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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2019-8-66-70</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-2954</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКТУАЛЬНОЕ В ОТОРИНОЛАРИНГОЛОГИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ACTUAL IN OTORHINOLARYNGOLOGY</subject></subj-group></article-categories><title-group><article-title>Новые возможности мукоактивной терапии у больных с патологией респираторного тракта</article-title><trans-title-group xml:lang="en"><trans-title>New opportunities for mucioactive therapy in patients with pathology of the respiratory tract</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Свистушкин</surname><given-names>В. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Svistushkin</surname><given-names>V. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, завкафедрой болезней уха, горла и носа Федерального государственного автономного образовательного учреждения высшего образования «Первый Московский государственный медицинский университет имени И.М. Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский Университет)</p></bio><bio xml:lang="en"><p>Dr. of Sci. (Med.), Professor, Head of Chair of Ear, Nose &amp; Throat Diseases, Federal State Autonomous Educational Institution of Higher Education «Sechenov First Moscow State Medical University» (Sechenov University) of the Ministry of Heath of the Russian Federation (Sechenov University)</p></bio><email xlink:type="simple">svvm3@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никифорова</surname><given-names>Г. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikiforova</surname><given-names>G. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор кафедры болезней уха, горла и носа Федерального государственного автономного образовательного учреждения высшего образования «Первый Московский государственный медицинский университет имени И.М. Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский Университет)</p></bio><bio xml:lang="en"><p>Dr. of Sci. (Med.), Professor of Chair of Ear, Nose &amp; Throat Diseases, Federal State Autonomous Educational Institution of Higher Education «Sechenov First Moscow State Medical University» of the Ministry of Heath of the Russian Federation (Sechenov University)</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Меркушина</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Merkushinа</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ординатор кафедры болезней уха, горла и носа Федерального государственного автономного образовательного учреждения высшего образования «Первый Московский государственный медицинский университет имени И.М. Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский Университет)</p></bio><bio xml:lang="en"><p>Resident Physician of Chair for Ear, Nose &amp; Throat Diseases, Federal State Autonomous Educational Institution of Higher Education «Sechenov First Moscow State Medical University» of the Ministry of Heath of the Russian Federation (Sechenov University)</p></bio><email xlink:type="simple">dr.merkushina@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Федеральное государственное автономное образовательное учреждение высшего образования «Первый Московский государственный&#13;
медицинский университет имени И.М. Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский Университет)<country>Россия</country></aff><aff xml:lang="en">Federal State Autonomous Educational Institution of Higher Education First Moscow State Medical University named after I.M. Sechenov of&#13;
the Ministry of Health of the Russian Federation (Sechenov University)<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>18</day><month>04</month><year>2019</year></pub-date><volume>0</volume><issue>8</issue><fpage>66</fpage><lpage>70</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Свистушкин В.М., Никифорова Г.Н., Меркушина А.В., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Свистушкин В.М., Никифорова Г.Н., Меркушина А.В.</copyright-holder><copyright-holder xml:lang="en">Svistushkin V.M., Nikiforova G.N., Merkushinа A.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/2954">https://www.med-sovet.pro/jour/article/view/2954</self-uri><abstract><p>Наиболее частой причиной обращения пациентов к врачам первичного звена являются болезни органов дыхания. Анатомофизиологические особенности дыхательной системы человека и вид этиотропного агента обусловливают характерные черты патогенеза респираторной патологии. Важное клиническое значение имеет возможность самоочищения дыхательных путей – мукоцилиарный клиренс, но в ходе течения респираторных воспалительных заболеваний эффективность такого очищения значительно страдает в связи с формированием отека и усиленной выработкой более густого, чем предусматривает физиологическая норма, секрета. Практически все заболевания верхних и нижних отделов дыхательных путей сопровождаются нарушениями состава и реологических свойств секрета и затруднениями его эвакуации. Применение мукоактивных препаратов в лечении пациентов с воспалительной патологией дыхательных путей оказывает ощутимые клинический и экономический эффекты, уменьшая продолжительность заболевания, необходимость системной антибиотикотерапии, частоту и тяжесть рецидивов, положительно влияет на количество осложнений и качество жизни. Препарат Эльмуцин® (эрдостеин) производства российского фармацевтического предприятия «Оболенское», представитель секретолитиков и стимуляторов моторной функции дыхательных путей, является перспективным для использования в лечении больных респираторными заболеваниями, сопровождающимися образованием вязкой мокроты, в том числе в условиях неблагоприятной экологической обстановки.</p></abstract><trans-abstract xml:lang="en"><p>The most common cause of patients referring to primary care physicians are respiratory diseases. Anatomical and physiological features of the human respiratory system and the type of etiotropic agent determine the characteristic features of the pathogenesis of respiratory pathology. The possibility of self-purification of the respiratory tract is of significant clinical importance - mucociliary clearance, but during the course of respiratory inflammatory diseases, the effectiveness of such purification suffers significantly due to the formation of edema and the increased production of a secretion more dense than the physiological norm provides. Almost all diseases of the upper and lower respiratory tract are accompanied by violations of the composition and rheological properties of the secretion and difficulties in its evacuation. The use of mucoactive drugs in the treatment of patients with inflammatory pathology of the respiratory tract has a tangible economic and clinical effect, reducing the duration of the disease, the need for systemic antibiotic therapy, the frequency and severity of relapses, a positive effect on the number of complications and quality of life. The drug Elmultsin® (erdosteinе), produced by the Russian pharmaceutical company «Obolenskoye», is a representative of a group of secretolytics and respiratory motor function stimulants, is promising for use in the treatment of patients with respiratory diseases accompanied by the formation of viscous sputum, including in conditions of adverse environmental conditions.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>воспалительные респираторные заболевания</kwd><kwd>самоочищение дыхательных путей</kwd><kwd>мукоактивная терапия</kwd><kwd>секретолитики и стимуляторы моторной функции дыхательных путей</kwd><kwd>Эльмуцин® (эрдостеин)</kwd></kwd-group><kwd-group xml:lang="en"><kwd>inflammatory respiratory diseases</kwd><kwd>self-cleaning of the respiratory tract</kwd><kwd>mucoactive therapy</kwd><kwd>secretolytics and stimulants of the motor function of the respiratory tract</kwd><kwd>Elmultsin® (erdоsteinе)</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Клиническая лабораторная аналитика в пяти томах. 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