medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2019-6-34-40medsovet-2973Research ArticleНЕВРОЛОГИЯNEUROLOGYНовые возможности терапии скелетно-мышечной болиNew therapeutic options for musculoskeletal painДаниловА. Б.DanilovA. В.

Алексей Борисович Данилов – доктор медицинских наук, профессор кафедры нервных болезней Института последипломного образования Федерального государственного автономного образовательного учреждения высшего образования «Первый Московский государственный медицинский университет имени И.М. Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский университет), директор Института Междисциплинарной медицины

119991, г. Москва, ул. Большая Пироговская, д. 2, стр. 4

Alexei Borisovich Danilov – Dr. of Sci. (Med), Professor of the Department of Nervous Diseases of the Institute of Postgraduate Education of the Federal State Autonomous Educational Institution of Higher Education «First Moscow State Medical University named after I.M. Sechenov» of the Ministry of Health of the Russian Federation (Sechenov University), Director of the Institute of Interdisciplinary Medicine

119991, Moscow, B. Pirogovskaya St., 6, Bldg. 1

danilov@intermeda.ruКоржавинаВ. Б.KorzhavinaV. В.

Виктория Борисовна Коржавина – кандидат медицинских наук, ассистент кафедры нервных болезней Института последипломного образования 

119991, г. Москва, ул. Большая Пироговская, д. 2, стр. 4

Victoria Borisovna Korzhavina – Candidate of Medical Sciences, Assistant to the Department of Nervous Diseases of the Institute of Postgraduate Education

119991, Moscow, B. Pirogovskaya St., 6, Bldg. 1

victoria.doc@gmail.comФедеральное государственное автономное образовательное учреждение высшего образования «Первый Московский государственный медицинский университет имени И.М. Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский университет)РоссияFederal State Autonomous Educational Institution of Higher Education First Moscow State Medical University named after I.M. Sechenov of the Ministry of Health of the Russian Federation (Sechenov University)Russian Federation201925042019063440Copyright © Данилов А.Б., Коржавина В.Б., 20192019Данилов А.Б., Коржавина В.Б.Danilov A.В., Korzhavina V.В.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/2973

Скелетно-мышечная боль (СМБ) представляет собой одну из главных междисциплинарных проблем современной медицины и общества. Универсальным механизмом, играющим важнейшую роль в развитии острой и хронической СМБ, является воспаление. Поэтому нестероидные противовоспалительные препараты (НПВП) являются средством «первой линии» для лечения СМБ. Эффективность всех НПВП в отношении уменьшения боли и воспаления примерно одинакова, а степень безопасности определяется их отношением к ферментам ЦОГ-1 и ЦОГ-2. Благодаря фармакологическим свойствам и сбалансированному профилю эффективности и безопасности, удачную позицию «золотой середины» между коксибами и неселективными НПВП занимает умеренно-селективный ацеклофенак, что делает его использование целесообразным у подавляющего большинства пациентов с СМБ. Внедрение в клиническую практику препарата Ацеклагин, содержащего 200 мг ацеклофенака в новой лекарственной форме с модифицированным двухфазным высвобождением, открывает новые возможности терапии СМБ. Благодаря стабильной концентрации ацеклофенака в организме на протяжении суток, Ацеклагин позволяет повысить эффективность лечения боли и воспаления у пациентов с СМБ при сохранении высокого уровня безопасности, свойственной данной молекуле.

Musculoskeletal pain (MSP) is one of the major interdisciplinary problems of modern medicine and society. Inflammation is a universal mechanism that plays a crucial role in the development of acute and chronic MSP. Therefore, non-steroidal antiinflammatory drugs (NSAIDs) are the first-line treatment for MSP. The effectiveness of all NSAIDs in reducing pain and inflammation is approximately the same, and the degree of safety is determined by their relationship to COX-1 and COX-2 enzymes. Thanks to pharmacological properties and a balanced profile of efficiency and safety, the successful position of the «golden mean» between cokebins and non-selective NSAIDs is a moderately selective aceklofenac, which makes it appropriate for the vast majority of patients with MSP. Introduction into clinical practice of the drug Aceklagin containing 200 mg of aceсlofenaс in a new drug form with modified two-phase release, opens up new possibilities of MSP therapy. Due to the stable concentration of aceclofenac in the body during the day, Aceklagin improves the efficiency of pain and inflammation treatment in patients with MSP, while maintaining a high level of safety inherent in this molecule.

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The authors declare that there are no conflicts of interest present.