<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2019-9-86-91</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-3039</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>РЕВМАТОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>RHEUMATOLOGY</subject></subj-group></article-categories><title-group><article-title>Коморбидные инфекции при ревматических заболеваниях (по данным ФГБНУ НИИР им. В.А. Насоновой)</article-title><trans-title-group xml:lang="en"><trans-title>Comorbid infections in rheumatic diseases (according to FSBI RIR named after V.A. Nasonova)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Буханова</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bukhanova</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант лаборатории изучения коморбидных инфекций и мониторинга безопасности лекарственной терапии Федерального государственного бюджетного научного учреждения «Научно-исследовательский институт ревматологии имени В.А. Насоновой».</p></bio><bio xml:lang="en"><p>Postgraduate Student of the Laboratory for the Study of Comorbid Infections and Monitoring of Drug Therapy Safety of the Federal State Budgetary Institution «Research Institute of Rheumatology named after V.A. Nasonova».</p></bio><email xlink:type="simple">rheumodaria@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белов</surname><given-names>Б. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Belov</surname><given-names>B. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., зав. лабораторией изучения коморбидных инфекций и мониторинга безопасности лекарственной терапии Федерального государственного бюджетного научного учреждения «Научно-исследовательский институт ревматологии имени В.А. Насоновой».</p></bio><bio xml:lang="en"><p>Dr. of Sci. (Med), Head of the Laboratory for the Study of Comorbid Infections and Monitoring of Drug Therapy Safety of the Federal State Budge tary Institution «Research Institute of Rheu matology named after V.A. Nasonova».</p></bio><email xlink:type="simple">belovbor@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тарасова</surname><given-names>Г. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Tarasova</surname><given-names>G. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., старший научный сотрудник лаборатории изучения коморбидных инфекций и мониторинга безопасности лекарственной терапии Федерального государственного бюджетного научного учреждения «Научно-исследовательский институт ревматологии имени В.А. Насоновой».</p></bio><bio xml:lang="en"><p>Cand. of Sci. (Med.), Senior Researcher of the Laboratory for Comorbid Infections and Monitoring of Drug Therapy Safety of the Federal State Budgetary Institution «Research Institute of Rheumatology named after V.A. Nasonova».</p></bio><email xlink:type="simple">verizubgm@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соловьев</surname><given-names>С. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Soloviev</surname><given-names>S. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., проф., зав. лабораторией интенсивных методов терапии Федерального государственного бюджетного научного учреждения «Научно-исследовательский институт ревматологии имени В.А. Насоновой».</p></bio><bio xml:lang="en"><p>Dr. of Sci. (Med), Professor, Head of the Laboratory of Intensive Therapy Methods of the Federal State Budgetary Institution «Research Institute of Rheumatology named after V.A. Nasonova».</p></bio><email xlink:type="simple">sksoloviev@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ананьева</surname><given-names>Л. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Ananyeva</surname><given-names>L. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., проф., зав. лабораторией микроциркуляции и воспаления Федерального государственного бюджетного научного учреждения «Научно-исследовательский институт рев-матологии имени В.А. Насоновой».</p></bio><bio xml:lang="en"><p>Dr. of Sci. (Med), Professor, Head of the Laboratory of Microcirculation and Inflammation of the Federal State Budgetary Institution «Research Institute of Rheumatology named after V.A. Nasonova».</p></bio><email xlink:type="simple">ananieva@irramn.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Попкова</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Popkova</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., зав. лабораторией системных ревматических заболеваний Федерального государственного бюджетного научного учреждения «Научно-исследовательский институт ревматологии имени В.А. Насоновой».</p></bio><bio xml:lang="en"><p>Dr. of Sci. (Med), Head of the Laboratory of Systemic Rheumatic Diseases of the Federal State Budgetary Institution «Research Institute of Rheumatology named after V.A. Nasonova».</p></bio><email xlink:type="simple">popkovatv@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гордеев</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Gordeev</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, зав. лабораторией ранних артритов Федерального государственного бюджетного научного учреждения «Научно-исследовательский институт ревматологии имени В.А. Насоновой».</p></bio><bio xml:lang="en"><p>Dr. of Sci. (Med), Professor, Head of the Early Arthritis Laboratory of the Federal State Budgetary Institution «Research Institute of Rheumatology named after V.A. Nasonova».</p></bio><email xlink:type="simple">avg1305@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Муравьев</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Muravyov</surname><given-names>Yu. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, ведущий научный сотрудник лаборатории изучения коморбидных инфекций и мониторинга безопасности лекарственной терапии Федерального государственного бюджетного научного учреждения «Научно-исследовательский институт ревматологии имени В.А. Насоновой».</p></bio><bio xml:lang="en"><p>Dr. of Sci. (Med), Professor, Leading Researcher of the Comorbid Infections and Drug Therapy Safety Monitoring Laboratory of the Federal State Budgetary Institution «Research Institute of Rheumatology named after V.A. Nasonova».</p></bio><email xlink:type="simple">murawyu@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Глухова</surname><given-names>С. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Glukhova</surname><given-names>S. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.ф.-м.н., старший научный сотрудник лаборатории медико-социальных проблем ревматологии Федерального государственного бюджетного научного учреждения «Научно-исследовательский институт ревматологии имени В.А. Насоновой».</p></bio><bio xml:lang="en"><p>Cand. of Sci. (Physics and Mathematics.), Senior Researcher of the Laboratory of Medical and Social Problems of Rheumatology of the Federal State Budgetary Institution «Research Institute of Rheumatology named after V.A. Nasonova».</p></bio><email xlink:type="simple">sveglukhova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное научное учреждение «Научно-исследовательский институт ревматологии имени В.А. Насоновой».</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Institution «Research Institute of Rheumatology named after V.A. Nasonova».</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>11</day><month>06</month><year>2019</year></pub-date><volume>0</volume><issue>9</issue><fpage>86</fpage><lpage>91</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Буханова Д.В., Белов Б.С., Тарасова Г.М., Соловьев С.К., Ананьева Л.П., Попкова Т.В., Гордеев А.В., Муравьев Ю.В., Глухова С.И., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Буханова Д.В., Белов Б.С., Тарасова Г.М., Соловьев С.К., Ананьева Л.П., Попкова Т.В., Гордеев А.В., Муравьев Ю.В., Глухова С.И.</copyright-holder><copyright-holder xml:lang="en">Bukhanova D.V., Belov B.S., Tarasova G.M., Soloviev S.K., Ananyeva L.P., Popkova T.V., Gordeev A.V., Muravyov Y.V., Glukhova S.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/3039">https://www.med-sovet.pro/jour/article/view/3039</self-uri><abstract><sec><title>Цель</title><p>Цель. Изучение спектра, частоты и факторов риска коморбидных инфекций при ревматических заболеваниях (РЗ) у стационарного контингента больных, госпитализированных в ФГБНУ НИИР им. В.А. Насоновой в течение 1 года.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В исследование включено 245 больных с РЗ: 122 больных страдали ревматоидным артритом, 62 – системной красной волчанкой, 61 – системной склеродермией. Все больные были опрошены врачом-исследователем с заполнением соответствующей анкеты. При необходимости дополнительную информацию получали при анализе медицинской документации.</p></sec><sec><title>Результаты</title><p>Результаты. В спектре инфекций у пациентов с РЗ преобладали инфекции дыхательных путей и лор-органов. Частота серьезных инфекций (СИ) на протяжении РЗ в изучаемой когорте составила 23,7–38,1%. Влияние на частоту определенных инфекций, в т. ч. и СИ, оказывают длительность и вариант течения РЗ, коморбидные заболевания, проводимая иммуносупрессивная терапия.</p></sec><sec><title>Выводы</title><p>Выводы: полученные данные свидетельствуют о значимости инфекций в ревматологии. Высокий процент обострения РЗ на фоне инфекции, преобладание инфекций дыхательных путей, в т. ч. СИ, диктуют необходимость проведения вакцинопрофилак-тики на ранних стадиях РЗ.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. Study of spectrum, frequency and risk factors of comorbid infections in rheumatic diseases (RD) in the stationary contingent of patients hospitalized in the FSBI RIR named after V.A. Nasonova within 1 year.</p></sec><sec><title>Patients and methods</title><p>Patients and methods. The study included 245 patients with RD: 122 patients suffered from rheumatoid arthritis, 62 - systemic lupus erythematosus, 61 - systemic scleroderma. All patients were interviewed by a doctor-researcher and filled in a questionnaire. If necessary, additional information was obtained during the analysis of medical records.</p></sec><sec><title>Results</title><p>Results. In the spectrum of infections in patients with RD, respiratory tract and ENT infections prevailed. The frequency of serious infections (SI) during RD in the studied cohort was 23.7–38.1%. The frequency of certain infections, including SI, is influenced by the duration and variant of RD, comorbid diseases and immunosuppressive therapy.</p></sec><sec><title>Conclusions</title><p>Conclusions: the data obtained indicate the importance of infections in rheumatology. A high percentage of RD exacerbation against the background of infection, the prevalence of respiratory tract infections, including SI, dictate the need for vaccine prophylaxis at the early stages of RD.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>инфекции</kwd><kwd>ревматоидный артрит</kwd><kwd>системная красная волчанка</kwd><kwd>системная склеродермия</kwd><kwd>пневмонии</kwd></kwd-group><kwd-group xml:lang="en"><kwd>infections</kwd><kwd>rheumatoid arthritis</kwd><kwd>systemic lupus erythematosus</kwd><kwd>systemic scleroderma</kwd><kwd>pneumonia</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Edwards C.J., Lian T.Y., Badsha H., et al. Hospitalization of individuals with systemic lupus erythematosus: characteristics and predictors of outcome. Lupus. 2003;12(9):672-6. https://doi.org/10.1191/0961203303lu452oa.</mixed-citation><mixed-citation xml:lang="en">Edwards C.J., Lian T.Y., Badsha H., et al. Hospitalization of individuals with systemic lupus erythematosus: characteristics and predictors of outcome. Lupus. 2003;12(9):672-6. https://doi.org/10.1191/0961203303lu452oa.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Aletaha D., Neogi T., Silman A.J., et al. 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Ann Rheum Dis.2010;69(9):1580-8.DOI: 10.1136/ard.2010.138461.</mixed-citation><mixed-citation xml:lang="en">Aletaha D., Neogi T., Silman A.J., et al. 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Ann Rheum Dis.2010;69(9):1580-8.DOI: 10.1136/ard.2010.138461.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Petri M., Orbai A.M., Alarcón G.S., et al. Derivation and validation of the Systemic Lupus Interna tional Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum. 2012;64(8):2677-86. doi: 10.1002/art.34473.</mixed-citation><mixed-citation xml:lang="en">Petri M., Orbai A.M., Alarcón G.S., et al. Derivation and validation of the Systemic Lupus Interna tional Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum. 2012;64(8):2677-86. doi: 10.1002/art.34473.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">van den Hoogen F., Khanna D., Fransen J., et al. 2013 classification criteria for systemic sclerosis: an American College of Rheumatology/European League against Rheumatism collaborative initiative. Arthritis Rheum.2013;65(11):2737-47. doi: 10.1002/art.38098.</mixed-citation><mixed-citation xml:lang="en">van den Hoogen F., Khanna D., Fransen J., et al. 2013 classification criteria for systemic sclerosis: an American College of Rheumatology/European League against Rheumatism collaborative initiative. Arthritis Rheum.2013;65(11):2737-47. doi: 10.1002/art.38098.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Российские клинические рекомендации. Ревматология. Под ред. Е.Л. Насонова. М.: ГЭОТАР-Медиа, 2017:142-143. [Russian clinical recommendations. Rheumatology. Edited by E.L. Nasonova. M.: GEOTAR-Media, 2017:142-143.] (In Russ.)</mixed-citation><mixed-citation xml:lang="en">Российские клинические рекомендации. Ревматология. Под ред. Е.Л. Насонова. М.: ГЭОТАР-Медиа, 2017:142-143. [Russian clinical recommendations. Rheumatology. Edited by E.L. Nasonova. M.: GEOTAR-Media, 2017:142-143.] (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Насонова ВА. Системная красная волчанка. М., 1972. [Nasonova VA. Systemic lupus erythematosus. М., 1972.] (In Russ.)</mixed-citation><mixed-citation xml:lang="en">Насонова ВА. Системная красная волчанка. М., 1972. [Nasonova VA. Systemic lupus erythematosus. М., 1972.] (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Zink A., Manger B., Kaufmann J., et al. Evaluation of the RABBIT Risk Score for serious infections. Ann Rheum Dis. 2014 Sep;73(9):1673-6. doi: 10.1136/annrheumdis-2013-203341.</mixed-citation><mixed-citation xml:lang="en">Zink A., Manger B., Kaufmann J., et al. Evaluation of the RABBIT Risk Score for serious infections. Ann Rheum Dis. 2014 Sep;73(9):1673-6. doi: 10.1136/annrheumdis-2013-203341.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Crowson C.S., Hoganson D.D., Fitz-Gibbon P.D., Matteson E.L. Development and validation of a risk score for serious infection in patients with rheumatoid arthritis. Arthritis Rheum. 2012 Sep;64(9):2847-55. doi: 10.1002/art.34530.</mixed-citation><mixed-citation xml:lang="en">Crowson C.S., Hoganson D.D., Fitz-Gibbon P.D., Matteson E.L. Development and validation of a risk score for serious infection in patients with rheumatoid arthritis. Arthritis Rheum. 2012 Sep;64(9):2847-55. doi: 10.1002/art.34530.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Chen D., Xie J., Chen H., et al. Infection in Southern Chinese Patients with Systemic Lupus Erythematosus: Spectrum, Drug Resistance, Outcomes, and Risk Factors. J Rheumatol. 2016 Sep;43(9):1650-6. doi: 10.3899/jrheum.151523.</mixed-citation><mixed-citation xml:lang="en">Chen D., Xie J., Chen H., et al. Infection in Southern Chinese Patients with Systemic Lupus Erythematosus: Spectrum, Drug Resistance, Outcomes, and Risk Factors. J Rheumatol. 2016 Sep;43(9):1650-6. doi: 10.3899/jrheum.151523.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Feldman C.H., Hiraki L.T., Winkelmayer W.C., et al. Serious infections among adult Medicaid beneficiaries with systemic lupus erythematosus and lupus nephritis. Arthritis Rheumatol. 2015 Jun;67(6):1577-85. doi: 10.1002/art.39070.</mixed-citation><mixed-citation xml:lang="en">Feldman C.H., Hiraki L.T., Winkelmayer W.C., et al. Serious infections among adult Medicaid beneficiaries with systemic lupus erythematosus and lupus nephritis. Arthritis Rheumatol. 2015 Jun;67(6):1577-85. doi: 10.1002/art.39070.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Rúa-Figueroa Í., López-Longo J., GalindoIzquierdo M., et al., Incidence, associated factors and clinical impact of severe infections in a large, multicentric cohort of patients with systemic lupus erythematosus. Semin Arthritis Rheum. 2017 Aug;47(1):38-45. doi: 10.1016/j.semarthrit.2017.01.010.</mixed-citation><mixed-citation xml:lang="en">Rúa-Figueroa Í., López-Longo J., GalindoIzquierdo M., et al., Incidence, associated factors and clinical impact of severe infections in a large, multicentric cohort of patients with systemic lupus erythematosus. Semin Arthritis Rheum. 2017 Aug;47(1):38-45. doi: 10.1016/j.semarthrit.2017.01.010.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Smitten A.L., Choi H.K., Hochberg M.C., et al. The risk of hospitalized infection in patients with rheumatoid arthritis. J Rheumatol. 2008;35(3):387–93.</mixed-citation><mixed-citation xml:lang="en">Smitten A.L., Choi H.K., Hochberg M.C., et al. The risk of hospitalized infection in patients with rheumatoid arthritis. J Rheumatol. 2008;35(3):387–93.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Doran M.F., Crowson C.S., Pond G.R., et al. Frequency of infection in patients with rheumatoid arthritis compared with controls: a population-based study. Arthritis Rheum. 2002 Sep;46(9):2287-93.</mixed-citation><mixed-citation xml:lang="en">Doran M.F., Crowson C.S., Pond G.R., et al. Frequency of infection in patients with rheumatoid arthritis compared with controls: a population-based study. Arthritis Rheum. 2002 Sep;46(9):2287-93.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Teh C.L., Wan S.A., Ling G.R. Severe infections in systemic lupus erythematosus: disease pattern and predictors of infection-related mortality. Clin Rheumatol. 2018 Aug;37(8):2081-2086. doi: 10.1007/s10067-018-4102-6.</mixed-citation><mixed-citation xml:lang="en">Teh C.L., Wan S.A., Ling G.R. Severe infections in systemic lupus erythematosus: disease pattern and predictors of infection-related mortality. Clin Rheumatol. 2018 Aug;37(8):2081-2086. doi: 10.1007/s10067-018-4102-6.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Feldman C.H., Hiraki L.T., Winkelmayer W.C., et al. Serious infections among adult Medicaid beneficiaries with systemic lupus erythematosus and lupus nephritis. Arthritis Rheumatol. 2015 Jun;67(6):1577-85. doi: 10.1002/art.39070.</mixed-citation><mixed-citation xml:lang="en">Feldman C.H., Hiraki L.T., Winkelmayer W.C., et al. Serious infections among adult Medicaid beneficiaries with systemic lupus erythematosus and lupus nephritis. Arthritis Rheumatol. 2015 Jun;67(6):1577-85. doi: 10.1002/art.39070.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Luijten R.K., Cuppen B.V., Bijlsma J.W., Derksen R.H. Serious infections in systemic lupus erythematosus with a focus on pneumococcal infections. Lupus. 2014 Dec;23(14):1512-6. doi: 10.1177/0961203314543918.</mixed-citation><mixed-citation xml:lang="en">Luijten R.K., Cuppen B.V., Bijlsma J.W., Derksen R.H. Serious infections in systemic lupus erythematosus with a focus on pneumococcal infections. Lupus. 2014 Dec;23(14):1512-6. doi: 10.1177/0961203314543918.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Van Assen S., Agmon-Levin N., Elkayam O., et al. EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases. Ann Rheum Dis. 2011;70(3):414–22. DOI: http://dx.doi.org/10.1136/ard.2010.137216.</mixed-citation><mixed-citation xml:lang="en">Van Assen S., Agmon-Levin N., Elkayam O., et al. EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases. Ann Rheum Dis. 2011;70(3):414–22. DOI: http://dx.doi.org/10.1136/ard.2010.137216.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Тарасова Г.М., Белов Б.С., Буханова Д.В. и др. Изучение иммуногенности и безопасности 23-валентной полисахаридной пневмококковой вакцины у больных системной красной волчанкой. Научно-практическая ревматология. 2018;56(4):433-438. https://doi.org/10.14412/1995-4484-2018-433-438. [Tarasova G.M., Belov B.S., Bukhanova D.V., et al. Investigation of immunogenicity and safety of 23-valent polysaccharide pneumococcal vaccine in patients with systemic lupus erythematosus. Scientific and practical rheumatology [Nauchnoprakticheskaja revmatologija]. 2018; 56(4):433-438. https://doi.org/10.14412/1995-4484-2018-433-438.] (In Russ.)</mixed-citation><mixed-citation xml:lang="en">Тарасова Г.М., Белов Б.С., Буханова Д.В. и др. Изучение иммуногенности и безопасности 23-валентной полисахаридной пневмококковой вакцины у больных системной красной волчанкой. Научно-практическая ревматология. 2018;56(4):433-438. https://doi.org/10.14412/1995-4484-2018-433-438. [Tarasova G.M., Belov B.S., Bukhanova D.V., et al. Investigation of immunogenicity and safety of 23-valent polysaccharide pneumococcal vaccine in patients with systemic lupus erythematosus. Scientific and practical rheumatology [Nauchnoprakticheskaja revmatologija]. 2018; 56(4):433-438. https://doi.org/10.14412/1995-4484-2018-433-438.] (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Буханова Д.В., Сергеева М.С., Белов Б.С. и др. Иммуногенность и эффективность 23-валент-ной пневмококковой вакцины у больных ревматоидным артритом: результаты 5-летнего наблюдения. Современная ревматология. 2018; 12(4):85-88. https://doi.org/10.14412/1996-7012-2018-4-85-88. [Bukhanova D.V., Sergeeva M.S., Belov B.S., et al. Immunogenicity and efficacy of 23-valent pneumococcal vaccine in patients with rheumatoid arthritis: results of 5-year observation. Modern rheumatology [Sovremennaja revmatologija].2018;12(4):85-88. https://doi.org/10.14412/1996-7012-2018-4-85-88.] (In Russ.)</mixed-citation><mixed-citation xml:lang="en">Буханова Д.В., Сергеева М.С., Белов Б.С. и др. Иммуногенность и эффективность 23-валент-ной пневмококковой вакцины у больных ревматоидным артритом: результаты 5-летнего наблюдения. Современная ревматология. 2018; 12(4):85-88. https://doi.org/10.14412/1996-7012-2018-4-85-88. [Bukhanova D.V., Sergeeva M.S., Belov B.S., et al. Immunogenicity and efficacy of 23-valent pneumococcal vaccine in patients with rheumatoid arthritis: results of 5-year observation. Modern rheumatology [Sovremennaja revmatologija].2018;12(4):85-88. https://doi.org/10.14412/1996-7012-2018-4-85-88.] (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Chakravarty E.F. Incidence and Prevention of Herpes Zoster Reactivation in Patients with Autoimmune Diseases. Rheum Dis Clin North Am. 2017 Feb;43(1):111-121. doi: 10.1016/j.rdc.2016.09.010.</mixed-citation><mixed-citation xml:lang="en">Chakravarty E.F. Incidence and Prevention of Herpes Zoster Reactivation in Patients with Autoimmune Diseases. Rheum Dis Clin North Am. 2017 Feb;43(1):111-121. doi: 10.1016/j.rdc.2016.09.010.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
