medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2019-1-33-38medsovet-2895Research ArticleНЕРВНО-ПСИХИЧЕСКИЕ РАССТРОЙСТВАNEUROPSYCHIATRIC DISORDERSХронобиологические особенности первичных головных болей и роль мелатонина в регуляции биологических ритмовChronobiological features of primary headaches and the role of melatonin in the regulation of biological rhythmsЕвдокимоваЕ. М.EvdokimovaE. M.

врачневролог, аспирант кафедры нервных болезней и нейрохирургии лечебного факультета Федерального государственного автономного образовательного учреждения высшего образования «Первый Московский государственный медицинский университет имени И.М. Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский университет)

neurologist, postgraduate student, Chair of Nervous Diseases and Neurosurgery at the Faculty of General Medicine, Federal State Autonomous Educational Institution of Higher Education «I.M. Sechenov First Moscow State Medical University» of the Ministry of Heath of the Russian Federation (Sechenov University)

chernovalm@inbox.ruПолуэктовМ. Г.PoluektovM. G.

доцент кафедры нервных болезней и нейрохирургии лечебного факультета Федерального государственного автономного образовательного учреждения высшего образования «Первый Московский государственный медицинский университет имени И.М. Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский университет)

neurologist, Associate Professor, Chair of Nervous Diseases and Neurosurgery at the Faculty of General Medicine, Federal State Autonomous Educational of Higher Education «I.M. Sechenov First Moscow State Medical University» of the Ministry of Heath of the Russian Federation (Sechenov University)

polouekt@mail.ruТабееваГ. Р.TabeyevaG. R.

д.м.н., профессор кафедры нервных болезней и нейрохирургии лечебного факультета Федерального государственного автономного образовательного учреждения высшего образования «Первый Московский государственный медицинский университет имени И.М. Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский университет)

Dr. of Sci. (Med.), Professor, Chair of Nervous Diseases and Neurosurgery at the Faculty of General Medicine, Federal State Autonomous Educational of Higher Education «I.M. Sechenov First Moscow State Medical University» of the Ministry of Heath of the Russian Federation (Sechenov University)

grtabeeva@gmail.comФедеральное государственное автономное образовательное учреждение высшего образования «Первый Московский государственный медицинский университет имени И.М. Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский университет)РоссияFederal State Autonomous Educational Institution of Higher Education «I.M. Sechenov First Moscow State Medical University» of the Ministry of Heath of the Russian Federation (Sechenov University)Russian Federation201905032019013338Copyright © Евдокимова Е.М., Полуэктов М.Г., Табеева Г.Р., 20192019Евдокимова Е.М., Полуэктов М.Г., Табеева Г.Р.Evdokimova E.M., Poluektov M.G., Tabeyeva G.R.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/2895

Периодичность рассматривается как ключевой признак течения некоторых форм первичных головных болей (ПГБ). Одними из наиболее ярких представителей является гипническая и кластерная головная боль, что и предопределило их название. Клинические наблюдения демонстрируют четкий циркадианный суточный и сезонный паттерн пучковой головной боли и приступов мигрени. В соответствии с современными представлениями феномен периодичности болевых эпизодов ряда форм первичных головных болей связывают с дисфункцией супрахиазменного ядра гипоталамуса, являющегося главным пейсмейкером биологических ритмов – «эндогенными часами». Связь ПГБ с хронопатологией подтверждается и нарушением секреции мелатонина, обнаруженной при мигрени и пучковой головной боли. Применение препаратов мелатонина при этих формах ПГБ оказывается эффективным.

Frequency is considered as a key sign of the course of some forms of primary headaches (PH). One of the most prominent representatives is the hypnical and cluster headache, which predetermined their name. Clinical observations demonstrate a clear circadian rhythm and seasonal pattern of cluster headache (CH) and migraine (M) attacks. In accordance with modern concepts, the phenomenon of the periodicity of painful episodes of a number of forms of primary headaches is associated with dysfunction of the suprachiasmatic nucleus of the hypothalamus, the main pacemaker of biological rhythms. The connection of PH with chronopathology is confirmed by revealing the disturbances of melatonin secretion in CH and M. Melatonin has proven to be effective in treatment of these PH.

первичные головные болимигренькластерная головная больголовная боль напряжениямелатонинбиологические ритмыхронобиологияprimary headachesmigrainecluster headachetension type headachemelatoninbiological rhythmschronobiologyReferencesHalberg F. Chronobiology. Annual review of Physiology. 1969;31:675-725.Halberg F. Chronobiology. Annual review of Physiology. 1969;31:675-725.Foster R., Kretzman L. Rhythms of Life: The biological clocks That Control the Daily Lives of Every Living Thing. London; Profile, 2004.Foster R., Kretzman L. Rhythms of Life: The biological clocks That Control the Daily Lives of Every Living Thing. London; Profile, 2004.Refinetti R. Circadian physiology. New York, USA; Taylor and Francis, 2006.Refinetti R. Circadian physiology. New York, USA; Taylor and Francis, 2006.Baumel B., Eisner L.B. Diagnosis and treatment of headache in the elderly. Med. Clin. North Am. 1991;75:575-616.Baumel B., Eisner L.B. Diagnosis and treatment of headache in the elderly. Med. Clin. North Am. 1991;75:575-616.Barloese M., Jennum P., Lund N., Jensen R.H. Sleep in cluster headache, beyond a temporal REM-relationship? European Journal of Neurology. 2015;22:656–664.Barloese M., Jennum P., Lund N., Jensen R.H. Sleep in cluster headache, beyond a temporal REM-relationship? European Journal of Neurology. 2015;22:656–664.Terzaghi M., Ghiotto N., Sances G., Rustioni V., Nappi G., Manni R. Episodic cluster headache: NREM prevalence of nocturnal attacks Time to look beyond macrostructural analysis? Headache. 2010;50(6):1050–1054.Terzaghi M., Ghiotto N., Sances G., Rustioni V., Nappi G., Manni R. Episodic cluster headache: NREM prevalence of nocturnal attacks Time to look beyond macrostructural analysis? Headache. 2010;50(6):1050–1054.Фокин И.В. Клинико-психологическая характеристика и церебральные патогенетические механизмы кластерной головной боли: дис. … канд. мед. наук. М., 2000. 148 с.Fokin I.V. Clinical and psychological characteristics and cerebral pathogenetic mechanisms of cluster headache: Cand. of Sci. (Med.) Dissertation. M., 2000. 148 p. (In Russ).Manzoni G.C., Bono G., Lanfranchi M., Micieli G., Terzano M.G. & Nappi G. Lithium carbonate in cluster headache: assessment of its short term and long term therapeutic efficacy. Cephalgia. 1983;3(2):109-114.Manzoni G.C., Bono G., Lanfranchi M., Micieli G., Terzano M.G. & Nappi G. Lithium carbonate in cluster headache: assessment of its short term and long term therapeutic efficacy. Cephalgia. 1983;3(2):109-114.Barloese M., Lund N., Jensen R.H. Sleep in trigeminal autonomic cephalagias: A review. Cephalalgia. 2014;34(10):813–822.Barloese M., Lund N., Jensen R.H. Sleep in trigeminal autonomic cephalagias: A review. Cephalalgia. 2014;34(10):813–822.Rozen T.D., Fishman R.S. Cluster headache in the United States of America: Demographics, clinical characteristics, triggers, suicidality, and personal burden. Headache. 2011;52: 99–113.Rozen T.D., Fishman R.S. Cluster headache in the United States of America: Demographics, clinical characteristics, triggers, suicidality, and personal burden. Headache. 2011;52: 99–113.Ofte H.K., Berg D.H., Bekkelund S.I., Alstadhaug K.B. Insomnia and periodicity of headache in an Arctic cluster headache population. Headache. 2013;53:1602–1612.Ofte H.K., Berg D.H., Bekkelund S.I., Alstadhaug K.B. Insomnia and periodicity of headache in an Arctic cluster headache population. Headache. 2013;53:1602–1612.Manzoni G.C., Terzano M.G., Bono G. Cluster headache – clinical findings in 180 patients. Cephalalgia. 1983, 3: 21–30.Manzoni G.C., Terzano M.G., Bono G. Cluster headache – clinical findings in 180 patients. Cephalalgia. 1983, 3: 21–30.Ferrari E., Canepari C., Bossolo P.A..Changes of biological rhythms in primary headache syndromes. Cephalalgia, 1983;3(1):58–68.Ferrari E., Canepari C., Bossolo P.A..Changes of biological rhythms in primary headache syndromes. Cephalalgia, 1983;3(1):58–68.Leone M., D’Amico D., Moschiano F., Fraschini F., Bussone G. Melatonin versus placebo in the prophylaxis of cluster headache: A doubleblind pilot study with parallel groups. Cephalalgia. 1996;16(7):494–496.Leone M., D’Amico D., Moschiano F., Fraschini F., Bussone G. Melatonin versus placebo in the prophylaxis of cluster headache: A doubleblind pilot study with parallel groups. Cephalalgia. 1996;16(7):494–496.Kudrow L. The cyclic relationship of natural illumination to cluster period frequency. Cephalalgia. 1987;7(6):76–82.Kudrow L. The cyclic relationship of natural illumination to cluster period frequency. Cephalalgia. 1987;7(6):76–82.Алексеев В.В. Хронические головные боли. Клиника, диагностика, патогенез: автореф. дис. … д-ра мед. наук. М., 2006.Alexeev V.V. Chronic headaches. Clinical manifestations, diagnosis, pathogenesis: extended abstract of Dr. of Sci. (Med.) Dissertation. M., 2006. (In Russ).Осипова В.В. Головная боль напряжения: практическое руководство для врачей. М.: ООО «ОГГИ. Рекламная продукция», 2009. 44 с.Osipova V.V. Tension headache: a practical guide for physicians. M.: OGGI. Reklamnaya Produktsiya, LLC, 2009. 44 p. (In Russ).Bruera O., Sances G., Leston J., Levin G., Cristina S., Medina C. Plasma melatonin pattern in chronic and episodic headaches. Evaluation during sleep and waking. Functional Neurology. 2008;23(2):77-81.Bruera O., Sances G., Leston J., Levin G., Cristina S., Medina C. Plasma melatonin pattern in chronic and episodic headaches. Evaluation during sleep and waking. Functional Neurology. 2008;23(2):77-81.Осипова В.В., Левин Я.И. Мигрень в цикле сон-бодрствование. Журнал неврологии и психиатрии им. С.С. Корсакова. 2006;106(5): 9-15.Osipova V.V., Levin Ya.I. Migraine in the sleepwake cycle. Zhurnal Nevrologii i Psikhiatrii Im. S.S. Korsakova. 2006;106(5):9-15. (In Russ).Dexter J.D., Riley T.L. Studies in nocturnal migraine. Headache. 1975;15(1):51-62.Dexter J.D., Riley T.L. Studies in nocturnal migraine. Headache. 1975;15(1):51-62.Gori S., Morelli N., Maestri M., Fabbrini M., Bonanni E., Murri L. Sleep quality, chronotypes and preferential timing of attacks in migraine without aura. J. Headache Pain.2005;6:258-260.Gori S., Morelli N., Maestri M., Fabbrini M., Bonanni E., Murri L. Sleep quality, chronotypes and preferential timing of attacks in migraine without aura. J. Headache Pain.2005;6:258-260.Solomon G.D. Circadian rhythms and migraine. Cleve Clin J Med. 1992;59:326-329.Solomon G.D. Circadian rhythms and migraine. Cleve Clin J Med. 1992;59:326-329.Fox AW., Davies R.L. Migraine chronobioilogy. Headache. 1998;38:436-441.Fox AW., Davies R.L. Migraine chronobioilogy. Headache. 1998;38:436-441.Gori S., Lucchesi C., Baldacci F., Bonuccelli U. Preferential occurrence of attacks during night sleep and/or upon awakening negatively affects migraine clinical presentation. Funct Neurol. 2015;30(2):119-123.Gori S., Lucchesi C., Baldacci F., Bonuccelli U. Preferential occurrence of attacks during night sleep and/or upon awakening negatively affects migraine clinical presentation. Funct Neurol. 2015;30(2):119-123.Alstadhaug K.B., Salvesen R., Bekkelung S. 24-hour distribution of migraine. Headache. 2008;48:95-100.Alstadhaug K.B., Salvesen R., Bekkelung S. 24-hour distribution of migraine. Headache. 2008;48:95-100.Soriani S., Fiumana E., Manfredini R., Boari B., Battistella PA., Canetta E. et al. Circadian and seasonal variation of migraine attacks in children. Headache. 2006;46:1571-1574.Soriani S., Fiumana E., Manfredini R., Boari B., Battistella PA., Canetta E. et al. Circadian and seasonal variation of migraine attacks in children. Headache. 2006;46:1571-1574.Осипова В.В., Табеева Г.Р. Первичные головные боли: диагностика, клиника, терапия. Практическое руководство. М.: ООО «Издательство «Медицинское информационное агентство», 2014. 336 с.Osipova V.V., Tabeeva G.R. Primary headaches: diagnosis, clinic manifestations, therapy. A practical guide. M.: Izdatelstvo “Meditsinskoye Informatsionnoye Agentstvo”, LLC, 2014. 336 p. (In Russ).Torelli P., Cologno D., Manzoni G.C. Weekend headache: A possible role of work and lifestyle. Headache. 1999;39:398-408.Torelli P., Cologno D., Manzoni G.C. Weekend headache: A possible role of work and lifestyle. Headache. 1999;39:398-408.Cugini P., Romit A., Di Palma L., Giacovazzo M. Common migraine as weekly and seasonal headache. Chronobiology International. 1990;7:467-469.Cugini P., Romit A., Di Palma L., Giacovazzo M. Common migraine as weekly and seasonal headache. Chronobiology International. 1990;7:467-469.Hoffmann J., Lo H., Neeb L., Martus P., Reuter U. Weather sensitivity in migraineurs. J. Neurol. 2011;258(4):596-602.Hoffmann J., Lo H., Neeb L., Martus P., Reuter U. Weather sensitivity in migraineurs. J. Neurol. 2011;258(4):596-602.Alstadhaug K.B., Salvesen R., Bekkelung S.I. Seasonal variation in migraine. Cephalalgia. 2005;25:811-816.Alstadhaug K.B., Salvesen R., Bekkelung S.I. Seasonal variation in migraine. Cephalalgia. 2005;25:811-816.Headache Classification Committee of the International Headache Society The International Classification of Headache Disorders. 3rd ed (beta version). Cephalalgia. 2013;33(9):629–808.Headache Classification Committee of the International Headache Society The International Classification of Headache Disorders. 3rd ed (beta version). Cephalalgia. 2013;33(9):629–808.Deshumuk V.D. Retino-hypothalamic-pineal hypothesis in the pathophysiology of primary headaches. Medical Hypothesis. 2006;66:1146-1151.Deshumuk V.D. Retino-hypothalamic-pineal hypothesis in the pathophysiology of primary headaches. Medical Hypothesis. 2006;66:1146-1151.Peres M.F., Sanchez del Rio M., Seabra M.L., Tufik S., Abucham J., Cipolla-Neto J. et al. Hypothalamic involvement in chronic migraine. J Neurol Neurosurg Psychiatry. 2001;71(6):747-51.Peres M.F., Sanchez del Rio M., Seabra M.L., Tufik S., Abucham J., Cipolla-Neto J. et al. Hypothalamic involvement in chronic migraine. J Neurol Neurosurg Psychiatry. 2001;71(6):747-51.Ong J.C., Taylor H.L., Park M., Burgess H.J., Fox R.S., Snyder S. et al. Can Circadian Dysregulation Exacerbate Migraines? Headache. 2018;58(7):1040-1051.Ong J.C., Taylor H.L., Park M., Burgess H.J., Fox R.S., Snyder S. et al. Can Circadian Dysregulation Exacerbate Migraines? Headache. 2018;58(7):1040-1051.Brennan K.C, Bates E.A., Shapiro R.E., Zyuzin J., Hallows W.C., Huang Y. Casein kinase iδ mutations in familial migraine and advanced sleep phase. Sci Transl Med., 2013;5:183ra56,1-183ra56,11.Brennan K.C, Bates E.A., Shapiro R.E., Zyuzin J., Hallows W.C., Huang Y. Casein kinase iδ mutations in familial migraine and advanced sleep phase. Sci Transl Med., 2013;5:183ra56,1-183ra56,11.Rivas-Martínez I., Ambite-Quesada S., Fernández-de-las-Peñas C., Arroyo-Morales M., Fernández-Mayoralas D.M., Linares-García-Valdecasas R. et al. Salivary cortisol and melatonin levels in children with frequent episodic tension-type headache do not differ from healthy children. Acta Paediatr. 2011;100(11):198-202.Rivas-Martínez I., Ambite-Quesada S., Fernández-de-las-Peñas C., Arroyo-Morales M., Fernández-Mayoralas D.M., Linares-García-Valdecasas R. et al. Salivary cortisol and melatonin levels in children with frequent episodic tension-type headache do not differ from healthy children. Acta Paediatr. 2011;100(11):198-202.Nagtegaal J.E., Smits M.G., Swart A.C., Kerkhof G.A., van der Meer YG. Melatonin-responsive headache in delayed sleep phase syndrome: preliminary observations. Headache. 1998;38(4):303-309.Nagtegaal J.E., Smits M.G., Swart A.C., Kerkhof G.A., van der Meer YG. Melatonin-responsive headache in delayed sleep phase syndrome: preliminary observations. Headache. 1998;38(4):303-309.Pacheco L.R., Latorraca de O.C.C, Freitas da Costa A.L.A, Martimbianco L.C.A, Pachito VD, Riera R. Melatonin for preventing primary headache: A systematic review. Int J Clin Pract. 2018;72(7):132-135.Pacheco L.R., Latorraca de O.C.C, Freitas da Costa A.L.A, Martimbianco L.C.A, Pachito VD, Riera R. Melatonin for preventing primary headache: A systematic review. Int J Clin Pract. 2018;72(7):132-135.Курганова Ю.М., Данилов А.Б. Мелатонин при боли в спине и предикторы его эффективности. Журнал неврологии и психиатрии им. С.С. Корсакова. 2017;117(10):49-54.Kurganova Yu.M., Danilov A.B. Melatonin in back pain and predictors of melatonin efficacy. Zhurnal Nevrologii i Psikhiatrii Im. S.S. Korsakova. 2017;117(10):49-54. (In Russ).

The authors declare that there are no conflicts of interest present.