medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2019-9-8-13medsovet-3029Research ArticleЦЕРЕБРОВАСКУЛЯРНЫЕ ЗАБОЛЕВАНИЯCEREBROVASCULAR DISEASESСочетание и взаимовлияние болезни Альцгеймера и цереброваскулярной патологииCombination and mutual effect of Alzheimer’s disease and cerebrovascular diseaseПарфеновВ. А.ParfenovV. A.

д.м.н., профессор, завкафедрой нервных болезней и нейрохирургии Федерального государственного автономного образовательного учреждения высшего образования «Первый Московский государственный медицинский университет имени И.М. Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский университет), директор Клиники нервных болезней им. А.Я. Кожевникова Первого МГМУ имени И.М. Сеченова.

Dr. of Sci. (Med), Professor, Head of the Department of Nervous Diseases and Neurosurgery of the Federal State Autonomous Educational Institution of Higher Education First Moscow State Medical University named after I.M. Sechenov of the Ministry of Health of the Russian Federation (Sechenov University), Director of the Clinic of Nervous Diseases named after A.Y. Kozhevnikov of the First Moscow State Medical University named after I.M. Sechenov.

vladimirparfenov@mail.ruФедеральное государственное автономное образовательное учреждение высшего образования «Первый Московский государственный медицинский университет имени И.М. Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский университет).РоссияFederal State Autonomous Educational Institution of Higher Education First Moscow State Medical University named after I.M. Sechenov of the Ministry of Health of the Russian Federation (Sechenov University.Russian Federation20191006201909813Copyright © Парфенов В.А., 20192019Парфенов В.А.Parfenov V.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/3029

Болезнь Альцгеймера (БА), цереброваскулярная патология и их сочетание представляют наиболее частую причину когнитивных нарушений (КН) и вследствие этого инвалидности пожилых людей. Анализируются взаимовлияние, проявления и диагностика БА и сосудистых КН. Наличие сосудистого компонента в развитии КН указывает на возможность их профилактики. Лечение КН основано на коррекции сосудистых факторов, нелекарственных и лекарственных методах улучшения когнитивных функций. При деменции эффективны психосоциальные и поведенческие методы, когнитивный тренинг, ингибиторы центральной ацетилхолинэстеразы и мемантин. Обсуждается использование церебролизина при БА и сосудистых КН.

Alzheimer’s disease (AD), cerebrovascular disease and their combination are the most common causes of cognitive impairment (CI) and therefore disability in senior citizens. Mutual influences, manifestations and diagnostics of AD and vascular CI are analyzed. The presence of a vascular component in the development of CI indicates the possibility of their prevention. Treatment of CI is based on correction of vascular factors, non-drug and drug methods to improve cognitive functions. Psychosocial and behavioral methods, cognitive training, central acetylcholinesterase inhibitors and memantine are effective in dementia. The use of cerebrolysine in AD and vascular CI is discussed.

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The authors declare that there are no conflicts of interest present.