Work at high altitude; the effect of training and dietary restriction of thiamin and riboflavin on altitude tolerance and physical efficiency for work at a simulated altitude of 15,000 feet. Q Bull Northwest Univ Med Sch. 1947;21(2):135-151.Du W., Wang H., Chen S., Su C., Zhang H., Zhang B. Trend of dietary nutrient intake among adult females in 9 provinces in China, 2000-2011. Zhonghua Liu Xing Bing Xue Za Zhi. 2015;36(7):715-719.Du W., Wang H., Chen S., Su C., Zhang H., Zhang B. Trend of dietary nutrient intake among adult females in 9 provinces in China, 2000-2011. Zhonghua Liu Xing Bing Xue Za Zhi. 2015;36(7):715-719.Touvier M., Lioret S., Vanrullen I., Bocle J.C., Boutron-Ruault M.C., Berta J.L., Volatier J.L. Vitamin and mineral inadequacy in the French population: estimation and application for the optimization of food fortification. Int J Vitam Nutr Res. 2006;76(6):343-351.Touvier M., Lioret S., Vanrullen I., Bocle J.C., Boutron-Ruault M.C., Berta J.L., Volatier J.L. Vitamin and mineral inadequacy in the French population: estimation and application for the optimization of food fortification. Int J Vitam Nutr Res. 2006;76(6):343-351.Manore M.M. Effect of physical activity on thiamine, riboflavin, and vitamin B-6 requirements. Am J Clin Nutr. 2000;72(2 Suppl:598S-606S.Manore M.M. Effect of physical activity on thiamine, riboflavin, and vitamin B-6 requirements. Am J Clin Nutr. 2000;72(2 Suppl:598S-606S.Beketova N.A., Kosheleva O.V., Pereverzeva O.G., Vrzhesinskaia O.A., Kodentsova V.M., Solntseva T.N., Khanfer’ian R.A. Vitamin-antioxidant sufficiency of winter sports athletes. Vopr Pitan. 2013;82(6):49-57.Beketova N.A., Kosheleva O.V., Pereverzeva O.G., Vrzhesinskaia O.A., Kodentsova V.M., Solntseva T.N., Khanfer’ian R.A. Vitamin-antioxidant sufficiency of winter sports athletes. Vopr Pitan. 2013;82(6):49-57.Rakhmanov R.S., Kuznetsova L.V., Blinova T.V., Strakhova L.A., Tsariapkin V.E. Vitamin and mineral status of oarsmen during the training-competition cycles. Vopr Pitan. 2013;82(4):76-81.Rakhmanov R.S., Kuznetsova L.V., Blinova T.V., Strakhova L.A., Tsariapkin V.E. Vitamin and mineral status of oarsmen during the training-competition cycles. Vopr Pitan. 2013;82(4):76-81.Diaz E., Ruiz F., Hoyos I., Zubero J., Gravina L., Gil J., Irazusta J., Gil S.M. Cell damage, antioxidant status, and cortisol levels related to nutrition in ski mountaineering during a two-day race. J Sports Sci Med. 2010;9(2):338-46 eCollection.Diaz E., Ruiz F., Hoyos I., Zubero J., Gravina L., Gil J., Irazusta J., Gil S.M. Cell damage, antioxidant status, and cortisol levels related to nutrition in ski mountaineering during a two-day race. J Sports Sci Med. 2010;9(2):338-46 eCollection.Prakhin E.I., Evert L.S., Iakushina L.M. Effects of prophylactic vitamin administration of physical fitness of schoolchildren in the Arctic Regions. Vopr Pitan. 1992;(3):53-58.Prakhin E.I., Evert L.S., Iakushina L.M. Effects of prophylactic vitamin administration of physical fitness of schoolchildren in the Arctic Regions. Vopr Pitan. 1992;(3):53-58.Suboticanec K., Stavljenic A., Schalch W., Buzina R.. Effects of pyridoxine and riboflavin supplementation on physical fitness in young adolescents. Int J Vitam Nutr Res. 1990;60(1):81-88.Suboticanec K., Stavljenic A., Schalch W., Buzina R.. Effects of pyridoxine and riboflavin supplementation on physical fitness in young adolescents. Int J Vitam Nutr Res. 1990;60(1):81-88.Hoffman M.D., Valentino T.R., Stuempfle K.J., Hassid B.V. A Placebo-Controlled Trial of Riboflavin for Enhancement of Ultramarathon Recovery. Sports Med Open. 2017;3(1):14.Hoffman M.D., Valentino T.R., Stuempfle K.J., Hassid B.V. A Placebo-Controlled Trial of Riboflavin for Enhancement of Ultramarathon Recovery. Sports Med Open. 2017;3(1):14.

The authors declare that there are no conflicts of interest present.