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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2019-6-116-124</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-2986</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ИНФЕКЦИОННЫЕ БОЛЕЗНИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>INFECTIOUS DISEASES</subject></subj-group></article-categories><title-group><article-title>Витамин D и острые респираторные инфекции:  профилактика или лечение?</article-title><trans-title-group xml:lang="en"><trans-title>Vitamin D and acute respiratory infections:  prevention or treatment?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лазарева</surname><given-names>Н. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Lazareva</surname><given-names>N. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лазарева Наталья Борисовна – доктор медицинских наук, профессор кафедры клинической фармакологии и пропедевтики внутренних болезней </p><p>119991, г. Москва, ул. Трубецкая, д. 8, стр. 2  </p></bio><bio xml:lang="en"><p>Lazareva Nataliya Borisovna – Dr. of Sci.  (Med.), Professor of the Chair for Clinical  Pharmacology and Propaedeutics of Internal  Diseases</p><p>8, Trubetskaya Street, Moscow, 119991, p. 2  </p></bio><email xlink:type="simple">natalia.lazareva@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Реброва</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Rebrova</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Реброва Екатерина Владиславовна – кандидат медицинских наук,  доцент кафедры клинической фармакологии и пропедевтики внутренних болезней  </p><p>119991, г. Москва, ул. Трубецкая, д. 8, стр. 2  </p></bio><bio xml:lang="en"><p>Rebrova Ekaterina Vladislavovna – Cand. of  Sci. (Med.), Associate Professor of the Chair  for Clinical Pharmacology and Propaedeutics  of Internal Diseases</p><p>8, Trubetskaya Street, Moscow, 119991, p. 2  </p></bio><email xlink:type="simple">katrina1987@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пантелеева</surname><given-names>Л. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Panteleeva</surname><given-names>L. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пантелеева Лола Реминджановна – кандидат медицинских наук,  доцент кафедры клинической фармакологии и пропедевтики внутренних болезней </p><p>119991, г. Москва, ул. Трубецкая, д. 8, стр. 2  </p></bio><bio xml:lang="en"><p>Panteleeva Lola Remindzhanovna – Cand. of  Sci. (Med.), Associate Professor of the Chair  for Clinical Pharmacology and Propaedeutics  of Internal Diseases</p><p>8, Trubetskaya Street, Moscow, 119991, p. 2  </p></bio><email xlink:type="simple">panteleeva.l@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рязанова</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Ryazanova</surname><given-names>A. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рязанова Анастасия Юрьевна – доцент  кафедры клинической фармакологии и  интенсивной терапии, с курсом клинической фармакологии ФУВ, клинической  аллергологии ФУВ</p><p>400131, г. Волгоград, пл. Павших борцов, д. 1  </p></bio><bio xml:lang="en"><p>Ryazanova Anastasia Yuryevna – Associate  Professor of the Chair for Clinical  Pharmacology and Intensive Therapy with a  course of Clinical Pharmacology of Faculty of  Continuing Medical Education, Clinical  Allergology of Faculty of Continuing Medical  Education</p><p>400131, Volgograd, pl. Pavshikh Bortsov, 1</p></bio><email xlink:type="simple">nastasyakus@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бондаренко</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Bondarenko</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бондаренко Дмитрий Александрович – студент лечебного факультета</p><p>119991, г. Москва, ул. Трубецкая, д. 8, стр. 2  </p></bio><bio xml:lang="en"><p>Bondarenko Dmitri Alexandrovich – a student of the Chair for Clinical Pharmacology  and Propaedeutics of Internal Diseases</p><p>8, Trubetskaya Street, Moscow, 119991, p. 2  </p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Федеральное государственное автономное образовательное учреждение высшего образования «Первый Московский государственный медицинский университет имени И.М. Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский  Университет)<country>Россия</country></aff><aff xml:lang="en">Federal State Autonomous Educational Institution of Higher Education First Moscow State Medical University named after I.M. Sechenov of  the Ministry of Health of the Russian Federation (Sechenov University)<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Федеральное государственное бюджетное образовательное учреждение высшего образования «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации<country>Россия</country></aff><aff xml:lang="en">Federal State Budgetary Educational Institution of Higher Education «Volgograd State Medical University» of the Ministry of Health of the  Russian Federation<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>27</day><month>04</month><year>2019</year></pub-date><volume>0</volume><issue>6</issue><fpage>116</fpage><lpage>124</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Лазарева Н.Б., Реброва Е.В., Пантелеева Л.Р., Рязанова А.Ю., Бондаренко Д.А., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Лазарева Н.Б., Реброва Е.В., Пантелеева Л.Р., Рязанова А.Ю., Бондаренко Д.А.</copyright-holder><copyright-holder xml:lang="en">Lazareva N.B., Rebrova E.V., Panteleeva L.R., Ryazanova A.Y., Bondarenko D.A.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/2986">https://www.med-sovet.pro/jour/article/view/2986</self-uri><abstract><p>Витамин D обладает большим количеством биологических эффектов благодаря влиянию на рецептор витамина D, который  присутствует в большинстве тканей организма. Возможная роль витамина D при инфекциях объясняется его влиянием на  механизмы врожденного и приобретенного иммунного ответа. Немаловажным действием витамина D является также подавление им воспалительных процессов.  Поскольку дефицит витамина D многими учеными относится к так называемым «сезонным стимуляторам» развития острых  респираторных вирусных инфекций (ОРВИ), особенный интерес вызывают возможности профилактического и терапевтического применения витамина D в сезон ОРВИ и гриппа.  Наиболее важным фактом, доказывающим возможную протективную роль витамина D при гриппе и других острых респираторных инфекциях, является 25-гидроксикальциферол-стимулированная продукция антимикробных пептидов, таких как  дефенсин и кателицидин. Эти эндогенные пептиды действуют напрямую, разрушая не только микробные патогены, но и вирусы, в т. ч. вирус гриппа. </p></abstract><trans-abstract xml:lang="en"><p>Vitamin D has a large number of biological effects due to the effect on the vitamin D receptor, which is present in most tissues in  the body. The possible role of vitamin D in infections is explained by its effect on the mechanisms of the innate and acquired immune  response. Suppression of the inflammatory response is also an important effect of vitamin D.  Many scientists strongly believe that vitamin D deficiency is among the so-called «seasonal stimulators» of acute respiratory viral  infections (ARVI), the potential for the prophylactic and therapeutic use of vitamin D in the season of ARVI and influenza is of particular interest.  25-hydroxycalciferol-stimulated production of antimicrobial peptides, such as defensin and cathelicidin is the most important fact  proving the possible protective role of vitamin D in influenza and other acute respiratory infections. These endogenous peptides  have a direct action, destroying not only microbial pathogens, but also viruses, including the influenza virus. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>витамин D</kwd><kwd>инфекции дыхательных путей</kwd><kwd>грипп</kwd><kwd>ДЕТРИМАКС витамин D3</kwd></kwd-group><kwd-group xml:lang="en"><kwd>vitamin D</kwd><kwd>respiratory tract infections</kwd><kwd>flu</kwd><kwd>DETRIMAX vitamin D3</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Martineau A.R., Jolliffe D.A., Hooper R.L., Greenberg L., Aloia J.F., Bergman P. et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. 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