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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2019-6-68-73</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-2979</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>БРОНХОПУЛЬМОНОЛОГИЯ, ЛОР</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>BRONCHOPULMONOLOGY, ENT</subject></subj-group></article-categories><title-group><article-title>Патогенетическая терапия риносинуситов в практике врача-оториноларинголога</article-title><trans-title-group xml:lang="en"><trans-title>Pathogenetic therapy of rhinosinusites in the practice of otorhinolaryngologist</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рязанцев</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ryazantsev</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рязанцев Сергей Валентинович – доктор медицинских наук, профессор, заместитель директора по научно-координационной работе</p><p>190013, г. Санкт-Петербург, ул. Бронницкая, д. 9 </p></bio><bio xml:lang="en"><p>Ryazantsev Sergey Valentinovich – Dr. of Sci. (Med), Professor, Deputy Director for Scientific Coordination</p><p> 190013, St. Petersburg, Bronnitskaya, 9 </p></bio><email xlink:type="simple">professor.ryazantsev@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1110-7087</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фанта</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Fanta</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Фанта Иван Васильевич – кандидат медицинских наук, заведующий организационно-методическим отделом</p><p>190013, г. Санкт-Петербург, ул. Бронницкая, д. 9 </p></bio><bio xml:lang="en"><p>Fanta Ivan Vasilyevich – Cand. of Sci. (Med.), Head of the Organizational and Methodical Department</p><p> 190013, St. Petersburg, Bronnitskaya, 9 </p></bio><email xlink:type="simple">3165429@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9976-3830</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Павлова</surname><given-names>С. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Pavlova</surname><given-names>S. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Павлова Светлана Сергеевна – врач-оториноларинголог, младший научный сотрудник организационно-методического отдела</p><p>190013, г. Санкт-Петербург, ул. Бронницкая, д. 9 </p></bio><bio xml:lang="en"><p>Pavlova Svetlana Sergeevna - otorhinolaryngologist, junior researcher of the organizational and methodical department</p><p> 190013, St. Petersburg, Bronnitskaya, 9 </p></bio><email xlink:type="simple">ilanasergeeva@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное учреждение «Санкт-Петербургский научно-исследовательский институт уха, горла, носа и речи» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Institution Federal State Budgetary Institution «Saint-Petersburg ENT and Speech Research Institute» of the Ministry of Healthcare of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>26</day><month>04</month><year>2019</year></pub-date><volume>0</volume><issue>6</issue><fpage>68</fpage><lpage>73</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Рязанцев С.В., Фанта И.В., Павлова С.С., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Рязанцев С.В., Фанта И.В., Павлова С.С.</copyright-holder><copyright-holder xml:lang="en">Ryazantsev S.V., Fanta I.V., Pavlova S.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/2979">https://www.med-sovet.pro/jour/article/view/2979</self-uri><abstract><p>Важной и актуальной проблемой современной оториноларингологии является поиск эффективных и безопасных лекарственных средств для лечения бактериального синусита, который относится к числу наиболее распространенных заболеваний человека, и эта проблема с каждым годом становится все актуальнее. При назначении антибактериальной терапии пациентам с острым и хроническим риносинуситом врачу-оториноларингологу необходимо быть уверенным в том, что препарат обладает быстрым бактерицидным эффектом, спектр его активности включает в себя большинство возможных возбудителей, а фармакодинамика препарата способствует его накоплению в очаге патологического процесса.</p></abstract><trans-abstract xml:lang="en"><p>An important and topical problem of modern otorhinolaryngology is the search for effective and safe medicines for the treatment of bacterial sinusitis, which is one of the most common human diseases, and this problem is becoming more and more acute every year. When prescribing antibacterial therapy for patients with acute and chronic rhinosinusitis, an otorhinolaryngologist should be sure that the drug has a rapid bactericidal effect, the spectrum of its activity includes most of the possible pathogens, and pharmacodynamics of the drug contribute to its accumulation in the focus of the pathological process.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>риносинусит</kwd><kwd>антибактериальная терапия</kwd><kwd>цефалоспорины 3-го поколения</kwd><kwd>цефдиторен</kwd><kwd>Спектрацеф</kwd></kwd-group><kwd-group xml:lang="en"><kwd>rhinosinusitis</kwd><kwd>antibacterial therapy</kwd><kwd>3 generation cephalosporins</kwd><kwd>cefditoren</kwd><kwd>Spektracef</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Принципы этиопатогенетической терапии острых синуситов: методические рекомендации. Под ред. С. В. Рязанцева. 3-е изд. 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