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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2019-1-84-87</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-2903</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ДИССЕРТАНТ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>DISSERTANT</subject></subj-group></article-categories><title-group><article-title>Возможности применения плазмы, обогащенной тромбоцитами, при заболеваниях и повреждениях крупных суставов</article-title><trans-title-group xml:lang="en"><trans-title>Therapeutic potential of platelet-rich plasma in diseases and injuries of the large joints</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Айрапетов</surname><given-names>Г. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Airapetov</surname><given-names>G. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., доцент кафедры травматологии и ортопедии Федерального государственного бюджетного образовательного учреждения высшего образования «Ставропольский государственный медицинский университет» Министерства здравоохранения Российской Федерации</p></bio><bio xml:lang="en"><p>Cand. of Sci. (Med.), Associate Professor of Chair of Traumatology and Orthopedics, Federal State Budgetary Educational Institution of Higher Education «Stavropol State Medical University» of the Ministry of Health of the Russian Federation</p></bio><email xlink:type="simple">AirapetovGA@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования «Ставропольский государственный&#13;
медицинский университет» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Educational Institution of Higher Education «Stavropol State Medical University» of the Ministry of Health of the&#13;
Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>05</day><month>03</month><year>2019</year></pub-date><volume>0</volume><issue>1</issue><fpage>84</fpage><lpage>87</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Айрапетов Г.А., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Айрапетов Г.А.</copyright-holder><copyright-holder xml:lang="en">Airapetov G.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/2903">https://www.med-sovet.pro/jour/article/view/2903</self-uri><abstract><p>Для лечения повреждений и заболеваний крупных суставов предложено много различных консервативных и оперативных методов. Небольшой костно-хрящевой дефект довольно быстро может увеличиться, а без должного лечения – привести к быстрому развитию остеоартрита. Хирургические методы лечения, такие как туннелизация, микрофрактурирование, мозаичная аутохондропластика и другие, можно улучшить, применяя экзогенные факторы роста. Одним из средств, которое содержит факторы, стимулирующие регенерацию, является плазма, обогащенная тромбоцитами (PRP). Обсуждается положительное воздействие PRP не только на хондрогенез в области дефектов гиалинового хряща, но и на проявления остеоартрита. Необходимо дальнейшее выяснение механизма воздействия плазмы и точной концентрации препарата.</p></abstract><trans-abstract xml:lang="en"><p>Numerous non-surgical and surgical procedures have been proposed to treat injuries and diseases of the large joints. Any small bone and cartilage defect can progress quite quickly and cause osteoarthritis to develop in many joints without proper treatment. Surgical procedures include tunnelization, microfracturing, mosaic autochondroplasty, etc. The joint condition can be improved by using exogenous growth factors. Platelet-rich plasma (PRP) is one of the remedies that contain regeneration-stimulating factors. The article discusses the positive effects of PRP not only on chondrogenesis in the area of hyaline cartilage defects, but also on osteoarthritis. There is a need to further clarify the mechanism of action of plasma and the exact concentration of the preparation.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>костно-хрящевой дефект</kwd><kwd>регенерация</kwd><kwd>плазма</kwd><kwd>PRP</kwd><kwd>остеоартрит</kwd></kwd-group><kwd-group xml:lang="en"><kwd>bone and cartilage defects</kwd><kwd>regeneration</kwd><kwd>plasma</kwd><kwd>PRP</kwd><kwd>osteoarthritis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Шевцов В.И., Макушин В.Д., Ступина Т.А., Степанов М.А. Экспериментальные аспекты изучения репаративной регенерации суставного хряща в условиях туннелирования субхондральной зоны с введением аутологичного костного мозга. 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