medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2019-2-173-182medsovet-2873Research ArticleАЛЛЕРГОЛОГИЯ И ИММУНОЛОГИЯALLERGOLOGY AND IMMUNOLOGYПробиотики при респираторных заболеваниях: есть ли пути взаимодействия и перспективы применения?Probiotics in the management of respiratory diseases: ways of interaction and therapeutic perspectivesЗахароваИ. Н.ZakharovaI. N.

Захарова Ирина Николаевна – заслуженный врач РФ, доктор медицинских наук, профессор, заведующая кафедрой педиатрии с курсом поликлинической педиатрии им. Г.Н. Сперанского

125993, г. Москва, ул. Баррикадная, д. 2/1, стр. 1

Zakharova Irina Nikolaevna – Honoured Doctor of RF, Dr. of Sci. (Med.), Professor, Speransky Chair of Paediatrics with Course of Polyclinic Paediatrics

125993, Moscow, Barrikadnaya St., 2/1, b. 1

zakharovarmapo@yandex.ruБережнаяИ. В.BerezhnayaI. V.

Бережная Ирина Владимировна – кандидат медицинских наук, доцент кафедры с курсом поликлинической педиатрии имени академика Г.Н. Сперанского

125993, г. Москва, ул. Баррикадная, д. 2/1, стр. 1

Berezhnaya Irina Vladimirovna – Cand. of Sci. (Med.), Assistant Professor, Speransky Chair of Paediatrics with Course of Polyclinic Paediatrics

125993, Moscow, Barrikadnaya St., 2/1, b. 1

berezhnaya-irina26@yandex.ruКлимовЛ. Я.KlimovL. Ya.

Климов Леонид Яковлевич – кандидат медицинских наук, доцент, заведующий кафедрой педиатрии

355017, Ставропольский край, г. Ставрополь, ул. Мира, д. 310

Klimov Leonid Yakovlevich – Cand.of Sci. (Med.), Associate Professor, Head of the Chair of Intermediate Level Paediatrics

355017, Stavropol Krai, Stavropol, Mira Str., 310

klimov_leo@mail.ruКасьяноваА. Н.KasyanovaA. N.

Касьянова Анна Николаевна – клинический ординатор кафедры педиатрии с курсом поликлинической педиатрии имени академика Г.Н. Сперанского

125993, г. Москва, ул. Баррикадная, д. 2/1, стр. 1

Kasyanova Anna Nikolaevna – a resident physician, Speransky Chair of Paediatrics with Course of Polyclinic Paediatrics

125993, Moscow, Barrikadnaya St., 2/1, b. 1

a.nicolaevnakasjanova@yandex.ruДедиковаО. В.DedikovaO. V.

Дедикова Ольга Валерьевна – клинический ординатор кафедры педиатрии с курсом поликлинической педиатрии имени академика Г.Н. Сперанского

125993, г. Москва, ул. Баррикадная, д. 2/1, стр. 1

Dedikova Olga Valeryevna – a resident physician, Speransky Chair of Paediatrics with Course of Polyclinic Paediatrics

125993, Moscow, Barrikadnaya St., 2/1, b. 1

olga.dedikova74@yandex.ruКольцовК. А.KoltsovK. A.

Кольцов Константин Анатольевич – соискатель кафедры педиатрии с курсом поликлинической педиатрии им. Г.Н. Сперанского

125993, г. Москва, ул. Баррикадная, д. 2/1, стр. 1

Koltsov Konstantin Anatolyevich – a doctoral student, Speransky Chair of Paediatrics with Course of Polyclinic Paediatrics

125993, Moscow, Barrikadnaya St., 2/1, b. 1

kkoltsov@gmail.comФедеральное государственное бюджетное образовательное учреждение дополнительного профессионального образования «Российская медицинская академия непрерывного профессионального образования» Министерства здравоохранения Российской ФедерацииРоссияFederal State Budgetary Educational Institution of Additional Professional Education «Russian Medical Academy of Continuing Professional Education» of the Ministry of Health of the Russian FederationRussian FederationФедеральное государственное бюджетное образовательное учреждение высшего образования «Ставропольский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияFederal State Budgetary Educational Institution of Higher Education «Stavropol State Medical University» of the Ministry of Health of the Russian FederationRussian Federation20191502201902173182Copyright © Захарова И.Н., Бережная И.В., Климов Л.Я., Касьянова А.Н., Дедикова О.В., Кольцов К.А., 20192019Захарова И.Н., Бережная И.В., Климов Л.Я., Касьянова А.Н., Дедикова О.В., Кольцов К.А.Zakharova I.N., Berezhnaya I.V., Klimov L.Y., Kasyanova A.N., Dedikova O.V., Koltsov K.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/2873

На сегодняшний день достаточно подробно изучен состав микробиома желудочно-кишечного тракта. Появляется все больше исследований о наличии в респираторном тракте, как в верхних, так и нижних дыхательных путях, своего собственного микробиома. В статье представлены основные известные на сегодняшний день сведения о видовом разнообразии микроорганизмов, присутствующих в респираторном и желудочно-кишечном трактах, описана роль здорового микробиома в обеспечении местного и общего иммунитета. Описана роль пробиотических штаммов микроорганизмов и их влияние на различные звенья иммунного ответа. Представлены данные исследований по изучению влияния пробиотических препаратов на обеспечение иммунологической резистентности организма человека, особенно респираторного тракта при высокой вирусной нагрузке. Восстановление нормального микробиома в организме человека с использованием пробиотических препаратов, вводимых через ЖКТ, способно снизить риски развития респираторных инфекционных заболеваний и тяжесть их проявления.

Today, the composition of the gut microbiota has been studied in sufficient detail. Increasing number of studies show that the respiratory tract, both the upper and lower respiratory tract, have their own microbiota. The article presents the main today’s data about the species diversity of microorganisms in the respiratory and gastrointestinal tracts, describes the role of a healthy microbiota in providing local and general immunity. The authors specify the role of probiotic strains of microorganisms and their effect on various parts of the immune response and present the data of studies on the effect of probiotic products on the immunological resistance of humans, especially the respiratory tract with high viral load. Restoration of a healthy microbiota in the human tract using probiotic products administered through the gastrointestinal tract can reduce the risk and severity of manifestation of the respiratory infections.

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The authors declare that there are no conflicts of interest present.