medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2019-1-24-30medsovet-2894Research ArticleЦЕРЕБРОВАСКУЛЯРНЫЕ ЗАБОЛЕВАНИЯCEREBROVASCULAR DISEASESПатофизиологические особенности хронических цереброваскулярных заболеваний и возможности комплексной нейропротективной терапииPathophysiological features of chronic cerebrovascular diseases and possibilities of complex neuroprotective therapyКостенкоЕ. В.KostenkoE. V.

д.м.н., профессор кафедры неврологии, медицинской генетики и нейрохирургии Федерального государственного бюджетного образовательного учреждения высшего образования «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Министерства здравоохранения Россий ской Федерации, ведущий научный сотрудник, заведующая филиалом №7 Государственного автономного учреждения здравоохранения города Москвы «Московский научно-практический центр медицинской реабилитации, восстановительной и спортивной медицины Департамента здравоохранения города Москвы»

Dr. of Sci. (Med.)., Professor of Chair of Neurology, Medical Genetics and Neurosurgery, Federal State Budgetary Educational Institution of Higher Education «Pirogov Russian National Research Medical University» of the Ministry of Health of the Russian Federation, a lead researcher, Head of Branch 7 of Moscow Autonomous Healthcare Institution “Moscow State Autonomous Healthcare Institution «Moscow Scientific and Practical Centre of Medical Rehabilitation, Restorative and Sports Medicine of Moscow Health Care Department»

ekostenko58@mail.ruПетроваЛ. В.PetrovaL. V.

к.м.н., заведующая отделением филиала №7 Государственного автономного учреждения здравоохранения города Москвы «Московский научно-практический центр медицинской реабилитации, восстановительной и спортивной медицины Департамента здравоохранения города Москвы»

Cand. of Sci. (Med.), Head of Branch 7 of Moscow Autonomous Healthcare Institution «Moscow Scientific and Practical Centre of Medical Rehabilitation, Restorative and Sports Medicine of Moscow Health Care Department»

ludmila.v.petrova@yandex.ruГосударственное автономное учреждение здравоохранения города Москвы «Московский научно-практический центр медицинской реабилитации, восстановительной и спортивной медицины Департамента здравоохранения города Москвы»; Федеральное государственное бюджетное образовательное учреждение высшего образования «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Министерства здравоохранения Российской ФедерацииРоссияMoscow State Autonomous Healthcare Institution «Moscow Scientific and Practical Centre of Medical Rehabilitation, Restorative and Sports Medicine of Moscow Health Care Department»; Federal State Budgetary Educational Institution of Higher Education «Pirogov Russian National Research Medical University» of the Ministry of Health of RussiaRussian FederationГосударственное автономное учреждение здравоохранения города Москвы «Московский научно-практический центр медицинской реабилитации, восстановительной и спортивной медицины Департамента здравоохранения города Москвы»РоссияMoscow State Autonomous Healthcare Institution «Moscow Scientific and Practical Centre of Medical Rehabilitation, Restorative and Sports Medicine of Moscow Health Care Department»Russian Federation201905032019012430Copyright © Костенко Е.В., Петрова Л.В., 20192019Костенко Е.В., Петрова Л.В.Kostenko E.V., Petrova L.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/2894

В статье обсуждаются принципы нейропротективной терапии как патофизиологически обоснованного направления при хронических цереброваскулярных заболеваниях (ХЦВЗ). Представлен обзор исследований, доказывающих эффективность и высокий профиль безопасности мощного антиоксиданта идебенона (Нейромет), а также отечественного цитопротектора холина альфосцерата (Церепро®), влияющих на основные патофизиологические процессы ишемического каскада при ХЦВЗ. Подчеркнута роль рациональной мультимодальной фармакотерапии ХЦВЗ, которая позволяет обеспечить необходимой энергией процессы нейропротекции и нейропластичности клеток мозга.

 

The article discusses the principles of neuroprotective therapy as a pathogenetically justified direction in chronic cerebrovascular diseases (CVD). The results of numerous clinical trials demonstrated efficacy, safety, a wide range of pharmacological effects and good tolerability of the powerful antioxidant Idebenone (Neyromet), as well as domestic cytoprotector, Choline alphosceratus of (Cerepro®), affecting the basic pathophysiological processes of the ischemic cascade at CVD. The role of rational multimodal pharmacotherapy of CVD, which provides the necessary energy for the processes of neuroprotection and neuroplasticity of brain cells, is emphasized.

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The authors declare that there are no conflicts of interest present.