medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2019-9-110-120medsovet-3044Research ArticleПрактикаPracticeБезопасность и переносимость НПВС: фокус на ацеклофенакSafety and tolerability of nsaids: focus on aceclofenacУшкаловаЕ. А.UshkalovaE. A.

д.м.н., профессор кафедры общей и клинической фармакологии Федерального государственного автономного образовательного учреждения высшего образования «Российский университет дружбы народов».

Dr. of Sci. (Med), Professor of the Department of General and Clinical Pharmacology of the Federal State Autonomous Educational Institution of Higher Education «Peoples’ Friendship University of Russia».

eushk@yandex.ruЗыряновС. К.ZyryanovS. K.

д.м.н., профессор, заведующий кафедрой общей и клинической фармакологией Федерального государственного автономного образовательного учреждения высшего образования «Российский университет дружбы народов».

Dr. of Sci. (Med), Professor, Head of the Department of General and Clinical Pharmacology of the Federal State Autonomous Educational Institution of Higher Education «Peoples’ Friendship University of Russia».

sergey.k.zyryanov@gmail.comЗатолочинаК. Э.ZalolochinaK. E.

к.м.н., ассистент кафедры общей и клинической фармакологии Федерального государственного автономного образовательного учреждения высшего образования «Российский университет дружбы народов».

Cand. of Sci. (Med), Assistant of the Department of General and Clinical Pharmacology of the Federal State Autonomous Educational Institution of Higher Education «Peoples’ Friendship University of Russia».

w00100@yandex.ruФедеральное государственное автономное образовательное учреждение высшего образования «Российский университет дружбы народов».РоссияFederal State Autonomous Educational Institution of Higher Education «Peoples’ Friendship University of Russia».Russian Federation20191206201909110120Copyright © Ушкалова Е.А., Зырянов С.К., Затолочина К.Э., 20192019Ушкалова Е.А., Зырянов С.К., Затолочина К.Э.Ushkalova E.A., Zyryanov S.K., Zalolochina K.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/3044

В статье обсуждаются основные проблемы безопасности нестероидных противовоспалительных средств (НПВС). Приводятся результаты рандомизированных клинических исследований, фармакоэпидемиологических исследований и метаанализов, предполагающие более высокую безопасность ацеклофенака по сравнению с диклофенаком и другими широко применяемыми НПВС. Особое внимание уделяется новой лекарственной форме ацеклофенака – таблеткам с модифицированным высвобождением, изготовленным по технологии Clanza, зарегистрированной под торговым наименованием Ацеклагин. Он предназначен для однократного введения в сутки, что позволяет повысить приверженность терапии.

The article discusses the main problems of safety of non-steroidal anti-inflammatory agents (NSAIDs). The results of randomized clinical studies, pharmacoepidemiological studies and meta-analyses suggesting higher safety of aceclofenac compared to diclofenac and other widely used NSAIDs are presented. Special attention is paid to the new pharmaceutical form of aceclofenac – tablets with modified release, manufactured by Clanza technology, registered under the trade name Aceclagin. It is intended for a single injection per day, which allows to increase adherence to therapy.

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The authors declare that there are no conflicts of interest present.