<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2019-6-95-99</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-2983</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>РЕВМАТОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>RHEUMATOLOGY</subject></subj-group></article-categories><title-group><article-title>Узловатая эритема при ревматических заболеваниях</article-title><trans-title-group xml:lang="en"><trans-title>Erythema nodosum in rheumatic diseases</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Егорова</surname><given-names>О. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Egorova</surname><given-names>О. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Егорова Ольга Николаевна – кандидат медицинских наук, ревматолог, старший научный сотрудник лаборатории изучения коморбидных инфекций и  мониторинга безопасности лекарственной  терапии</p><p>115522, г. Москва, Каширское шоссе, д. 34А  </p></bio><bio xml:lang="en"><p>Egorova Olga Nikolaevna – Ph. D., rheumatologist, senior researcher of the laboratory for  the study of comorbid infections and  monitoring the safety of drug therapy</p><p>115522, Moscow, Kashirskoye sh.,34 А.  </p></bio><email xlink:type="simple">onegorova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белов</surname><given-names>Б. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Belov</surname><given-names>В. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Белов Борис Сергеевич – доктор медицинских наук, ревматолог,  заведующий лабораторией изучения  коморбидных инфекций и мониторинга  безопасности лекарственной терапии </p><p>115522, г. Москва, Каширское шоссе, д. 34А  </p></bio><bio xml:lang="en"><p>Belov Boris Sergeevich – MD, rheumatologist,  head of the laboratory for the study of  comorbid infections and monitoring the  safety of drug therapy</p><p>115522, Moscow, Kashirskoye sh.,34 А.  </p></bio><email xlink:type="simple">belovbor@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное научное учреждение «Научно-исследовательский институт ревматологии  имени В.А. Насоновой»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>27</day><month>04</month><year>2019</year></pub-date><volume>0</volume><issue>6</issue><fpage>95</fpage><lpage>99</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Егорова О.Н., Белов Б.С., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Егорова О.Н., Белов Б.С.</copyright-holder><copyright-holder xml:lang="en">Egorova О.N., Belov В.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/2983">https://www.med-sovet.pro/jour/article/view/2983</self-uri><abstract><p>Обзор посвящен узловатой эритеме (УЭ), которая является типичным вариантом септального панникулита без васкулита и представляет собой неспецифический иммуновоспалительный синдром. Нередко УЭ выступает как один из симптомов системной  патологии, включая ревматические заболевания (РЗ), саркоидоз, болезнь Крона, неспецифический язвенный колит, онкологические болезни и т. д., что может послужить причиной поздней диагностики и, соответственно, назначения адекватной терапии. </p></abstract><trans-abstract xml:lang="en"><p>The review is devoted to erythema nodosum (UE), which is a typical variant of septal panniculitis without vasculitis and is a  nonspecific immune inflammatory syndrome. Often, UE acts as one of the symptoms of systemic pathology, including rheumatic  diseases (RH), sarcoidosis, Crohn’s disease, ulcerative colitis, cancer, etc., which can cause late diagnosis and, accordingly, the  appointment of adequate therapy. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>узловатая эритема</kwd><kwd>этиология</kwd><kwd>патогенез</kwd><kwd>патоморфология</kwd><kwd>клиника</kwd><kwd>ревматические заболевания</kwd></kwd-group><kwd-group xml:lang="en"><kwd>erythema nodosum</kwd><kwd>etiology</kwd><kwd>pathogenesis</kwd><kwd>pathomorphology</kwd><kwd>clinic</kwd><kwd>rheumatic diseases</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Wick M.R. Panniculitis: а summary. Seminars in diagnostic pathology. 2017;34(3):261–272.</mixed-citation><mixed-citation xml:lang="en">Wick M.R. Panniculitis: а summary. Seminars in  diagnostic pathology. 2017;34(3):261–272.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Caputo V., Rongioletti F. Panniculitis in the setting of dermato/rheumatologic diseases. Giornale italiano di dermatologia e Venereologia. 2018;53(2):194-207.</mixed-citation><mixed-citation xml:lang="en">Caputo V., Rongioletti F. Panniculitis in the setting of dermato/rheumatologic diseases.  Giornale italiano di dermatologia e Venereologia.  2018;53(2):194-207.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Rebsamen U., Guenova Е., Vallelian F. CME: Erythema nodosum. Praxis. 2017;106(18):973– 979.</mixed-citation><mixed-citation xml:lang="en">Rebsamen U., Guenova Е., Vallelian F. CME:  Erythema nodosum. Praxis. 2017;106(18):973–  979.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Шапошников О.К. Хроническая узловатая эритема. Ленинград, 1971:3-42.</mixed-citation><mixed-citation xml:lang="en">Shaposhnikov  О.K. Chronic erythema nodosum. Leningrad,  1971:3-42. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Вермель А.Е. Узловатая эритема в клинике внутренних болезней. Клиническая медицина. 2004;4:4-9.</mixed-citation><mixed-citation xml:lang="en">Vermel A.E. Erythema nodosum in  the clinic of internal diseases. Klinicheskaya  Meditsina. 2004;4:4-9. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Garcı´a-Porru´a C., Gonza´lez-Gay M.A., Va´zquez-Caruncho M. et al. Erythema nodosum: etiologic and predictive factors in defined population. Arthritis. Rheum. 2000;43:584–592.</mixed-citation><mixed-citation xml:lang="en">Garcı´a-Porru´a C., Gonza´lez-Gay M.A.,  Va´zquez-Caruncho M. et al. Erythema nodosum: etiologic and predictive factors in defined  population. Arthritis. Rheum. 2000;43:584–592.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Niemi K.M., Forstrom L., Hannuksela M. et al. Nodules on the legs. Acta. Derm. Venereol. 1977;57:145–154.</mixed-citation><mixed-citation xml:lang="en">Niemi K.M., Forstrom L., Hannuksela M. et al.  Nodules on the legs. Acta. Derm. Venereol.  1977;57:145–154.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Nunnery E., Persellin R.H., Pope R.M. Lack of circulating immune complexes in uncomplicated erythema nodosum. J. Rheumatol. 1983;10:991–994.</mixed-citation><mixed-citation xml:lang="en">Nunnery E., Persellin R.H., Pope R.M. Lack of  circulating immune complexes in uncomplicated erythema nodosum. J. Rheumatol.  1983;10:991–994.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Хамаганова И.В. Узловатая эритема у больных с гипертрофией носоглоточной миндалины. Вестн. дермат. 1989;11:60-62.</mixed-citation><mixed-citation xml:lang="en">Khamaganova  I.V. Erythema nodosum in patients with hypertrophy of nasopharyngeal tonsil. Vestn. Dermat.  1989;11:60-62 (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Montgomery H., O´Leary P.A., Barker N.W. Diseasis of the skin. JAMA. 1945;128:335-341.</mixed-citation><mixed-citation xml:lang="en">Montgomery H., O´Leary P.A., Barker N.W.  Diseasis of the skin. JAMA. 1945;128:335-341.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Kutlubay Z., Mat C.M., Aydin Ö. et al. Histopathological and clinical evaluation of papulopustular lesions in Behçet’s disease. Clin Exp Rheumatol. 2015;33(6 Suppl 94):101-106.</mixed-citation><mixed-citation xml:lang="en">Kutlubay Z., Mat C.M., Aydin Ö. et al.  Histopathological and clinical evaluation of  papulopustular lesions in Behçet’s disease. Clin  Exp Rheumatol. 2015;33(6 Suppl 94):101-106.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Irgang S. Nodular vasculitis; report of a case with clinical resemblance to papulonecrotic tuberculid. Arch. Dermat. Syph. 1956;74:673-75.</mixed-citation><mixed-citation xml:lang="en">Irgang S. Nodular vasculitis; report of a case  with clinical resemblance to papulonecrotic  tuberculid. Arch. Dermat. Syph. 1956;74:673-75.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Porges T., Shafat T., Sagy I. et al. Clinical, epidemiological, and etiological changes in erythema nodosum. Isr Med Assoc J. 2018;20(12):770- 772.</mixed-citation><mixed-citation xml:lang="en">Porges T., Shafat T., Sagy I. et al. Clinical, epidemiological, and etiological changes in erythema nodosum. Isr Med Assoc J. 2018;20(12):770-  772.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Hellerström S. Erythema nodosum. Acta Derm Venereol. 1966;46(6):469-72.</mixed-citation><mixed-citation xml:lang="en">Hellerström S. Erythema nodosum. Acta Derm  Venereol. 1966;46(6):469-72.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">White W.L., Hichcock M.G. Diagnosis:erythema nodosum or not? Semin. Cutan. Med. Surg. 1999;18:47-55.</mixed-citation><mixed-citation xml:lang="en">White W.L., Hichcock M.G. Diagnosis:erythema  nodosum or not? Semin. Cutan. Med. Surg.  1999;18:47-55.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Kisacik B., Onat A.M., Pehlivan Y. Multiclinical experiences in erythema nodosum: rheumatology clinics versus dermatology and infection diseases clinics. Rheum. International. 2013;33(2):315–318.</mixed-citation><mixed-citation xml:lang="en">Kisacik B., Onat A.M., Pehlivan Y. Multiclinical  experiences in erythema nodosum: rheumatology clinics versus dermatology and infection  diseases clinics. Rheum. International.  2013;33(2):315–318.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Mert A., Kumbasar H., Ozaras R. et al.Erythema nodosum: an evaluation of 100 cases. Clinical and experimental rheumatology. 2007;25(4):563–570.</mixed-citation><mixed-citation xml:lang="en">Mert A., Kumbasar H., Ozaras R. et al.Erythema  nodosum: an evaluation of 100 cases. Clinical  and experimental rheumatology.  2007;25(4):563–570.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Papagrigoraki A., Gisondi P., Rosina P. et al. Erythema nodosum: etiological factors and relapses in a retrospective cohort study. European journal of dermatology. 2010;20(6):773–777.</mixed-citation><mixed-citation xml:lang="en">Papagrigoraki A., Gisondi P., Rosina P. et al.  Erythema nodosum: etiological factors and  relapses in a retrospective cohort study.  European journal of dermatology.  2010;20(6):773–777.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Ajubi N., Nossent J.C. Panniculitis as the first manifestation of systemic lupus erythematosus: description of two cases. The Netherlands journal of medicine. 1993;42(1–2):25–29.</mixed-citation><mixed-citation xml:lang="en">Ajubi N., Nossent J.C. Panniculitis as the first  manifestation of systemic lupus erythematosus: description of two cases. The Netherlands  journal of medicine. 1993;42(1–2):25–29.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Rezgui A., Hassine I.B., Karmani M. et al. Amyloïdosis, sarcoidosis and systemic lupus erythematosus. The Pan African medical journal. 2016;24:23.</mixed-citation><mixed-citation xml:lang="en">Rezgui A., Hassine I.B., Karmani M. et al.  Amyloïdosis, sarcoidosis and systemic lupus  erythematosus. The Pan African medical journal.  2016;24:23.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Verschueren K., Van Essche E., Verschueren P. et al. Deve lopment of sarcoidosis in etanercepttreated rheumatoid arthritis patients. Clinical rheumatology. 2007;26(11):1969–1971.</mixed-citation><mixed-citation xml:lang="en">Verschueren K., Van Essche E., Verschueren P. et  al. Deve lopment of sarcoidosis in etanercepttreated rheumatoid arthritis patients. Clinical  rheumatology. 2007;26(11):1969–1971.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Shioya N., Shibata S., Kojika M., Endo S. Multiple transverse colonic perforations associated with slow-release nonsteroidal antiinflammatory drugs and corticosteroids: a case report. Case reports in critical care. 2011; Article ID 824639: 4 р.</mixed-citation><mixed-citation xml:lang="en">Shioya N., Shibata S., Kojika M., Endo S.  Multiple transverse colonic perforations associated with slow-release nonsteroidal antiinflammatory drugs and corticosteroids: a case  report. Case reports in critical care. 2011; Article  ID 824639: 4 р.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Yamamoto T., Yokoyama A., Yamamoto Y., Mamada A. Erythema nodosum associated with Sjögren’s syndrome. British journal of rheumatology. 1997;36(6):707–708.</mixed-citation><mixed-citation xml:lang="en">Yamamoto T., Yokoyama A., Yamamoto Y.,  Mamada A. Erythema nodosum associated with  Sjögren’s syndrome. British journal of rheumatology. 1997;36(6):707–708.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Васильев В.И., Логвиненко О.А., Симонова М.В. и соавт. Развитие сухого синдрома при саркоидозе с поражением слюнных желез. Тер. архив. 2005;77(1):62–67.</mixed-citation><mixed-citation xml:lang="en">Vasilyev V.I.,  Logvinenko O.A., Simonova M.V., et al.  Development of dry syndrome in sarcoidosis  with damage to the salivary glands. Ter. Archive.  2005;77(1):62–67. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Nekhlyudov L., Gradzka M., Conti-Kelly A.M., Greco T.P. Erythema nodosum associated with antiphospholipid antibodies:a report of three cases. Lupus. 2000;9(8):641–645.</mixed-citation><mixed-citation xml:lang="en">Nekhlyudov L., Gradzka M., Conti-Kelly A.M.,  Greco T.P. Erythema nodosum associated with  antiphospholipid antibodies:a report of three  cases. Lupus. 2000;9(8):641–645.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Remondino G.I., Mysler E., Pissano M.N. et al. A reversible bilateral renal artery stenosis in association with antiphospholipid syndrome. Lupus. 2000;9(1):65–67.</mixed-citation><mixed-citation xml:lang="en">Remondino G.I., Mysler E., Pissano M.N. et al. A  reversible bilateral renal artery stenosis in  association with antiphospholipid syndrome.  Lupus. 2000;9(1):65–67.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Раденска-Лоповок С.Г., Решетняк Т.М., Забек Я., Войцеховская Б. Морфологические особенности сосудов при антифосфолипидном синдроме. Архив патологии. 2001;6:8–11.</mixed-citation><mixed-citation xml:lang="en">RadenskaLopovok S.G., Reshetnyak T.M., Zabek J.,  Wojciechowska B. Morphological features of  the vessels in the antiphospholipid syndrome.  Arkhiv Patologii. 2001;6:8–11. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Rosa Neto N.S., Gauditano G., Yoshinari N.H. Chronic lymphomonocytic meningoencephalitis, oligoarthritis and erythema nodosum: report of Baggio-Yoshinari syndrome of long and relapsing evolution. Revista brasileira de reumatologia. 2014;54(2):148–151.</mixed-citation><mixed-citation xml:lang="en">Rosa Neto N.S., Gauditano G., Yoshinari N.H.  Chronic lymphomonocytic meningoencephalitis, oligoarthritis and erythema nodosum:  report of Baggio-Yoshinari syndrome of long  and relapsing evolution. Revista brasileira de  reumatologia. 2014;54(2):148–151.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Dittmer M.R., Willis M.S., Selby J.C., Liu V. Septolobular panniculitis in disseminated Lyme borreliosis. J. cutan. Рathology. 2018;45(4):274– 277.</mixed-citation><mixed-citation xml:lang="en">Dittmer M.R., Willis M.S., Selby J.C., Liu V.  Septolobular panniculitis in disseminated Lyme  borreliosis. J. cutan. Рathology. 2018;45(4):274–  277.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
