References

medsovet

Медицинский Совет

Meditsinskiy sovet = Medical Council

2079-701X2658-5790

REMEDIUM GROUP Ltd.

10.21518/2079-701X-2016-1-1-16

medsovet-29

Research Article

ДИССЕРТАНТ

DISSERTANT

Лечение острого лимфобластного лейкоза у детей. Обзор литературы

Treatment of acute lymphoblastic leukemia in children: a review of literature

Алескерова

Г. А.

Aleskerova

G. A.

noemail@neicon.ru

НИИ детской онкологии и гематологииРоссияInstitute of Pediatric Oncology and Hematology of the N. N. BlokhinRussian Federation

2016

30122016

11172178

2016

Алескерова Г.А.

Aleskerova G.A.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.med-sovet.pro/jour/article/view/29

В статье представлены основные этапы совершенствования программ лечения острого лимфо-бластного лейкоза (ОЛЛ) у детей от монотерапии преднизолоном и 6-меркаптопурином до современных многокомпонентных риск-адаптированных протоколов полихимиотерапии. Отдельное внимание уделено анализу факторов риска, которые менялись по мере расширения представлений о молекулярно-биологических особенностях ОЛЛ. Только детальный анализ клинических и иммунобиологических характеристик ОЛЛ позволил разработать современные высокоэффективные программы лечения, позволяющие получить выздоровления более чем у 80% больных.

The article tells about the main stages of improving treatment regimens for acute lymphoblastic leukemia (ALL) in children, from monotherapy with prednisolone and 6-mercaptopurine to novel multicomponent risk-adapted chemotherapy protocols. The focus is on evaluating risk factors which varied with the expansion of knowledge about the molecular biological profile of ALL. Only the detailed analysis of the clinical and immunobiological characteristics of ALL allowed to develop novel, highly effective treatment schemes leading to recovery in over 80% of patients.

острый лимфобластный лейкозлечениедетиacute lymphoblastic leukemiatreatmentchildren

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The authors declare that there are no conflicts of interest present.